Clinical trials: Aortic Valve Disease
Aortic Valve Stenosis, Aortic Diseases
PENG Block forTranscatheter Aortic Valve Implantation
Pericapsular nerve group (PENG block) is a new fascial block defined by Arango et al. This block aims to block the femoral nerve and the accessory obturator nerve by injecting local anesthetic between the pubic ramus and psoas…
- Trial name
- NCT05904912
- Testing
- Postoperative analgesia management, PENG-Bupivacaine, Local infiltration-Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Aortic Valve Disease, Aortic Valve Stenosis
China Valve Registry Study-1
With the aging of Chinese population, degenerative valvular disease is becoming more and more frequent, which has brought a heavy burden to our society.
- Conditions
- Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve Insufficiency, Heart Valve Diseases
- Trial name
- CHIVAS-1 (NCT02623907)
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Stenosis, Aortic Sclerosis
Risk Factors Associated With Calcification of the Aortic Valve
The purpose of this study is to determine the degree of endothelial dysfunction and inflammation in calcific aortic valve disease associated with coronary artery disease(CAD).
- Trial name
- NCT00375336
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Charles University, Czech Republic
Aortic Valve Insufficiency, Regurgitation, Aortic Valve
Aortic Valve Replacement With Trifecta(TM)
To confirm the clinical safety and effectiveness of the Trifecta valve.
- Conditions
- Aortic Valve Insufficiency, Regurgitation, Aortic Valve, Aortic Valve Incompetence, Aortic Valve Stenosis
- Trial name
- NCT00475709
- Testing
- Trifecta Aortic Heart Valve
- Where
- 18 sites in United States
- Volunteers
- 1,022 people
- Sponsor
- Abbott Medical Devices
Aortic Stenosis, Severe
Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden
The aim of the study is to evaluate the effect of antifibrotic therapy on regression of myocardial fibrosis after TAVI in patients with baseline high fibrotic burden.
- Trial name
- Reduce-MFA (NCT05230901)
- Testing
- Standard of Care, Spironolactone 25mg, Dihydralazine
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Medical Center Goettingen
Aortic Valve Disease Mixed, Transcatheter Aortic Valve Replacement
Feasibility of Valve-in-Root Transcatheter Aortic Valve Implantation in 363 Patients After Aortic Root Replacement and Repair
Biological replacement of the aortic valve in the sense of a complete root replacement is the therapy for a dilatation or aneurysm of the ascending aorta, which also involves the aortic valve.
- Trial name
- Valve in Root (NCT06697249)
- Testing
- Analysis of postoperative CT scans checking for the feasibility of transcatheter valve-in-root implantation
- Where
- Germany
- Volunteers
- 760 people
- Sponsor
- Alicja Zientara
Chest Pain, Severe Aortic Stenosis
Myocardial Flow Reserve in Severe AS Without Obstructive Coronary Artery Disease
Exertional angina is common symptom in patients with severe aortic stenosis (AS) without obstructive coronary artery disease (CAD).
- Trial name
- NCT02575768
- Testing
- Adenosine-stress cardiac magnetic resonance imaging
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Dental Caries
Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth
Study hypothesis: a new, low polymerization stress flowable composite performs no differently to a conventional, highly filled composite filling material when used as a restorative in small cavities in back teeth.
- Trial name
- NCT01369108
- Testing
- Flowable composite, Conventional composite restorative
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Solventum US LLC
Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis
Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy.
This randomized controlled trial aims to compare early postoperative outcomes between Minimally Invasive Valve Surgery (MIVS) via right thoracotomy and Conventional Valve Surgery via median sternotomy in patients undergoing…
- Conditions
- Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis, Aortic Valve Insufficiency, Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)
- Trial name
- NCT07251660
- Testing
- Minimally Invasive Valve Surgery, Conventional Valve Surgery
- Volunteers
- 32 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Non-ischemic Cardiomyopathy, DCM - Dilated Cardiomyopathy
DZHK TORCH-Plus is a Registry for Patients With Cardiomyopathies and Serves as Source for Cardiovascular Research Studies
The DZHK TranslatiOnal Registry for CardiomyopatHies (DZHK TORCH) represents a unique resource of clinical data and high quality biological samples to enable innovative clinical and molecular studies on cardiomyopathies (CMP).
- Conditions
- Non-ischemic Cardiomyopathy, DCM - Dilated Cardiomyopathy, HCM - Hypertrophic Cardiomyopathy, HOCM - Hypertrophic Obstructive Cardiomyopathy
- Trial name
- TORCH-Plus (NCT04265040)
- Where
- Germany
- Volunteers
- 2,040 people
- Sponsor
- University Hospital Heidelberg
Aortic Valve Stenosis, Arrhythmia
Electrophysiological Outcomes After Transcatheter Aortic Valve Replacement
The TAVR-ELECTRO Registry (Electrophysiological Outcomes After Transcatheter Aortic Valve Replacement) is a single-center, observational cohort study designed to systematically evaluate the occurrence, temporal evolution, and…
- Trial name
- TAVR-ELECTRO (NCT07390513)
- Testing
- TAVR Aspirin and clopidogrel
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Williams Syndrome, Anxiety
Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome
Patients with Williams-Beuren syndrome are eight times more likely to suffer from anxiety compared to the general population. Few therapeutic solutions are proposed to these patients.
- Trial name
- WILL-COPE (NCT03827525)
- Testing
- Cognitive and Behavioral Therapy
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Valve Stenoses, Aortic
Secondary Access - FEmoral or Radial in Transcatheter Aortic Valve Implantation?
Transcatheter aortic valve implantation (TAVI) is a well-known safe and effective treatment for anatomically suitable patients with severe aortic stenosis (AS).
- Trial name
- SAFER-TAVI (NCT06284837)
- Testing
- Access site
- Where
- 3 sites in Australia
- Volunteers
- 542 people
- Sponsor
- The Alfred
Hypertrophic Obstructive Cardiomyopathy
Transapical Beating-heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy
The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy.
- Trial name
- NCT05332691
- Testing
- Transapical beating-heart septal myectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiang Wei
Aortic Valve Disease Mixed
Safety and Efficacy of Post-marketing Transcatheter Aortic Valves in "Real World" Chinese Patients
The purpose of this prospective multi-center, observational registry in China is to collect clinical baseline, procedural, and follow-up data of all patients treated with TAVR in China and to evaluate short-, mid-, and long-term…
- Trial name
- NCT06257043
- Testing
- Transcatheter aortic valve replacement
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xijing Hospital
Aortic Stenosis
SecOnd-generation seLf-expandable Versus Balloon-expandable Valves and gEneral Versus Local Anesthesia in TAVI
Aim of the study is to demonstrate equivalence of second-generation self-expandable valves (CoreValve Evolut R) in comparison to second-generation balloon-expandable valves (Edwards Sapien 3) and of local anesthesia with…
- Trial name
- SOLVE-TAVI (NCT02737150)
- Testing
- CoreValve Evolut R, Edwards Sapien 3, Local anesthesia with conscious sedation
- Where
- Germany
- Volunteers
- 444 people
- Sponsor
- Helios Health Institute GmbH
Native and Valve in Valve Aortic Valve Failure
Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation
Background: TAVR is a common therapy for people with heart problems. It stands for transcatheter aortic valve replacement, TAVR can be a better option than surgery. But it isn t safe for everyone.
- Trial name
- BASILICA (NCT03381989)
- Testing
- ASHI_INTECC Astato XS 20 0.014 guidewire
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Stenosis
Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure
The primary purpose of this study is to observe reduced access site complications in patients with heavily calcified common femoral arteries requiring Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- NCT07205068
- Testing
- Shockwave M5 IVL Catheter, Modified Seldinger Technique
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Valve Disease, Aortic
ArcFlex Sheath in TAVR Trial
TAVR is a crucial treatment method for aortic valve diseases. The requirements for the device to cross the aortic arch and for the bioprosthetic valve to be coaxial are quite high, and they are key steps for the success of the…
- Trial name
- Arc-FIT (NCT07320274)
- Testing
- ArcFlex Sheath, ordinary sheath
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University
Aortic Stenosis
Anatomical Determinants and Outcomes of Small Annulus Patients Undergoing TAVR in Different ASIAN Ethnicity
Transcatheter aortic valve implantation (TAVI) presents unique challenges for Asian patients compared to Caucasians, largely due to the prevalence of small aortic annulus (SAA) defined based on Caucasians' data (430 mm²)…
- Trial name
- NCT07240025
- Where
- Hong Kong
- Volunteers
- 31 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
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