Clinical trials: Aortic Valve Disease
Cardiomyopathy
Evaluate the Efficacy of Disopyramide Therapy in Hypertrophic Obstructive Cardiomyopathy Patients
Population study- patients with obstructive hypertrophic cardiomyopathy that are treated with disopyramide. Tow echo examination, few hours apart, that includes strain rate will be done to each patient.
- Trial name
- NCT02917395
- Testing
- echocardiography
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Transcatheter Aortic Valve Replacemen, Left Bundle Branch Block
EArly Effect of Glucocorticoid on Incidence of Persistent Left BundlE Branch Block (LBBB) Post-TAVR (EAGLE-TAVR Trial)
Transcatheter aortic valve replacement (TAVR) has become an established alternative for the treatment of severe symptomatic aortic stenosis irrespective of surgical risk.
- Trial name
- EAGLE-TAVR (NCT06762145)
- Testing
- Methylprednisolone (Corticosteroid)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiao-dong Zhuang
Transcatheter Aortic Valve Implantation (TAVI)
Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing TAVI in Europe
Non-interventional, multi-center, international registry in patients with severe aortic stenosis (sAS) undergoing transcatheter aortic valve implantation (TAVI).
- Trial name
- BENCHMARK (NCT04579445)
- Testing
- Education on tailored Quality Improvement measures
- Where
- 28 sites in Austria, Czechia and 5 more
- Volunteers
- 2,408 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Symptomatic Aortic Stenosis
First in Human Experience of the St. Jude Medical TAVI Valve and Delivery System
The purpose of this first-in-human study is to assess the technical feasibility, deployment characteristics, and safety of the 23mm SJM Transfemoral Transcatheter Heart Valve and delivery system in subjects with severe…
- Trial name
- SJM TAVI FIH (NCT01487330)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Abbott Medical Devices
Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy
Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR)
This is a multicenter, prospective, open-label, randomized, investigator-initiated trial evaluating whether angiotensin receptor blocker (ARB) therapy improves clinical outcomes in patients with severe aortic stenosis (AS) and…
- Conditions
- Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy, Severe Aortic Stenosis
- Trial name
- ARBITAR (NCT07735130)
- Testing
- Angiotensin Receptor Blocker (ARB)
- Where
- South Korea
- Volunteers
- 632 people
- Sponsor
- Seoul National University Hospital
Aortic Stenosis
Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis
The optimal timing of surgical intervention remains controversial in asymptomatic patients with very severe aortic stenosis. The investigators therefore try to compare long-term clinical outcomes of early surgery with those of…
- Trial name
- RECOVERY (NCT01161732)
- Testing
- Early surgery
- Where
- 4 sites in South Korea
- Volunteers
- 145 people
- Sponsor
- Asan Medical Center
Aortic Valve Stenosis
Pre- and Post-TAVI Patient Assessment: Advancing Outcome Precision in Aortic Valve Therapy
The aim of this study is to evaluate the combined utility of the left atrial coupling index (LACI) and left ventricular speckle tracking echocardiography (LVSTE) in improving risk stratification and outcome prediction for…
- Trial name
- NCT07179302
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Damanhour University
Mitral Valve Regurgitation, Heart Failure
Structural Heart and Valve Network PROSPECTIVE Registry
Background: Treatments for structural heart and valve disease are quickly changing. But treatment could be improved. Researchers want to gather data from people with this disease.
- Conditions
- Mitral Valve Regurgitation, Heart Failure, Heart Valve Disease, Tricuspid Valve Regurgitation
- Trial name
- NCT03928639
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Valve Replacement
Safety and Effectiveness Study of Perceval S Valve for Extended CE Mark
The primary objective of this clinical investigation is to assess the safety and effectiveness of the Perceval S valve at 12 months after implantation when used to replace a diseased or dysfunctional aortic valve or aortic valve…
- Trial name
- CAVALIER (NCT01368666)
- Testing
- Perceval S Valve Prosthesis
- Where
- 26 sites in Austria, Belgium and 6 more
- Volunteers
- 658 people
- Sponsor
- Corcym S.r.l
Obstructive Hypertrophic Cardiomyopathy
Feasibility Study of the DragonFire for Hypertrophic Obstructive Cardiomyopathy
This study is a prospective, single-center, single-group design exploratory clinical research. No control group is set, and only subjects meeting the indications of the study device are treated.
- Trial name
- NCT06368037
- Testing
- DragonFire Transcatheter Myocardial Radiofrequency Ablation System
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hangzhou Valgen Medtech Co., Ltd
Hypertrophic Cardiomyopathy, Arrhythmia
Impact of Liwen Procedure in Obstructive Hypertrophic Cardiomyopathy on Arrhythmias
The goal of this observational study is to learn about the occurrence of various arrhythmias ( tachyarrhythmia and bradyarrhythmia ) during or after Percutaneous Intramyocardial Septal Radiofrequency Ablation.
- Trial name
- NCT06031519
- Testing
- Percutaneous Intramyocardial Septal Radiofrequency Ablation for hypertrophic obstructive cardiomyopathy (Liwen Procedure)
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Xijing Hospital
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
Individualized Early Risk Assessment for Heart Diseases
Heart failure (HF) is the common end-stage of different medical conditions. It is the only growing cardiovascular disease and its prognosis remains worse than that of many malignancies.
- Trial name
- IndivuHeart (NCT02417311)
- Testing
- Skin biopsy, genotyping and disease phenotyping
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Aortic Valve Stenosis
Hemodynamic Comparison of Tissue Aortic Valves
The purpose of this study is to: 1. Assess for hemodynamic differences at rest and with exercise between three clinically available tissue aortic valves. 2.
- Trial name
- NCT01635244
- Testing
- Aortic valve replacement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Heart Disease Structural Disorder, Ventricular Tachycardia
Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia
Sudden cardiac death (SCD) due to recurrent ventricular tachycardia (VT) is an important clinical sequela in patients with structural heart disease.
- Conditions
- Heart Disease Structural Disorder, Ventricular Tachycardia, Cardiomyopathy, Dilated, Sarcoidosis
- Trial name
- CAAD-VT (NCT05524077)
- Testing
- Ablation, Anti-arrhythmic Drugs (AADs)
- Where
- 9 sites in Australia
- Volunteers
- 162 people
- Sponsor
- Western Sydney Local Health District
Aortic Valve Disease
Prospective Long-Term Outcomes of a Standardized Ross Procedure
This standardized prospective long-term outcome analysis will help reaffirm these findings via a multicenter patient cohort and describe the best practices/techniques for stabilization of the autograft and right ventricular…
- Trial name
- ROSS (NCT06352671)
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Baylor Research Institute
Aortic Insufficiency, Aortic Stenosis
Automated Phonocardiography Analysis in Adults
Background: Computer aided auscultation in the differentiation of pathologic (AHA class I) from no- or innocent murmurs (AHA class III) via artificial intelligence algorithms could be a useful tool to assist healthcare providers…
- Conditions
- Aortic Insufficiency, Aortic Stenosis, Mitral Insufficiency, Mitral Insufficiency and Aortic Stenosis
- Trial name
- NCT03600051
- Testing
- Automated Heart Murmur Detection AI
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- CSD Labs GmbH
Disparities in Treatment of Aortic Valve Stenosis, Aortic Valve Stenosis
Racial and Economic Disparities and Unmet Needs in Patients With Severe Aortic Valvular Disease
Common barriers to receiving appropriate guideline-driven care for patients with severe aortic stenosis include referral biases by primary care providers (lack of provider education), patient comorbidities (degree of fragility)…
- Trial name
- NCT04525937
- Testing
- Patient Questionnaire, Provider Questionnaire
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Minneapolis Heart Institute Foundation
Aortic Valve Disease, Conduction Disturbances
Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study
The purpose of this study is to determine the incidence and predictors of high degree or complete atrioventricular block (AVB) (paroxysmal or persistent) in patients with new-onset persistent left bundle branch block (NOP-LBBB)…
- Trial name
- MARE (NCT02153307)
- Testing
- Implantable loop recorders system Reveal ICM LINQ®,
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Aortic Valve Stenosis
Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics
Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously.
- Trial name
- NCT01118442
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Hypertrophic Cardiomyopathy
Viz HCM (ECG Assist) Utilization Workflow Pilot
This is a prospective, open-label, multi-center workflow pilot. Viz HCM will be implemented at each participating site and all conforming incoming ECG recordings within a 6-month enrollment period will be analyzed using Viz HCM.
- Trial name
- NCT06600256
- Testing
- Viz HCM ECG Review, Baseline Effectiveness Cohort
- Where
- 5 sites in United States
- Volunteers
- 217 people
- Sponsor
- Viz.ai, Inc.
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