Clinical trials: Aortic Dissection
Aortic Aneurysm, Aortic Dissection
Cardiovascular Health Improvement Project
The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Bicuspid Aortic Valve (BAV), Heart Failure
- Trial name
- CHIP (NCT02306200)
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aortic Dissection, Aneurysm, Aortic Arch
Concave Supra-arch Branched Stent-Graft System for Treatment of Aortic Arch Diseases
There are no endoluminal stent systems available on the Chinese market for the effective treatment of aortic arch lesions (involving aortic arch aneurysms, aortic coarctation, aortic pseudoaneurysms, aortic ulcers, and intermural…
- Conditions
- Aortic Dissection, Aneurysm, Aortic Arch, Aortic Pseudoaneurysm, Aortic Ulcer, Penetrating
- Trial name
- NCT05996354
- Testing
- Concave Supra-arch Branched stent-graft system
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
AKI - Acute Kidney Injury, PAI-1 4G/5G Polymorphism
Correlation Study of PAI-1 4G/5G Polymorphism and Postoperative AKI in Patients With Aortic Dissection
To explore the association between PAI-1 4G5G polymorphism and the risk of CSA-AKI in Stanford type A dissection patients undergoing open-heart repair surgery.
- Conditions
- AKI - Acute Kidney Injury, PAI-1 4G/5G Polymorphism, Aortic Dissection
- Trial name
- NCT05490394
- Where
- China
- Volunteers
- 283 people
- Sponsor
- Xijing Hospital
Aortic Dissection
Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair
With more and more people developing hypertension and atherosclerosis, the morbidity rate of Acute Aortic Dissection（AAD） has been increasing. Emergency surgery is the main treatment for Acute Aortic Dissection.
- Trial name
- NCT02774096
- Testing
- xenon
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Dissection of Thoracic Aorta, Dissection of Thoracic Descending Aorta
European Multi-Centre Post-Market Registry on Thoracic Endovascular Arch Repair Using Castor™ and Cratos™
The Castor™ and Cratos™ Branched Aortic Stent Graft Systems are medical devices designed for the minimally invasive endovascular treatment of thoracic aortic pathologies in the descending aorta.
- Conditions
- Dissection of Thoracic Aorta, Dissection of Thoracic Descending Aorta, Aneurysm of Aorta, Thoracic, Penetrating Aortic Ulcers (PAUs)
- Trial name
- CEDAR (NCT07668687)
- Testing
- Implantation with Castor™ stent graft, Implantation with Cratos™ stent graft
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 100 people
- Sponsor
- Shanghai MicroPort Endovascular MedTech（Group）Co., Ltd
Aortic Dissection
Zenith® Dissection Clinical Trial
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.
- Trial name
- NCT01568320
- Testing
- Endovascular Treatment (Zenith)
- Where
- 24 sites in United States, Japan
- Volunteers
- 73 people
- Sponsor
- Cook Research Incorporated
Aortic Diseases
A European Study on Medical Management Versus TAG Device + Medical Management for Acute Uncomplicated Type B Dissection
The purpose of this study is to compare endoluminal stent grafting with the GORE TAG device and Best Medical Therapy (BMT) to BMT alone in the treatment of acute uncomplicated type B aortic dissections.
- Trial name
- ADSORB (NCT00742274)
- Testing
- Gore TAG Endoprosthesis, Best Medical Therapy
- Volunteers
- 61 people
- Sponsor
- W.L.Gore & Associates
Type B Aortic Dissection
Conventional TEVAR Versus FABULOUS RCT
For High-risk Type B aortic dissections, a multicenter, prospective, randomized controlled study is conducted to compare the clinical outcomes of conventional proximal endovascular repair (TEVAR) alone versus the Fabulous system…
- Trial name
- NCT06740565
- Testing
- thoracic endovascular aortic repair
- Volunteers
- 392 people
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Dissection Type B
Safety and Efficacy of TEVAR Combined With Long Bare-metal Stents in the Intervention of ATBAD
The primary objective of this study is to evaluate the safety and efficacy of the TEVAR combined with extended bare-metal stenting (distal landing zone ≥2 cm below renal arteries) in patients with acute complicated type B aortic…
- Trial name
- SAFE-COVER (NCT06892730)
- Testing
- Hybrid TEVAR combined with long bare-metal stent intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Thoracic Aortic Dissection
Thrombosomes® in Acute Thoracic Aortic Dissections
The hypothesis is that administration of Thrombosomes® (TBX®) as hemostatic support when terminating the cardiopulmonary bypass (CPB) in patients undergoing emergency surgery for acute thoracic aortic dissection (aTAD) is safe…
- Trial name
- TTAD (NCT05771831)
- Testing
- Thrombosomes®, Standard platelet concentrate
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Jakob Stensballe, MD, PhD
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Acute Kidney Injury
Association of Intraoperative Haemodynamic and Postoperative Complications in Type A Aortic Dissection Surgery
Background To determine whether venous congestion is an important predictor of postoperative kidney injury and other adverse events after type A aortic dissection (TAAD).
- Trial name
- NCT06440161
- Testing
- Primary exposures were venous congestion defined by central venous pressure (CVP) and mean arterial pressure (MAP).
- Where
- China
- Volunteers
- 543 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Aortic Dissection Type A
CT Evaluation of Intimal Flap Mobility
Type A aortic dissection is an emergency condition, defined by the appearance of an intimal flap within the ascending aorta. Urgent treatment is required, with surgical replacement of - at minima - the tubular portion of the…
- Trial name
- CT-MOBILITY (NCT03787277)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Hypofibrinogenemia
A Point-of-care Electrochemical-based Device for Rapid Detection of Fibrinogen on Type A Aortic Dissection Surgery
This study compares the results of the existing fibrinogen concentration monitoring technology to the Electrochemical-based device, a point-of-care and rapid method,using a small amount of extra blood obtained in Type A Aortic…
- Trial name
- NCT06434389
- Testing
- the Electrochemical-based device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Kidney Injury, Nitrous Oxide
Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients
The goal of this clinical trial is to determine the effectiveness of exogenous nitric oxide therapy in reducing the occurrence of acute kidney injury in patients with acute type A aortic dissection.
- Conditions
- Acute Kidney Injury, Nitrous Oxide, Acute Type A Aortic Dissection
- Trial name
- NCT06622291
- Testing
- Nitric Oxide
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Aneurysm, Aortic Dissection
Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these…
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MAC:H-TAD (NCT04005976)
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Thoracic Aortic Dissection, Thoracic Aortic Aneurysm (true Aneurysm)
Quick Yielding Modified Short-Distance Fenestration Technique for the Treatment of Complex Aortic Arch Diseases: a Multicenter Single-Arm Objective Performance Criteria Trial(QYM-Tech Study)
Background: This study investigates the safety and efficacy of a novel surgical approach combining thoracic endovascular aortic repair (TEVAR) and in situ fenestration reconstruction of supra-aortic branches using the Quick…
- Conditions
- Thoracic Aortic Dissection, Thoracic Aortic Aneurysm (true Aneurysm), Thoracic Pseudoaneurysm, Penetrating Aortic Ulcer
- Trial name
- NCT06639243
- Testing
- QYM Technique
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Thoracic Aortic Aneurysm, Aortic Dissection
Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair
Thoracic endovascular aortic repair (TEVAR) for disease involving the aortic arch remains complex and challenging due the angulation and tortuosity of the arch and its peculiar biomechanical environment.
- Conditions
- Thoracic Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MALAN (NCT03824626)
- Testing
- TEVAR patients
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Ospedale San Donato
Stanford Type A Aortic Dissection
The Role of Thyroid Function in the Development and Prognosis of Stanford Type A Aortic Dissection.
A total of 300 consecutive cardiac patients will receive preoperative thyroid function profile evaluation, including 150 patients with Standford type A aortic dissection (STAAD) and 150 normal human.For one thing, we will compare…
- Trial name
- NCT03146494
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Aortic Dissection
4D Motion of the Aorta in the Chest and Simulated Wall Stress Distribution in Relation to Aortic Events
Aortic disease is a life-threatening condition requires swift surgery or intervention. With modern techniques and vascular prostheses, still quite a few patients suffer surgery/intervention related complications such as suture…
- Trial name
- 4D MOTION-2 (NCT04958083)
- Testing
- multiphase ECG-gated contrast-enhanced CT
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust