Clinical trials: Anxious-Depressive
Depression - Major Depressive Disorder, Anxiety
Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis
This parallel three-arm, single-blind (assessor-blinded), randomized controlled trial (RCT) aims to compare the effects of ACT, CBT, and treatment-as-usual (TAU) on the severity of depressive symptoms (primary outcome), the…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Marital Conflict
- Trial name
- NCT07808021
- Testing
- Acceptance and Commitment Therapy, Cognitive Behavioral Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Major Depressive Disorder
A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptoms
The purpose of this study is to evaluate the efficacy and overall safety and tolerability of treatment with adjunctive JNJ-40411813 compared to placebo in patients with MDD with anxiety symptoms being treated with an…
- Trial name
- NCT01582815
- Testing
- JNJ-40411813
- Where
- 26 sites in Bulgaria, Hungary and 4 more
- Volunteers
- 121 people
- Sponsor
- Janssen Research & Development, LLC
Postpartum Hemorrhage, Postpartum Women
Prevalence of Psychological Disorders After Immediate Postpartum Hemorrhage
The objective of this cross-sectional study is to assess the prevalence of depression at 2 months, 6 months, and 1 year postpartum in women who had an immediate postpartum hemorrhage (immediate PPH defined as blood loss ≥ 500 mL…
- Conditions
- Postpartum Hemorrhage, Postpartum Women, Postpartum Depression, Postpartum Stress
- Trial name
- PSYCHE (NCT03120208)
- Testing
- • The Edinburgh postnatal depression scale (EPDS), validated in French, with a discrimination threshold ≥ 11., The GAD-7 with a discrimination threshold ≥10., • Spielberger's State-Trait anxiety inventory, Form Y (validated in French), with a STAI (form Y-A) discrimination threshold ≥ 46
- Where
- France
- Volunteers
- 1,298 people
- Sponsor
- University Hospital, Clermont-Ferrand
Depressive Symptoms, Anxious Symptoms
Mindfulness for Emerging Adults Experiencing Anxious and/or Depressive Symptoms
Emerging adults (EA; 18 to 29 years old) in Canada are among the age group with highest risk of developing mental health issues. Despite this, they experience especially long wait-times for mental health services.
- Trial name
- NCT03769233
- Testing
- Mindfulness-based Intervention
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- York University
Generalized Anxiety, Introspective & Anxiety-Prone Patient
Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.
In France today, it is estimated that one in every 850 people aged between 20 and 45 is a childhood cancer survivor (CCS), equivalent to around 40,000 to 50,000 people.
- Conditions
- Generalized Anxiety, Introspective & Anxiety-Prone Patient, Depression, Anxiety, Survivors of Childhood Cancer
- Trial name
- HARMONY-Tool (NCT07117058)
- Testing
- New rapid screening tool for anxiety and depressive disorders, SCARED-R-51 (Screen for Child Anxiety Related Emotional Disorders-Revised), HADS (Hospital Anxiety and Depression Scale)
- Where
- 7 sites in France
- Volunteers
- 545 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Burn Out, Stress, Psychological
Study of Positive Psychology and Effects on Well-being of Anaesthesiologists in Hong Kong
This clinical trial aims to evaluate whether positive psychology interventions via a hybrid approach will enhance well-being and resilience amongst anaesthesiologists in Hong Kong.
- Conditions
- Burn Out, Stress, Psychological, Well-Being, Psychological, Self-Compassion
- Trial name
- NCT06148454
- Testing
- App-based Positive Psychology Intervention (A&B), App-based Positive Psychology Intervention (C&D)
- Where
- Hong Kong
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hong Kong College of Anaesthesiologists
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stress (Psychology), Resilience, Psychological
High-Tech, High-Touch
Medical students often experience high levels of stress, anxiety, and poor sleep, especially during their first year and around exams.
- Conditions
- Stress (Psychology), Resilience, Psychological, Anxiety, Depressive Symptoms
- Trial name
- NCT07916818
- Testing
- Wearable ring with continuous biometric monitoring, AI health coaching application, Osteopathic manipulative treatment (OMT)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology
Adapting Mental Health Interventions for War-Affected Youth Through Employment Programs
The research will first examine data obtained from YRI participants to investigate effects of the group sessions on psychosocial functioning outcomes in youth aged 15 - 24.
- Conditions
- Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology, Social Problems/Psychology, Violence, Non-accidental
- Trial name
- NCT02561949
- Testing
- YRI, Income generating activity program
- Where
- Sierra Leone
- Volunteers
- 80 people
- Sponsor
- Boston College
Depression, Dysthymic Disorder
Rumination Focus Cognitive Behavior Therapy
1. To investigate the efficacy and acceptability of a guided internet-delivered transdiagnostic intervention targeting repetitive negative thinking for individuals with elevated levels of depression and generalized anxiety…
- Conditions
- Depression, Dysthymic Disorder, Panic Disorder, Social Phobia
- Trial name
- iRFCBT (NCT03507114)
- Testing
- Rumination-Focused CBT (RFCBT)
- Where
- Romania
- Volunteers
- 90 people
- Sponsor
- West University of Timisoara
Depressive/Anxiety Symptoms, Depressive Disorder
Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice
The goal of this clinical trial is to find out whether a smartphone app can help reduce symptoms of depression by supporting healthy lifestyle changes and encouraging self-monitoring in adults who visit their general practitioner…
- Trial name
- LIDIAS (NCT07022184)
- Testing
- Personalized Lifestyle Intervention
- Where
- 3 sites in Netherlands
- Volunteers
- 216 people
- Sponsor
- Radboud University Medical Center
Post-Traumatic Stress Disorder, Depression
Efficacy of EMDR Versus CBT for Post-Traumatic Stress Disorder in Pakistan
This randomized controlled trial compares Eye Movement Desensitization and Reprocessing (EMDR) therapy with Cognitive Behavioral Therapy (CBT) for the treatment of post-traumatic stress disorder (PTSD) in Pakistan.
- Conditions
- Post-Traumatic Stress Disorder, Depression, Anxiety
- Trial name
- NCT06435052
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR) Therapy, Cognitive Behavioral Therapy (CBT)
- Where
- 3 sites in Pakistan
- Volunteers
- 80 people
- Sponsor
- Khushal Khan Khattak Univeristy, Karak, Pakistan
Preoperative Anxiety, Psychological Stress
Effect of Lavender Aromatherapy on Preoperative Anxiety, Stress, and Depression in Orthopedic Surgery Patients
This study evaluates whether inhalation aromatherapy with lavender essential oil can reduce anxiety, stress, and depression in adult patients before orthopedic surgery in Jordan.
- Conditions
- Preoperative Anxiety, Psychological Stress, Depressive Symptoms, Orthopedic Surgery Patients
- Trial name
- LAV-ORTHO (NCT07513831)
- Testing
- Lavender Essential Oil Inhalation
- Where
- Jordan
- Volunteers
- 128 people
- Sponsor
- Al-Zaytoonah University of Jordan
Depression, Anxiety
Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study
This is a quasi-experimental evaluation of psychoeducational course focusing on mindfulness and lifestyle changes for depression and anxiety; clients in active treatment group are compared to those in a treatment-as-usual…
- Conditions
- Depression, Anxiety, Major Depression
- Trial name
- NCT01230047
- Testing
- Psychoeducational course
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arizona State University
Critical Illness
Cortisol Levels as a Measure of Accumulated Physiological Stress in ICU Patients Undergoing Mechanical Ventilation
Critical illness is a situation of severe and prolonged stress for patients with mechanical ventilation (MV). Between 40-80% of these patients present the Post-ICU syndrome, a set of physical, cognitive, psychological alterations…
- Trial name
- Corti-COG (NCT03736135)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Corporacion Parc Tauli
Depressive Symptoms, Anxiety
Evaluation of Mindfulness and Yoga in Basic Combat Training
The present study is a group randomized trial assessing the impact of mindfulness and yoga training on the health, performance, and well-being of soldiers in Basic Combat Training (BCT).
- Conditions
- Depressive Symptoms, Anxiety, Sleep, Emotion Regulation
- Trial name
- NCT05550610
- Testing
- Mindfulness Based Attention Training (MBAT) and Yoga
- Where
- United States
- Volunteers
- 1,896 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Major Depressive Disorder, Anxiety
The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
The purpose of this study is to determine whether vilazodone is more effective than citalopram for the treatment of anxious depression.
- Conditions
- Major Depressive Disorder, Anxiety, Comorbidity
- Trial name
- NCT02028026
- Testing
- Vilazodone, Citalopram
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Anxiety-depressive Patients Mild to Moderate
Anxiety-depressive Disorder in Primary Care and Cognitive-behavioral Treatment
OBJECTIVE: Evaluate the effectiveness of quality of life score, a cognitive-behavioral intervention by psychologists in the field of primary care in anxiety-depressive patients, mild to moderate, compared with usual care.
- Trial name
- PSICCAPAD (NCT01907035)
- Testing
- A cognitive-behavioral intervention, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 246 people
- Sponsor
- Basque Health Service
Major Depressive Disorder, Mood Disorder
Laughter Yoga Intervention for People With Major Depressive Disorder
The present study will adopt a non-blinded parallel-group randomized controlled trial design that involves a Laughter Yoga group (intervention) and a treatment-as-usual group (Control).
- Conditions
- Major Depressive Disorder, Mood Disorder, Depression
- Trial name
- NCT03163940
- Testing
- Laughter Yoga
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Stress Disorders, Post-Traumatic, Depressive Disorder, Major
Clinical Study of Biomarkers of Stress Resilience: Role of ELK1 and GPR56
70% of Europeans will be exposed to a potentially traumatic event (PTE). Following this experience, people are likely to develop various psychiatric disorders such as post-traumatic stress disorder (PTSD) or a major depressive…
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Disorder, Major, Anxiety Disorder
- Trial name
- GeBra-clin (NCT05488418)
- Testing
- Clinical, cognitive and biological tests
- Where
- 4 sites in France
- Volunteers
- 255 people
- Sponsor
- Assistance Publique Hopitaux De Marseille