Clinical trials: Anxious-Depressive
Depressive Disorder, Major, Anxiety Disorder
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
The study will investigate whether a nociceptin receptor antagonist will normalize neural and behavioral processes of approach/avoidance decision-making in unmedicated individuals with major depressive disorder (MDD) and anxiety…
- Trial name
- NCT05232032
- Testing
- Nociceptin Receptor Antagonist, Aversive stimuli
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cardiovascular Diseases, Coronary Artery Disease
Depressive Symptoms After Cardiac Surgery
The primary goal of this project is to develop a predictive model for clinically significant depressive symptoms (CSDS) in patients undergoing coronary artery bypass graft (CABG) surgery, using pre- and perioperative data.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Heart Diseases, Depression
- Trial name
- PCD (NCT06706323)
- Where
- 2 sites in Switzerland
- Volunteers
- 300 people
- Sponsor
- Roland von Känel
Perinatal Depression, Depression, Postpartum
Thinking Healthy Program-Technology Assisted (THP-TA)
Background The Thinking Healthy Program (THP) is an evidence based task-shifted low intensity psychosocial intervention, recommended by the World Health Organization for the treatment of perinatal depression.
- Trial name
- THP-TA (NCT05353491)
- Testing
- Technology assisted Thinking Healthy Program (THP-TA), Standard Thinking Healthy Program
- Where
- Pakistan
- Volunteers
- 980 people
- Sponsor
- Human Development Research Foundation, Pakistan
Anxiety Disorders, Alcohol Use Disorder
Monitoring Telemedicine Platform in Patients With Anxiety Symptoms and Alcohol Use Disorder
The objective of this study is to analyze the physiological patterns of two groups of patients, one control and one with anxiety disorder and alcoholic abuse disorder using sensor data from mobile devices and wearables.
- Conditions
- Anxiety Disorders, Alcohol Use Disorder, Depressive Disorder
- Trial name
- REMOTE (NCT03991650)
- Testing
- Monitoring with a device
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- humanITcare
Depressive Disorder, Anxiety Disorder
Feasibility of Process-based Therapy in a Naturalistic Setting
The main objective is to explore the feasibility of Process-based Therapy in a natural mental health care setting delivered by practitioners.
- Trial name
- PBaPP (NCT06530888)
- Testing
- Process-based Cognitive Behavioral Therapy (PBT), Routine practice (r-PT)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Goethe University
Postpartum Depression (PPD), Self-Efficacy
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the…
- Conditions
- Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient
- Trial name
- NURTURE (NCT07214597)
- Testing
- VoiceLove mobile phone application
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Bipolar Disorder
Self-compassion and Bipolar Disorder
Currently, pharmacotherapy is central in the management of bipolar disorder (BD), but does not guarantee satisfactory results for many patients.
- Trial name
- COMPASS-TB (NCT06497868)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Autism Spectrum Disorder, Depressive Disorder
Feasibility, Acceptability, and Preliminary Effectiveness of Cognitive Behavioral Therapy for Depression in Autistic Youth in Clinical Settings
The goal of this clinical trial is to learn if Cognitive Behavioral Therapy for Depression in Autistic Youth (CBT-DAY) can improve depressive symptoms and related mechanisms in autistic youth aged 11-17 years with depression…
- Conditions
- Autism Spectrum Disorder, Depressive Disorder, Anxiety Disorders
- Trial name
- CBT-DAY (NCT07755137)
- Testing
- CBT-DAY (Cognitive Behavioral Therapy for Depression in Autistic Youth), Treatment-as-Usual (TAU)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Children's Hospital Los Angeles
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
This study will evaluate whether pregnenolone is an effective treatment for adults with Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD).
- Trial name
- PREG-AUD-RO1 (NCT07734701)
- Testing
- Pregnenolone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sherwood Brown, MD, PhD
Anxiety, Depressive Symptoms
Rare Group Problem Management Plus
Participants are being asked to be in the study if they are the parent or legal guardian of a child (>1 year or <18 years old) with a rare condition.
- Conditions
- Anxiety, Depressive Symptoms, Post-traumatic Stress Disorder, Problems Psychosocial
- Trial name
- Group PM+ (NCT06548022)
- Testing
- Rare Group Problem Management Plus
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's National Research Institute
Depression - Major Depressive Disorder, Anxiety Chronic
The Effectiveness and Efficacy of an Online Cognitive Behavioral Psychotherapeutic Program
An online group cognitive behavioral psychotherapeutic program will be offered to patients with cystic fibrosis and to caregivers by the Hellenic Cystic Fibrosis Association.
- Conditions
- Depression - Major Depressive Disorder, Anxiety Chronic, Anxiety, Functional Outcome
- Trial name
- RAKITZIHCFA (NCT07255131)
- Testing
- Group A An online group cognitive behavioral psychotherapy in 13 sessions via Zoom, Group B An online group supportive psychotherapy in 13 sessions via Zoom, Group C An online group cognitive behavioral psychotherapy in 13 sessions via Zoom
- Where
- Greece
- Volunteers
- 52 people
- Sponsor
- Rakitzi, Stavroula
Depression - Major Depressive Disorder, Anxiety
Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans
This project will integrate pharmacological and psychophysiological methodology to mechanistically investigate, in humans, the role of N/OFQ in laboratory phenotypes of both disorders.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Stress
- Trial name
- NCT06786637
- Testing
- Nociceptin Receptor Antagonist (LY-2940094), DS8R Biphasic Constant Current Stimulator
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Anxiety
Intervention Targeting Depressive Symptoms and Mental Rumination
This study aims to investigate the combine effects of Behavioral Activation and Attention Training on depression, well-being and other processes involved in depression as rumination.
- Trial name
- NCT04595539
- Testing
- Behavioral Activation treatment with Attention Training Technique
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University of Liege
Diabetes (DM), Diabete Mellitus
Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups
Mental conditions and disorders (e.g. distress, depressive, anxiety, and eating disorders) are more prevalent in people with diabetes (PWD) and associated with reduced quality of life and impaired glycaemic outcomes.
- Conditions
- Diabetes (DM), Diabete Mellitus, Diabete Type 1, Diabete Type 2
- Trial name
- TwinPeaks (NCT07212075)
- Where
- 3 sites in Germany
- Volunteers
- 1,809 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Cerebral Stroke
Links Between Depression, Anxiety, Coping and Quality of Life After a Stroke
Introduction and literature review With 130 000 cases per year in France in 2010, stroke is one of the most common neurological diseases, often leaving many disabling sequelae physical and cognitive levels (currently live 500 000…
- Trial name
- COPING (NCT02778334)
- Testing
- survey
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Pancreas Adenocarcinoma
Analysis Of The Anxiety-Depressive Pattern, Quality Of Life And Assessment Of Personality in Patients With Pancreatic Ductal Adenocarcinoma (PACT24)
The aim of this study is the evaluation of psychological aspects, such as anxiety-depressive patterns, quality of life, personality and other psychopathological syndromes of patients who receive a diagnosis of pancreatic cancer…
- Trial name
- NCT04396093
- Testing
- psychological support
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Michele Reni
Psychological Distress, Quality of Life
The Effectiveness of Culturally Adapted Cognitive Behavioral Intervention Among COVID-19 Survivors
The effectiveness study for Culturally-Adapted Cognitive Behavioral Intervention (CA-CBI) will be conducted with individuals infected with and recovered from Coronavirus disease (COVID-19) to measure if this intervention is…
- Conditions
- Psychological Distress, Quality of Life, Depressive Symptoms, Anxiety
- Trial name
- NCT04949061
- Testing
- Culturally Adapted Cognitive Behavioral Intervention (CA-CBI), Enhanced Treatment as Usual (ETA-U)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Koç University
Depression, Anxiety
Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study
This is a quasi-experimental evaluation of psychoeducational course focusing on mindfulness and lifestyle changes for depression and anxiety; clients in active treatment group are compared to those in a treatment-as-usual…
- Conditions
- Depression, Anxiety, Major Depression
- Trial name
- NCT01230047
- Testing
- Psychoeducational course
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arizona State University
Post-Acute COVID-19 Syndrome, Biofeedback, Psychology
Prevention of Long Covid Syndrome
Biofeedback equipment is classified by the Food and Drug Administration (FDA) as medical device class II and this type of equipment/treatment has shown evidence regarding stress management in post-Covid-19 syndrome.
- Conditions
- Post-Acute COVID-19 Syndrome, Biofeedback, Psychology, Quality of Life, Depressive Symptoms
- Trial name
- NCT05793736
- Testing
- Biofeedback training, Treatment as usual
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- University of Cagliari
Anxiety Disorders, Depressive Disorder
Anxiety and / or Depressive Disorders in a Population of French Airline Pilot
Throughout their career, the medical abilities of airline pilots are regularly assessed. This population is exposed to occupational constraints and risks, in particular psychosocial, and could constitute a population at risk of…
- Trial name
- AEROPSY (NCT05446519)
- Testing
- Survey
- Where
- France
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice