Clinical trials: Anxious-Depressive
Anxiety Symptoms, Depressive Symptoms
Universal Preventive Resilience Intervention to Improve and Promote Mental Health for Teenagers
Adolescence is a period of many physical, mental, emotional, and social changes. It is also associated with risk behaviour conducts.
- Conditions
- Anxiety Symptoms, Depressive Symptoms, Behavioral Problem of Child, Mental Disorder in Adolescence
- Trial name
- UPRIGHT (NCT03951376)
- Testing
- UPRIGHT intervention
- Where
- 5 sites in Denmark, Iceland and 3 more
- Volunteers
- 4,460 people, healthy volunteers welcome
- Sponsor
- Biosistemak Institute for Health Systems Research
PTSD
Cognitive-behavioral Therapy for Treatment of Post-traumatic Stress Disorder and Related Problems
The purpose of this study is to evaluate the efficacy of a form of cognitive behavioral therapy (CBT) in a population of individuals with PTSD and common related problems (depression, anxiety or sleep disorders, pain…
- Trial name
- CBT-PTSD-RP (NCT03019497)
- Testing
- Specific Modules, Cognitive behavioral therapy
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Université de Montréal
Alcohol Drinking Related Problems, Alcohol Use Disorders
Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention
The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression…
- Conditions
- Alcohol Drinking Related Problems, Alcohol Use Disorders, Depressive Disorders, Mental Illness
- Trial name
- CoMiT (NCT06789250)
- Testing
- Internet-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Linkoeping University
Major Depressive Disorder, Generalized Anxiety Disorder
Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder
The primary objective is to test the hypothesis that quetiapine XR (Extended Release) monotherapy or adjunctive therapy to antidepressant is superior to placebo monotherapy or placebo adjunctive therapy to antidepressant(s) in…
- Trial name
- MDD/GAD (NCT00868374)
- Testing
- Quetiapine XR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Keming Gao
Postpartum Depression, Anxiety State
The Effect of Tele-Health Education Provided in the Postpartum Period in the Covid 19 Pandemic
In the planned study, it was aimed to examine the effect of tele-education offered in the postpartum period in the covid 19 pandemic on the levels of depression, attachment and anxiety of women.
- Trial name
- NCT04847362
- Testing
- Experimental
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Mental Health Issue, Depression, Postpartum
Mother and Baby Yoga Study - Early Postnatal Yoga and Mental Health
Investigating the influence of an early postnatal mother and baby yoga programme on maternal mental health and relationship with baby: a randomised feasibility study.
- Conditions
- Mental Health Issue, Depression, Postpartum, Anxiety
- Trial name
- MABY (NCT06056609)
- Testing
- Yoga
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Major Depressive Disorder, Persistent Depressive Disorder
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and anxiety disorders.
- Conditions
- Major Depressive Disorder, Persistent Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder
- Trial name
- TBT-RCT (NCT01947647)
- Testing
- Transdiagnostic Behavior Therapy, Behavioral Activation Therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideation, Social Behavior
Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA Survey Protocol
The objective of this study is to make a massive suicide risk and social behavior assessment in 24 pre-graduate education centers in Mexico City (approximately 30,000 students aged between 15 and 22 years), taking also into…
- Conditions
- Suicidal Ideation, Social Behavior, Depression, Depressive Disorder
- Trial name
- TEDUCA (NCT04067076)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 30,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Major Depressive Disorder, Social Anxiety Disorder
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response
Many patients with Major Depressive Disorder (MDD) and generalized Social Anxiety Disorder (gSAD) are treated with cognitive behavioral therapy (CBT) but few have meaningful improvement.
- Trial name
- NCT03175068
- Testing
- CBT, ST
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Depressive Disorder, Anxiety Disorder
Pharmacokinetics and Tolerability of Vortioxetine (Lu AA21004) in Child and Adolescent Patients With Depressive or Anxiety Disorder
The objective of the study is to evaluate the pharmacokinetics of vortioxetine and its metabolites in connection with multiple oral dosing in child and adolescent patients with a DSM-IV-TR diagnosis of Depressive or Anxiety…
- Trial name
- NCT01491035
- Testing
- Vortioxetine
- Where
- 7 sites in United States, Germany
- Volunteers
- 48 people
- Sponsor
- H. Lundbeck A/S
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without…
- Trial name
- NCT07065240
- Testing
- SPT-300
- Where
- 61 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Seaport Therapeutics
Depressive Symptoms
TreadWill, an Automated Intervention for Depressive Symptoms
TreadWill is a fully automated digital intervention that provides a multi-modal treatment for depressive symptoms. It includes: 1. Slides and interactive text-based conversations based on Cognitive Behavioral Therapy (CBT); 2.
- Trial name
- NCT04703491
- Testing
- Interactive and full-featured intervention, Feature-limited CCBT, Waitlist control
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Indian Institute of Technology Kanpur
Postpartum Depression, Postpartum Blues
Proactive, Personalized Postpartum Mental Healthcare
Mental health symptoms - especially depression and anxiety - are very common in new parents, affecting close to 20% of mothers and at least 10% of fathers.
- Conditions
- Postpartum Depression, Postpartum Blues, Postpartum Anxiety, Postpartum Mood Disorder
- Trial name
- P3MH (NCT03803189)
- Testing
- Usual care plus eToolkit
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Women's College Hospital
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer
Anxiety Disorders and Symptoms Depressive Symptoms, Risk Factors (Rejection, Bullying/Cyberbullying, Addictions, Healthy Lifestyle Habits, Exam Stress Management, Ecoanxiety, Expressed Emotion)
Selective Prevention Transdiagnostic Intervention for At-risk Adolescents With Booster Sessions. (PROCARE+ 2.0)
Emotional disorders such as anxiety and depression are significantly underdiagnosed and undertreated, even though they are some of the most prevalent mental health conditions, especially among young individuals.
- Trial name
- NCT06185049
- Testing
- PROCARE+ (Core intervention with add-on modules) and two booster sessions., PROCARE+ (Core intervention with add-on modules) and one booster session, PROCARE+ (Core intervention with add-on modules) without booster sessions.
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Jaén
Emotional Dysregulation, Anxiety
Comparing the Effectiveness of Reappraisal Strategies in Adult Participants
The goal of this clinical trial is to learn which reappraisal strategy works better to reduce sadness and anxiety in emerging adults.
- Conditions
- Emotional Dysregulation, Anxiety, Sadness, Anxiety Disorders and Symptoms
- Trial name
- NCT07008209
- Testing
- Reconstrual Strategy Training, Repurposing Strategy Training, Active Control
- Where
- Turkey (Türkiye)
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Ibn Haldun University
Depression, Suicide
Youth Depression and Suicide Research Network
The objective of this study is to build the Texas Youth Depression and Suicide Research Network to support the development of a Network Participant Registry and characterization of systems and interventions to examine statewide…
- Conditions
- Depression, Suicide, Suicidal Ideation, Suicide, Attempted
- Trial name
- YDSRN (NCT04572321)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Depressive Symptoms, Conduct Disorder
Intervening Early: Key Adolescent Outcomes
This study follows children into adolescence who were first randomized to intervention condition in infancy.
- Conditions
- Depressive Symptoms, Conduct Disorder, Anxiety Disorders
- Trial name
- SCOH-A (NCT04168684)
- Testing
- Attachment and Biobehavioral Catch-up (ABC), Developmental Education for Families (DEF)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Delaware
Anorexia Nervosa, Major Depressive Disorder
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa
This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or…
- Conditions
- Anorexia Nervosa, Major Depressive Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT02615119
- Testing
- Isoproterenol, Normal saline
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Postpartum Depression, Anxiety
Coparenting Intervention to Prevent Postpartum Depression
The goal of this pilot randomized controlled trial was to examine the feasibility and acceptability of an ehealth antenatal coparenting intervention (eACoP) in primiparous Pakistani women.
- Trial name
- NCT06305325
- Testing
- eHealth Antenatal Coparenting Intervention
- Where
- Pakistan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Brock University