Clinical trials: Aphasia
Post-stroke Aphasia
Neurostimulation for the Treatment of Post-Stroke Aphasia
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.
- Trial name
- NCT05194566
- Testing
- tACS
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- QVITI S.A.
Transcranial Alternating Current Stimulation, Post-stroke Aphasia
High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia
To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.
- Conditions
- Transcranial Alternating Current Stimulation, Post-stroke Aphasia, Functional Magnetic Resonance Imaging
- Trial name
- NCT05502822
- Testing
- High definition transcranial alternating current stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Residual Aphasia
Impact of Transcranial Direct Current Stimulation of the Motor Cortex on Language Functions in Residual Aphasia
The present study assesses whether language functions in patients with residual post-stroke aphasia can be improved by transcranial direct current stimulation administered to the primary motor cortex in the language dominant…
- Trial name
- StimRAph (NCT01845129)
- Testing
- atDCS
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Charite University, Berlin, Germany
Broca's Aphasia
Virtual Reality Based Sensorimotor Speech Therapy
The purpose of this study is to determine whether VR based language rehabilitation scenario based on the core premises of ILAT has a beneficial effect on the linguistic performance (faster retrieval of the target lexicon and…
- Trial name
- NCT02928822
- Testing
- VR-based sensorimotor aphasia therapy, Control Group (conventional aphasia rehabilitation)
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Universitat Pompeu Fabra
Stroke
TDCS in Acute Stroke
The purpose of this study is to determine the safety of transcranial direct current stimulation in aphasia therapy in acute and post-acute stroke.
- Trial name
- TDCS-aphasia (NCT01701713)
- Testing
- DKI ED2011
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Stroke and Aphasia
The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers
The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their…
- Trial name
- NCT02328573
- Testing
- Communal singing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Aphasia, Stroke
Galantamine Treatment for Nonfluent Aphasia in Stroke Patients
Cognitive impairment after stroke is common and has a major effect on morbidity and quality of life. Acetylcholinesterase inhibitors have demonstrated benefit in vascular dementia, but efficacy in treating more circumscribed…
- Trial name
- NCT01129479
- Testing
- Galantamine
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Aphasia
Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia
This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called 'aphasia'.
- Trial name
- NCT01163461
- Testing
- speech therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
PPA, Non-fluent Aphasia
Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with…
- Conditions
- PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia
- Trial name
- NCT01818661
- Testing
- AV-1451
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Aphasia
Neural Bases of Vocal Sensorimotor Impairment in Aphasia
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control.
- Trial name
- NCT04742894
- Testing
- Visual Feedback Training
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Primary Progressive Aphasia, Alzheimer Disease
Clinical Evaluation of Florbetapir in Primary Progressive Aphasia
The purpose of this research is to better understand how dementia affects activity in different parts of the brain.
- Conditions
- Primary Progressive Aphasia, Alzheimer Disease, Dementia
- Trial name
- PPA (NCT04726527)
- Testing
- Florbetapir F 18, Positron Emission Tomography
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Chicago
Aphasia, Stroke
Brain Biomarkers of Response to Treatment for Apraxia of Speech
The study will use MRI brain imaging to identify brain changes associated in stroke patients after they receive speech-language treatment for their speech difficulties.
- Trial name
- SPT (NCT02046941)
- Testing
- Speech Production Treatment
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Aphasia, Language Disorders
Word-Retrieval Treatment for Aphasia: Semantic Feature Analysis
The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools…
- Conditions
- Aphasia, Language Disorders, Speech Disorders
- Trial name
- NCT00125242
- Testing
- Semantic Feature Analysis (SFA)Training
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Aphasia, Stroke
The Intensive Comprehensive Aphasia Program (ICAP)
The purpose of this study is to conduct a randomized clinical trial that assesses the efficacy and cost-effectiveness of an Intensive Comprehensive Aphasia Program (ICAP), specifically focusing on the variable of intensity.
- Trial name
- NCT03514186
- Testing
- Speech and Language Therapy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia
Brain Stimulation and Aphasia Treatment
The purpose of this study is to assess the changes in language processing of patients with chronic, post-stroke aphasia following the application of brain stimulation.
- Trial name
- tDCS (NCT01686373)
- Testing
- Activa Dose II Real tDCS
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of South Carolina
Aphasia, Aphasia Non Fluent
Speech Entrainment for Aphasia Recovery
After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia.
- Conditions
- Aphasia, Aphasia Non Fluent, Stroke
- Trial name
- SpARc (NCT04364854)
- Testing
- SET (Speech Entrainment Therapy) 3 weeks, SET (Speech Entrainment Therapy) 4.5 weeks, SET (Speech Entrainment Therapy) 6 weeks
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Medical University of South Carolina
Aphasia, Gestures
Effects of Gesture Plus Verbal Treatment (GVT) in Cantonese Speakers With Aphasia
This research aims to explore the relative efficacy of Verbal-only and GVT on naming difficulty in Cantonese-speaking people with aphasia (PWA).
- Trial name
- NCT07455162
- Testing
- Verbal treatment, Gesture plus verbal treatment
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Hong Kong University
Non Fluent Aphasia in Subacute Stroke
Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
- Trial name
- NCT01850836
- Testing
- repetitive transcranial magnetic stimulation
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aphasia
Improving Electronic Written Communication in Aphasia
People with aphasia have difficulty with writing and often struggle to use electronic communication that connects people to one another.
- Trial name
- T-WRITE (NCT03773419)
- Testing
- Texting Intervention (T-WRITE), HandWriting Intervention (ORLA+WTG)
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia
Voice Adaptive Tablet-Based Naming Treatment for Adults With Aphasia
Rising life expectancy is leading to a rising incidence of strokes worldwide. Approximately one third of people who had a stroke live with a communication disorder, aphasia, which is associated with the largest negative…
- Trial name
- VoiceAdapt (NCT04108364)
- Testing
- Voice adaptive training for aphasia
- Where
- 2 sites in Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta