Clinical trials: Aortic Arch Disease
Autoimmune Disease, Crohn Disease
Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases
This pilot trial studies how well fluorine F 18 clofarabine positron emission tomography (PET)/computed tomography (CT) works in imaging patients with autoimmune or inflammatory diseases.
- Conditions
- Autoimmune Disease, Crohn Disease, Inflammatory Disorder, Rheumatoid Arthritis
- Trial name
- NCT02925351
- Testing
- Computed Tomography, Fluorine F 18 Clofarabine, Positron Emission Tomography
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Giant Cell Arteritis, Takayasu's Arteritis
Reproductive Health in Men and Women With Vasculitis
The purpose of this study is to learn about reproductive health, including fertility and pregnancies, in people with vasculitis.
- Conditions
- Giant Cell Arteritis, Takayasu's Arteritis, Polyarteritis Nodosa, Wegener's Granulomatosis
- Trial name
- NCT02176070
- Where
- United States
- Volunteers
- 467 people
- Sponsor
- University of South Florida
Aortic Aneurysm, Aortic Aneurysm Abdominal
Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery
This clinical study aims to evaluate the effectiveness and safety of using NE'X Glue R-eco to seal suture lines. The adhesive will be applied to reduce the risk of suture line bleeding in cardiac or vascular repair surgeries, a…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm Abdominal, Valve Stenoses, Aortic, Valve Regurgitation, Mitral
- Trial name
- CLOSURE (NCT06918496)
- Testing
- Surgical placement of a prosthetic or biologic graft (patch), or an allograft for cardiac and (cardio)vascular repair.
- Where
- 2 sites in Belgium, Poland
- Volunteers
- 60 people
- Sponsor
- Grena Biomed Limited
Aortic Arch Aneurysm
Homemade Fenestrated Physician-modified Stent-grafts for Arch Aortic Degenerative Aneurysm
The aim was to evaluate early and medium-term outcomes of single and double fenestrated physician-modified endovascular grafts (PMEGs) for endovascular aortic arch degenerative aneursym repair.
- Trial name
- NCT04809896
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Isolated Right Aortic Arch
Management of Prenatally Diagnosed Isolated Right Aortic Arch
The existence of a right aortic arch integrates nosologically into the group of aortic vascular arch anomalies. In the majority of cases, a right aortic arch is associated with cono-truncal congenital heart diseases (CHD), such…
- Trial name
- ARCADE (NCT04029064)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Takayasu Arteritis (TAK)
Efficacy and Safety of Vunakizumab and Ivarmacitinib in the Treatment of Active Takayasu's Arteritis
This is a prospective, open-label, controlled, multiple centers, randonmized clinical trial. It compares the clinical efficacy and safety of vunakizumab ivarmacitinib and glucocorticoids in the treatment of active Takayasu's…
- Trial name
- VIVA-TAK (NCT07451665)
- Testing
- Vanakizumab, Ivarmacitinib, Prednisone
- Where
- 20 sites in China
- Volunteers
- 180 people
- Sponsor
- Chinese SLE Treatment And Research Group
Complex Aortic Aneurysms, Thoracoabdominal Aneurysms
Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices
The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with…
- Conditions
- Complex Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aneurysms, Juxtarenal Aneurysms
- Trial name
- CARPE-CMD (NCT02050113)
- Testing
- Custom Made Fenestrated or Branched Stent Graft
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Andres Schanzer
Takayasu Arteritis
Registration Study of Takayasu's Arteritis in China
Takayasu arteritis(TA) is a chronic progressive vasculitis predominantly affecting the aorta and its major branches. The demographic, clinical and prognostic features of Takayasu arteritis in China remains in uncertainties.
- Trial name
- TA-China (NCT03199183)
- Testing
- PET-CT, laboratory biomarker analysis, genetic sequencing
- Where
- China
- Volunteers
- 1,067 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Aortic Arch; Aneurysm, Dissecting
Guo's Aortic Arch Reconstruction: The First in Man Study of WeFlow-Arch Modular Embedded Branch Stent Graft System
This study is the first in man study of WeFlow-Arch Module Embedded Aorta Arch Stent Graft System
- Trial name
- NCT04764370
- Testing
- WeFlow-Ach Moduler Embedded Branch Stent Graft System
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Thoracic Aortic Dissection
Prospective Study for Aortic Arch Therapy With stENt-graft for Chimney technologY（PATENCY）
A prospective, multi-centre, objective performance criteria clinical trial to evaluate the safety and efficacy of Artery Stent Graft System manufactured by Lifetech Scientific (Shenzhen) Co., LTD.
- Trial name
- NCT03767777
- Testing
- Artery Stent Graft System
- Where
- 21 sites in China
- Volunteers
- 150 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Congenital Heart Defect
Post-market Clinical Follow-up Study With Magnetic Resonance Imaging Conditional Guide Wire
This is post-market clinical follow-up study on 25 consecutive patients in two centers to evaluate the safety and performance of magnetic resonance imaging conditional guide wire and the acceptability of identified risks in the…
- Trial name
- MRWIREPMCF (NCT02493634)
- Testing
- pressure gradient measurement, MRWire
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 25 people
- Sponsor
- Nano4Imaging GmbH
Aortic Dissection, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Improvement of Pulmonary Insufficiency After Aortic Dissection With Sivelestat Sodium
Aortic dissection (AD) is one of the most dangerous cardiovascular emergencies, with rapid onset, rapid progression, high fatality rate, and a variety of life-threatening complications.
- Trial name
- IPIADSS (NCT05343338)
- Testing
- Sivelestat sodium
- Where
- China
- Volunteers
- 168 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Brain Infarction, Transient Ischemic Attack
Aortic Arch Related Cerebral Hazard Trial (ARCH)
The ARCH is a controlled trial with a sequential design and with a prospective, randomized, open-label, blinded-endpoint (PROBE) methodology.
- Conditions
- Brain Infarction, Transient Ischemic Attack, Embolism
- Trial name
- ARCH (NCT00235248)
- Testing
- Warfarin, Clopidogrel-aspirin
- Where
- 2 sites in Australia, France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thoracic Aortic Aneurysm, Aortic Dissection
Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair
Thoracic endovascular aortic repair (TEVAR) for disease involving the aortic arch remains complex and challenging due the angulation and tortuosity of the arch and its peculiar biomechanical environment.
- Conditions
- Thoracic Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MALAN (NCT03824626)
- Testing
- TEVAR patients
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Ospedale San Donato
Takayasu Arteritis
A Study of Ustekinumab in Participants With Takayasu Arteritis (TAK)
The purpose of this study is to evaluate the efficacy of ustekinumab compared to placebo, in combination with oral glucocorticoid (GC) taper regimen, in participants with relapsing Takayasu Arteritis (TAK).
- Trial name
- NCT04882072
- Testing
- Ustekinumab, Glucorticoid Taper Regimen
- Where
- 27 sites in Japan
- Volunteers
- 14 people
- Sponsor
- Janssen Pharmaceutical K.K.
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic
Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
Prospective, nonrandomized, single-center, two-arm study to assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aortic aneurysms and aortic arch…
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic, Aortic Dissection, Thoracoabdominal
- Trial name
- NCT02323581
- Testing
- Endovascular treatment of Thoracoabdominal Aortic Aneurysm, Endovascular treatment of Aortic Arch Aneurysms
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Darren Schneider, M.D.
Aortic Arch Aneurysm, Aortic Arch Pseudoaneurysm
Triple Branched Stent Graft System for Aortic Arch Lesions
The goal of this clinical trial is to evaluate the safety and efficacy of the Triple Branched Covered Stent Graft System in treating aortic arch lesions.
- Conditions
- Aortic Arch Aneurysm, Aortic Arch Pseudoaneurysm, Aortic Arch Ulcer
- Trial name
- TRACE (NCT07067840)
- Testing
- Treated with the triple branched stent graft system
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Changhai Hospital
Congenital Heart Disease, Hypoplastic Left Heart Syndrome
Erythropoetin Neuroprotection for Neonatal Cardiac Surgery
Brain problems occur in neonatal open heart surgery with a frequency of 20-70%, seen on neurological examination, brain imaging such as magnetic resonance imaging (MRI), or long term development problems such as learning…
- Conditions
- Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Transposition of the Great Arteries, Aortic Arch Hypoplasia or Interruption
- Trial name
- NCT00513240
- Testing
- Erythropoetin, Normal saline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Baylor College of Medicine
Takayasu's Arteritis
Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis
Clinical study of anti-tumor necrosis factor therapy in patients with Takayasu arteritis. This study is single arm (anti Tumor necrosis factor therapy only) clinical trial. Enrolled patients will be 11
- Trial name
- NCT02457585
- Testing
- remicade (anti tumor necrosis factor inhibitor)
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Proximal Aortic Dissection
Safety and Efficacy of Fibrinogen Concentrate in Aortic Arch Surgery Involving Moderate Hypothermic Circulatory Arrest
Bleeding is a common complication of cardiac surgery, especially aortic arch surgery involving moderate hypothermic circulatory arrest.
- Trial name
- SEFC (NCT02542306)
- Testing
- fibrinogen concentrate
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hongjia Zhang