Clinical trials: Anxious-Depressive
Mental Disorder, Substance Use Disorders
Supported Employment in Patient Aligned Care Teams
In response to the Rehabilitation Research and Development (RR\&D) Deployment Health Research, this study addresses the delivery of an evidenced-based vocational rehabilitation, specifically Individual Placement and Support…
- Conditions
- Mental Disorder, Substance Use Disorders, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT02400736
- Testing
- Individual Placement and Support (IPS), Treatment as Usual Vocational Rehabilitation/Transitional Work (TUA-VR)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Cancer Breast, Colon Cancer
The Effect of Acceptance and Commitment Approach-Based Psychoeducation in Cancer Survivors
The study is planned to be conducted in a randomised controlled experimental design in accordance with CONSORT. The study is planned to be conducted between September 2025 and December 2026 at X Hospital with individuals who have…
- Conditions
- Cancer Breast, Colon Cancer, Cancer Survivors
- Trial name
- NCT07205965
- Testing
- Experimental Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Mild Cognitive Impairment, Depressive Symptoms
HEPPI: Efficacy of a Cognitive-Emotional Intervention for Homebound Older Adults
The main goal of this research is to assess the efficacy of a 10-week home-delivered cognitive-emotional intervention program for homebound older adults presenting Mild Cognitive Impairment (MCI) and depressive and/or anxiety…
- Conditions
- Mild Cognitive Impairment, Depressive Symptoms, Anxiety State
- Trial name
- HEPPI (NCT05499767)
- Testing
- HEPPI
- Where
- Portugal
- Volunteers
- 199 people
- Sponsor
- University of Coimbra
Postpartum Depression (PPD), Postpartum Anxiety
AI-Enabled Wearable Monitoring for Detection of Postpartum Depression and Anxiety
The goal of this observational study is to examine whether passively collected wearable data can be used to predict onset and severity of postpartum depression and anxiety symptoms. The main questions it aims to answer are: 1.
- Trial name
- NCT07866053
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Stress Disorders, Post Traumatic, Brain Injuries
Mind-Body Skills Groups for the Treatment of War Zone Stress in Military and Veteran Populations
The purpose of this study is to determine whether participation in mind-body skills groups by veterans who have experienced a stressful war-related situation and have symptoms of posttraumatic stress disorder (PTSD), will improve…
- Conditions
- Stress Disorders, Post Traumatic, Brain Injuries, Depressive Disorder, Anxiety Disorders
- Trial name
- NCT01093053
- Testing
- Mind-Body Skills Groups, Standard Treatment
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Center for Mind-Body Medicine
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression, Anxiety
The Effect of Selective Serotonin Reuptake Inhibitor (SSRI) Treatment on Affective Symptoms and Fertility Treatment Outcome in Women Undergoing in Vitro Fertilization (IVF)
Women undergoing IVF show a high prevalence of depressive and anxiety symptoms. Furthermore, stress has harmful consequences on IVF and pregnancy outcomes. An immunological cascade was suggested to be involved in the process.
- Conditions
- Depression, Anxiety, In Vitro Fertilization
- Trial name
- NCT00989053
- Testing
- escitalopram
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Same-Sex Relationships
Better Together: A Web-based Relationship Education Tool
Health disparities have been documented in same-sex partnered women, including higher rates of cardiovascular disease, Type 2 diabetes, cancers, and mental health disorders.
- Trial name
- NCT03953495
- Testing
- Better Together
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Sharon Scales Rostosky
Post-Traumatic Stress Disorder
Virtual Reality (VR) Therapy for Post-Traumatic Stress Disorder (PTSD)
It is proposed that using Virtual Reality as part of therapy will result in improvements in Post Traumatic Stress Disorder for Service Members with PTSD related to service in Iraq and/or Afghanistan.
- Trial name
- NCT00992953
- Testing
- Treatment as Usual, Virtual Reality Exposure with Stimulus Control
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Office of Naval Research (ONR)
Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute
Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration
The investigators are conducting a randomized controlled trial to assess the impact of Resiliency in Stressful Experiences (RISE) - a comprehensive trauma-based program for young men releasing from a southeastern state's prisons.
- Conditions
- Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute, Depressive Symptoms, Anxiety
- Trial name
- NCT04785677
- Testing
- Resiliency in Stressful Experiences (RISE) Program
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- Florida State University
Depression, Anxiety
The CARE (Collaborative Adolescent Running Experience) Project
This study is being completed to see if participants activity levels may have an impact as a treatment for depression, or depressive symptoms.
- Conditions
- Depression, Anxiety, Major Depressive Disorder, Bipolar Disorder
- Trial name
- CARE (NCT05837351)
- Testing
- Exercise -Running
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Michigan
Major Depressive Disorder, Generalized Anxiety Disorder
Augmenting Mental Health Support Through a Supportive Text Messaging Program
Patients seeking mental health care and those being discharged from psychiatric units frequently express psychological distress.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Mental Health Wellness 1
- Trial name
- Text4Support (NCT05411302)
- Testing
- Mental health supportive text messages
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- Vincent Agyapong
Suicidal Ideation, Depression
Population Screening Using Smartphone in Milpa Alta
The objective of this study is to make a suicide screening in the entire population of Milpa Alta (approximately 150,000 inhabitants), taking into account other outcomes such as depression, anxiety, alcohol and drugs.
- Conditions
- Suicidal Ideation, Depression, Depressive Disorder, Anxiety
- Trial name
- Smart-screen (NCT04067063)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 150,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
PTSD (Childbirth-Related), Severe Maternal Morbidity
Debriefing Consult for Psychiatric Symptoms After Severe Maternal Morbidity
The primary objective of this study is to determine if a maternal fetal medicine (MFM) debriefing consult six to eight weeks postpartum reduces self-reported post-traumatic stress, depression, and anxiety symptoms following a…
- Conditions
- PTSD (Childbirth-Related), Severe Maternal Morbidity, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07684521
- Testing
- Virtual maternal fetal medicine debriefing consult
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Cedars-Sinai Medical Center
Autistic Spectrum Disorder, Anxiety Disorders
Feasibility Study of UP-A-AST Parent Group for Adolescents With Autism and Co-occurring Anxiety/Depression
Autism spectrum disorder (ASD) is associated with high rates of psychiatric comorbidity, particularly anxiety and depressive disorders, which contribute to significant impairment for affected youth and their families.
- Conditions
- Autistic Spectrum Disorder, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT07637799
- Testing
- Unified Protocol-Adolescent Autism Parent Group (UP-A-AST)
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Sahlgrenska University Hospital
Generalized Anxiety Disorder (GAD), Major Depressive Disorder
Therapy and Tech Study
The investigators want to test if gen AI can support therapy by recruiting patients already in therapy.
- Trial name
- NCT07225192
- Testing
- Chatbot Therapy
- Volunteers
- 204 people
- Sponsor
- University of California, Irvine
Breast Feeding, Premature Birth
Meditation for NICU Moms
This project explores whether meditation increases breastmilk supply in mothers who are pumping milk for infants in the NICU. Mothers will be randomly assigned to daily meditation while pumping using an app designed for…
- Conditions
- Breast Feeding, Premature Birth, Stress, Depression, Postpartum
- Trial name
- NCT03574766
- Testing
- Meditation
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Postpartum Pain, Postpartum Depression
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Patients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.
- Conditions
- Postpartum Pain, Postpartum Depression, Opioid Consumption
- Trial name
- NCT04017442
- Testing
- Preservative Free Morphine, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anxiety Disorder, Depressive Disorder
Efficacy of the Unified Protocol for the Transdiagnostic Treatment (UP-A; Ehrenreich-May et al., 2018) for Adolescents With Moderate Emotional Symptoms in Educational Settings
The main goal is to assess the efficacy of the Unified Protocol for the Transdiagnostic Treatment (UP-A; Ehrenreich-May et al., 2018) for Adolescents with moderate emotional symptoms in educational settings The goal is to prevent…
- Conditions
- Anxiety Disorder, Depressive Disorder, Emotional Problem, Emotional Disorder
- Trial name
- PSICE (NCT05322642)
- Testing
- UPA, Active control condition (Progressive Relaxation Training)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Eduardo Fonseca Pedrero
Depression - Major Depressive Disorder, Depression Anxiety Disorder
Group-based ACT for Psychological Distress of Young People
This clinical study investigates the effectiveness of two psychological treatment formats for young people aged 16-25 with symptoms of depression, anxiety, stress, or interpersonal difficulties.
- Conditions
- Depression - Major Depressive Disorder, Depression Anxiety Disorder, Anxiety, Anxiety Depression
- Trial name
- ACT-YOUNG (NCT07617467)
- Testing
- Group-based Acceptance and Commitment Therapy, TAU
- Where
- 2 sites in Norway
- Volunteers
- 212 people
- Sponsor
- Sorlandet Hospital HF