Clinical trials: Aphasia, open to volunteers
Stroke and Aphasia
The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers
The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their…
- Trial name
- NCT02328573
- Testing
- Communal singing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Aphasia, Stroke
Effects of Recursive Self-feedback on Speech Production in Aphasia
The goal of this clinical trial is to test the effects of recursive self-feedback procedures on spontaneous speech production in stroke survivors with impaired speech production (aphasia).
- Trial name
- NCT06323629
- Testing
- Adaptive recursive self-feedback procedure, Non-adaptive recursive self-feedback procedure
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of South Florida
Alzheimer Disease
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease.
- Trial name
- ADVISe (NCT04576793)
- Testing
- 11C-ER176, 18F-MK6240, 18F-Florbetaben
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Aphasia, Acquired, Stroke
Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of…
- Conditions
- Aphasia, Acquired, Stroke, Healthy Aging
- Trial name
- sentence (NCT06405594)
- Testing
- Language Condition
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Aphasia, Language
Neuroplasticity Biomarkers in Aphasia
Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased…
- Conditions
- Aphasia, Language, Stroke
- Trial name
- NCT06471127
- Testing
- Pseudoword learning paradigm task
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Primary Progressive Aphasia, Dementia
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA…
- Conditions
- Primary Progressive Aphasia, Dementia, Dementia, Frontotemporal, Alzheimer Disease
- Trial name
- NCT05741853
- Testing
- Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT)
- Where
- 3 sites in United States, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stephanie Grasso
Aphasia
Criterion-learning Naming Treatment For Addressing Comprehension Deficits in Aphasia
Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today.
- Trial name
- NCT07179458
- Testing
- Criterion-learning practice
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Albert Einstein Healthcare Network
Primary Progressive Aphasia
Enhancing Language Function in Primary Progressive Aphasia
This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA).
- Trial name
- PPA (NCT04920318)
- Testing
- tDCS + language therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Aphasia, Stroke
Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life.
- Trial name
- NCT05653440
- Testing
- Accuracy-maximized condition, Effort-maximized condition, Effort-accuracy balanced condition
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Aphasia
Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia
The goal of this clinical trial is to learn whether healthy volunteers are more successful at understanding people with aphasia if they have first viewed an aphasia identification (ID) card.
- Trial name
- PAUSE (NCT06990997)
- Testing
- Aphasia identification (ID) card
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Aphasia, Stroke
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.
- Conditions
- Aphasia, Stroke, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- TMS (NCT06842745)
- Testing
- Transcranial Magnetic Stimulation (TMS), Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Non-fluent Aphasia
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Sequentially applying Melodic Intonation Therapy (MIT) during the subacute phase, followed by Constraint-Induced Aphasia Therapy (CIAT) during the chronic phase
- Trial name
- CIPAN (NCT07759375)
- Testing
- CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT
- Volunteers
- 48 people
- Sponsor
- Universidad de Granada
Primary Progressive Aphasia, Semantic Dementia
Primary Progressive Aphasia Multicomponent Language Treatment Study
The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language.
- Conditions
- Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia
- Trial name
- NCT06649084
- Testing
- Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Texas at Austin
Aphasia, Aphasia Following Cerebral Infarction
Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)
The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired…
- Conditions
- Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired, Aphasia, Rehabilitation
- Trial name
- NCT07036406
- Testing
- Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Teachers College, Columbia University
Aphasia, Apraxia of Speech
taVNS for Speech and Language Recovery in Aphasia
The goal of this research study is to evaluate a novel approach to improving speech recovery in those with acquired apraxia of speech.
- Trial name
- NCT07563387
- Testing
- taVNS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Stroke, Aphasia
Language Processing and TMS
This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
- Conditions
- Stroke, Aphasia, Language
- Trial name
- NCT05425615
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia
EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option.
- Conditions
- Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- NCT07496645
- Testing
- Transcranial Direct Current Stimulation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Stroke, Aphasia
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute…
- Conditions
- Stroke, Aphasia, Aphasia Following Cerebral Infarction
- Trial name
- NCT06968663
- Testing
- Transcranial Magnetic Stimulation (TMS), Modified Constraint Induced Language Therapy (mCILT)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Aphasia, Development, Human
Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective
The goal of this observational study is to investigate cognitive functioning profiles in adults with neurologically recognized aphasic syndromes and general population.
- Conditions
- Aphasia, Development, Human, Neuropathology
- Trial name
- NCT06365658
- Testing
- Psychological assessment
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Bartosz M. Radtke