Clinical trials: Apathy, open to volunteers
Effort Based Decision Making, Prosocial Behavior
Effort and Antidepressant Study Test
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task…
- Conditions
- Effort Based Decision Making, Prosocial Behavior, Apathy
- Trial name
- EAST (NCT06696482)
- Testing
- Escitalopram 10mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Volunteers, Motivation
Neural Bases of Motivation
Effort-based decisions are essential in daily life but strongly impaired in apathy across various brain disorders. Now, significant research to unveil the neural causes of apathy is needed.
- Conditions
- Healthy Volunteers, Motivation, Action
- Trial name
- MOTIVACTION (NCT07251816)
- Testing
- Cortico-cortical paired-associative stimulation (ccPAS), Bifocal transcranial alternating current stimulation (tACS), Combining transcranial temporal interference stimulation (tTIS) and oscillatory TMS
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Apathy
Multidimensional Apathy in Psychiatric Pathologies.
Apathy is defined by quantitative decrease in goal-directed activity in comparison to the person's previous level of functioning.
- Trial name
- AmSeD (NCT04757220)
- Testing
- Cognitive tasks with EEG recording
- Where
- France
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Apathy, Bipolar Disorder
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
The goal of this clinical trial is to identify reliable markers of apathy in elderly subjects with bipolar disorder, age between 70 and 85 years, in order to accurately identify subjects at high risk of progressing to dementia by…
- Trial name
- ANACONDA (NCT06914284)
- Testing
- Actigraphy and MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Apathy
Study of the Effects of Atomoxetine on Motivation
This study investigates how increasing noradrenaline levels with atomoxetine affects motivation and information processing relevant to apathy.
- Trial name
- STEAM (NCT07771595)
- Testing
- Atomoxetine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Huntington Disease
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
The goal of this observational study is to learn about the usefulness of a test of social functioning in persons with Huntington disease.
- Trial name
- NCT07253038
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane