Clinical trials: Aphasia, Rehabilitation
Stroke, Aphasia
Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia
Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke.
- Trial name
- MOTOLANG-AVC (NCT05776368)
- Testing
- Syntactic comprehension battery (BCS), Montreal Cognitive Assessment (MOCA), Purdue Pegboard Test
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aphasia, Apraxia of Speech
MIRAA - Implementation of Intensive Rehabilitation of Aphasia and/or Apraxia of Speech in Swedish Healthcare
Positive outcomes have been shown following intensive treatment of speech and/or language impairment post stroke, but how to design intensive treatment programs to achieve optimal recovery and neuroplasticity changes needs to be…
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- MIRAA (NCT04957225)
- Testing
- MIRAA (Multimodal Intensive Rehabilitation of Aphasia and Apraxia of speech)
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Aphasia, Language Disorders
Word-Retrieval Treatment for Aphasia: Semantic Feature Analysis
The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools…
- Conditions
- Aphasia, Language Disorders, Speech Disorders
- Trial name
- NCT00125242
- Testing
- Semantic Feature Analysis (SFA)Training
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Aphasia, Gestures
Effects of Gesture Plus Verbal Treatment (GVT) in Cantonese Speakers With Aphasia
This research aims to explore the relative efficacy of Verbal-only and GVT on naming difficulty in Cantonese-speaking people with aphasia (PWA).
- Trial name
- NCT07455162
- Testing
- Verbal treatment, Gesture plus verbal treatment
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Hong Kong University
Aphasia
Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling
The purpose of this investigation is to implement a computational model that can predict and optimize training and cross-language generalization patterns for bilingual persons with aphasia (BPA).
- Trial name
- PROCoM (NCT02916524)
- Testing
- Semantic Feature Analysis (SFA)
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Boston University Charles River Campus
Aphasia, Broca's Aphasia
Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia…
- Trial name
- STARS (NCT07688551)
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of South Carolina
Stroke, Broca's Aphasia
Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia.
The primary objective of this feasibility study is to evaluate the safety and effectiveness of targeted sub-threshold epidural cortical stimulation delivered concurrent with speech-language rehabilitation activities to enhance…
- Trial name
- NCT00170703
- Testing
- Cortical Electrical Stimulation
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Northstar Neuroscience
Aphasia
Study of Modified Constraint-Induced Aphasia Therapy Schedule to Treat Patients Following Sub-acute Stroke
The purpose of this study is to assess the feasibility of modified Constraint-Induced Aphasia Therapy (CIAT) in the early sub-acute stage and to examine the efficacy of modified CIAT versus standard treatment with the same…
- Trial name
- MCIAT (NCT01625676)
- Testing
- Investigate efficacy of modified ciat schedule, examine the efficacy of standard treatment versus modified ciat schedule
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- NRZ Magdeburg Median Kliniken GmbH & Co
Ischemic or Hemorrhagic Stroke
Impact of Art Therapy on Brain Connectivity in Recent Post-Stroke Aphasia
A stroke located in the left parieto-temporal junction is associated, in aphasic right-handed patients, with a poor prognosis for language recovery.
- Trial name
- ART-CONNECT (NCT03820843)
- Testing
- Art therapy and standard orthophonic rehabilitation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke-induced Aphasia
Overcoming Learned Non-Use in Chronic Aphasia
In this study the investigators are examining the effectiveness of intensive speech therapy in chronic moderate-to-severe stroke-induced aphasia under two conditions - responses "constrained" or unconstrained to speech.
- Trial name
- NCT02012374
- Testing
- Intensive Language Action Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Primary Progressive Aphasia
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
This project aims to measure the effect of a semantic rehabilitation protocol for patients with primary progressive semantic aphasia and using the SCED methodology.
- Trial name
- SCED-APPvs (NCT04957537)
- Testing
- semantic therapy and semantic re-education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Aphasia Non Fluent, Stroke
Effectiveness of TDCS Over Broca's Area in Verb Naming: a Randomized, Double-Blind, Crossover Study
This clinical trial investigated whether transcranial direct current stimulation (tDCS) over Broca's area (F5) could improve verb naming abilities in adults with aphasia.
- Trial name
- NCT06776978
- Testing
- Active treatment
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Stroke, Acute, Expressive Aphasia
Music After Stroke To Enhance Rehabilitation
Music that is familiar and preferred by patients has been shown to heighten neuroplasticity and can mitigate these disabilities.
- Conditions
- Stroke, Acute, Expressive Aphasia, Movement, Abnormal, Depressive Disorder
- Trial name
- MASTER (NCT04441515)
- Testing
- Ipod with music, ipod with books to listen, ipod only with usual care
- Volunteers
- 12 people
- Sponsor
- Pace University
Aphasia Non Fluent, Stroke
Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia
SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that…
- Trial name
- SEMO (NCT04433351)
- Testing
- Enriched rehabilitation, Simple rehabilitation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Grenoble
Aphasia, Acquired
Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke
Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment.
- Trial name
- ORACLE (NCT03287544)
- Testing
- Combined rehabilitation, Linguistic rehabilitation
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Toulouse
Anomic Aphasia
Virtual Reality Training for Aphasia Rehabilitation
Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language.
- Trial name
- Aphasia360 (NCT05793879)
- Testing
- Video 360, Standard videos
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Stroke
Cerebellar Stimulation for Aphasia Rehabilitation
The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in…
- Trial name
- CeSAR (NCT05093673)
- Testing
- Cathodal Cerebellar tDCS, Semantic Feature Analysis (SFA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Aphasia, Acquired
Effects of rTMS on Brain Activation in Aphasia
This study will investigate the use of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation method, to improve word-finding abilities in Veterans and non-Veterans with chronic language problems…
- Trial name
- NCT03292471
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Chronic Aphasia
Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study
This Phase II study aims to ascertain the effectiveness of HD-tDCS for adjunctive treatment of anomia in chronic aphasia post stroke.
- Trial name
- NCT02540109
- Testing
- HD-tDCS (Soterix Medical, Active)
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Soterix Medical
Aphasia, Stroke
Intention Treatment for Anomia
Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia).
- Trial name
- NCT04267198
- Testing
- Intention Treatment for Anomia
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development