Clinical trials: Aortic Aneurysm and Dissection
Turner Syndrome
Aortic Dimensions in Turner Syndrome
An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure.
- Trial name
- NCT00624949
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Aortic Dissection
Pre-hospital Management of Aortic Dissection
Background : Time between symptoms onset and treatment initiation is crucial in Acute aortic dissection (AAD). An anti-hypertensive treatment can be rapidly initiated before the arrival in Emergency Department (ED).
- Trial name
- FFDA (NCT04304443)
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Aorta Aneurysm, Aorta Dissection
Spanish Percutaneous Aortic INtervention REGISTRY (SPAIN REGISTRY)
Multicentre prospective registry including consecutive patients undergoing Percutaneous Endovascular Aneurysm Repair (PEVAR), Percutaneous Endovascular Thoracic Aneurysm Repair (PTEVAR) or Transcatheter Aortic Valve Implantation…
- Conditions
- Aorta Aneurysm, Aorta Dissection, Aorta Stenosis, Aortic Coarctation
- Trial name
- SPAIN (NCT04307888)
- Testing
- Perclose Proglide (Abbott)
- Volunteers
- 600 people
- Sponsor
- Sociedad Espanola de Angiologia y Cirugia Vascular
Aortic Aneurysm, Aortic Aneurysm and Dissection
A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta
The Goal of this Clinical Study is to evaluate the safety and effectiveness of the Rapidlink device in the repair or replacement of the supra-aortic vessels during open surgical repair of aortic disease affecting the thoracic…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm and Dissection, Aortic Diseases, Aneurysm of Aorta, Thoracic
- Trial name
- RAPID (NCT07078383)
- Testing
- Rapidlink
- Where
- 21 sites in United States, Austria and 3 more
- Volunteers
- 150 people
- Sponsor
- Vascutek Ltd.
Aorta Aneurysm, Dissection of Aorta
Pre and or Post Operative Blood Pressure Control With Clevidipine (Cleviprexm Medicines Company) in Aortic Aneurysm / Dissection
2. Purpose of the Study - 1. To determine the feasibility of Clevidipine use for rapidly achieving and maintaining individually specified patient BP target ranges in the pre and postoperative periods of aortic aneurysm and…
- Trial name
- Clevidipine (NCT01480531)
- Testing
- Clevidipine
- Where
- United States
- Sponsor
- Duke University
Acute Aortic Dissection
Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection
The morbidity rate of Stanford A type Acute Aortic Dissection（AAD） has been increasing, about 5-10/100,000* per year. Emergency surgery has been the main treatment for Acute Aortic Dissection, however perioperative mortality rate…
- Trial name
- NCT01894334
- Testing
- Ulinastatin, Tranexamic acid, Edaravone
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Aortic Dissection
Aortic Dissection Detection Risk Score Plus D-dimer in Suspected Acute Aortic Dissection
Acute aortic dissection (AD) is a deadly, difficult to diagnose disease presenting with an array of common and unspecific symptoms.
- Trial name
- ADvISED (NCT02086136)
- Where
- 6 sites in Brazil, Germany and 2 more
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Aortic Dissection, Stroke
Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic Dissection
Single-center retrospective cohort at China Medical University Hospital (Taichung, Taiwan) using fully de-identified electronic health records.
- Conditions
- Aortic Dissection, Stroke, Paraplegia, AKI - Acute Kidney Injury
- Trial name
- ATAAD-ICU (NCT07167628)
- Where
- Taiwan
- Volunteers
- 274 people
- Sponsor
- China Medical University Hospital
Morality, Lung Cancer
Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
Lung surgery, open aortic surgery, TEVAR, and EVAR are major operations that carry a higher incidence of perioperative mortality and complications compare to other surgery.
- Conditions
- Morality, Lung Cancer, Aortic Aneurysm, Aortic Dissection
- Trial name
- NCT05073991
- Testing
- Lung surgery, Open aortic surgery, TEVAR
- Where
- Thailand
- Volunteers
- 2,224 people
- Sponsor
- Mahidol University
Aortic Aneurysm, Aortic Dissection
Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement
The Freestyle® prosthesis (Medtronic plc, Dublin, Ireland) is a biological, porcine aortic root implanted in various combinations and techniques since the 1990s.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Endocarditis, Root Abscess
- Trial name
- NCT04068337
- Testing
- Aortic root replacement with Freestyle biological prosthesis with and without hemiarch replacement
- Where
- Switzerland
- Volunteers
- 278 people
- Sponsor
- Triemli Hospital
Chest Pain, Acute Coronary Syndrome
Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain
The ACUTE CT trial is designed to test whether the assessment of chest structures by high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy for patient with acute chest pain or other potential…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Pulmonary Embolism, Aortic Dissection
- Trial name
- ACUTE CT (NCT00855231)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Washington
Acute Coronary Syndrome, High-Risk Chest Pain
BREVOC Study: Exhaled VOCs for High-Risk Chest Pain in the ED
Study Objectives 1. Screening and identification of diagnostic biomarkers: To establish the exhaled volatile organic compound (VOC) profile of patients with acute high-risk chest pain and to differentiate high-risk chest pain…
- Conditions
- Acute Coronary Syndrome, High-Risk Chest Pain, Volatile Organic Compounds
- Trial name
- BREVOC (NCT07379567)
- Testing
- observational study
- Volunteers
- 6,000 people
- Sponsor
- Qilu Hospital of Shandong University
Enhancement of Aorta and Pulmonary Artery, Radiation Exposure
The Best Parameters for Imaging Agent Injection and Scanning Methods in Computed Tomography Angiography
Background: The contrast time-enhancement profiles of pulmonary artery (PA) and the aorta differ by using computed tomography (CT) angiography.
- Trial name
- NCT04832633
- Testing
- Different contrast media injection methods
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Mackay Memorial Hospital
Aortic Aneurysm and Dissection
Guo's Endovascular Aortic Arch Replacement of Aortic Dissection by WeFlow-Tribranch Endoprothesis: a Multicenter Pilot Study(GRAFT Study)
To explore the effect and prognosis of endovascular interventional therapy in high-risk patients with aortic arch dissection and aneurysm
- Trial name
- NCT05754541
- Testing
- WeFlow-Tribranch Aortic Arch Stent Graft System
- Where
- 4 sites in China
- Volunteers
- 20 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Aneurysm, Dissection
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
The purpose of this registry is to collect safety and performance data on all commercially available Terumo Aortic knitted and woven grafts, and cardiovascular patches in standard clinical practice.
- Conditions
- Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
- Trial name
- PANTHER (NCT04545502)
- Testing
- Gelsoft Plus Vascular Graft, Vascular Bypass Graft, Cardiovascular Patch
- Where
- 30 sites in United States, Belgium and 4 more
- Volunteers
- 2,000 people
- Sponsor
- Vascutek Ltd.
Long-term Renal Dysfunction
Comparison of the Effects of Open and Endovascular Aortic Aneurysm Repair on Long-term Renal Function
Compare the renal complication of endovascular and open repair of acute aortic dissection by including patient treated at NTUH in 2010~2013.
- Trial name
- NCT02220283
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Aortic Dissection, Aortic Root Aneurysm
Safety and Efficacy of the Minimally Invasive Bentall Procedure Via a Small Right Intercostal Incision in Patients With Aortic Root Lesions
This study intends to include patients who had aortic root lesions and were treated with Bentall surgery from January 2019 to July 2023 in the First Affiliated Hospital of Xi'an Jiaotong University.
- Conditions
- Aortic Dissection, Aortic Root Aneurysm, Minimally Invasive Surgical Procedures
- Trial name
- Mini-Bentall (NCT06177548)
- Testing
- Minimally invasive Bentall procedure
- Where
- China
- Volunteers
- 350 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Aortic Valve Disease
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
The ASCEND post-market clinical follow-up study is undertaken to evaluate safety and clinical performance of the On-X Ascending Aortic Prosthesis (AAP) used in surgical aortic valve replacement.
- Trial name
- ASCEND (NCT05082454)
- Testing
- Open repair
- Where
- 11 sites in United States, Germany and 3 more
- Volunteers
- 108 people
- Sponsor
- JOTEC GmbH
Ehlers-Danlos Syndrome, Vascular Type
SEDVasc (RaDiCo Cohort) (RaDiCo-SEDVasc)
The goal of this observational study is to describe the natural course of vascular Ehlers-Danlos syndrome, in particular the order of appearance of different types of complications (arterial, digestive, pulmonary and uterine).
- Trial name
- NCT05976841
- Where
- 17 sites in France
- Volunteers
- 340 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aortic Dissection
Nordic Consortium for Acute Type A Aortic Dissection-2
The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands.
- Trial name
- NORCAAD-2 (NCT06862583)
- Testing
- surgery, endovascular intervention
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska Institutet