Clinical trials: Aphasia Non Fluent
PPA, Non-fluent Aphasia
Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with…
- Conditions
- PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia
- Trial name
- NCT01818661
- Testing
- AV-1451
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Stroke, Aphasia, Non-fluent
rTMS and Multi-Modality Aphasia Therapy for Post-Stroke Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- TMAT (NCT04901156)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Non-fluent Aphasia, Glioma
High-frequency nrTMS on the Contralateral Broca Mirror Area for Glioma Patients With Early Postoperative Aphasia
The goal of this randomized clinical controlled trial is to determine whether the application of high frequency neuronavigated repetitive transcranial magnetic stimulation (nrTMS) on the contralateral of Broca's area can…
- Trial name
- NCT05788445
- Testing
- nrTMS treatment
- Volunteers
- 48 people
- Sponsor
- Beijing Neurosurgical Institute
Stroke, Ischemic, Aphasia Non Fluent
Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia
Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere.
- Trial name
- NCT05303649
- Testing
- Noninvasive transcranial brain stimulation: excitatory iTBS, Noninvasive transcranial brain stimulation: inhibitory cTBS, Individual speech-language therapy (SLT)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Institute of Psychiatry and Neurology, Warsaw
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Aphasia, Acquired, Aphasia
Aphasia Physical EXercise Study: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent
- Trial name
- APEX (NCT07281313)
- Testing
- High-intensity physical exercise, Low-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Berkeley
Logopenic Variant Primary Progressive Aphasia, Non-fluent Variant Primary Progressive Aphasia
TMS for the Treatment of Primary Progressive Aphasia
Primary Progressive Aphasia (PPA) is a progressive syndrome in the family of Alzheimer's disease and related disorders involving devastating language impairments caused by selective neurodegeneration of the brain's language…
- Conditions
- Logopenic Variant Primary Progressive Aphasia, Non-fluent Variant Primary Progressive Aphasia, Semantic Variant Primary Progressive Aphasia
- Trial name
- NCT04188067
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Primary Progressive Aphasia, Neurodegenerative Diseases
Home-Based Exercise in Primary Progressive Aphasia (HEPPA)
This pilot study aims to evaluate the feasibility of a novel home-based multicomponent exercise program in adults clinically diagnosed with Primary Progressive Aphasia
- Conditions
- Primary Progressive Aphasia, Neurodegenerative Diseases, Logopenic Progressive Aphasia, Semantic Dementia
- Trial name
- HEPPA (NCT06181500)
- Testing
- Home-based multicomponent exercise intervention program
- Where
- 2 sites in Canada
- Volunteers
- 13 people
- Sponsor
- Montreal Heart Institute
Expressive Aphasia, Aphasia Following Cerebral Infarction
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with aphasia to generate text on a computer screen and audible…
- Conditions
- Expressive Aphasia, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage, Aphasia Non Fluent
- Trial name
- BG2-Aphasia (NCT07791459)
- Testing
- BrainGate Neural Interface System
- Volunteers
- 5 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Apraxia of Speech, Non-fluent Aphasia
The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech
The purpose of this study is to identify and distinguish two different types of Progressive Apraxia of Speech through clinical imaging and testing.
- Conditions
- Apraxia of Speech, Non-fluent Aphasia, Primary Progressive Aphasia, Primary Progressive Nonfluent Aphasia
- Trial name
- SLD4T (NCT03313011)
- Testing
- Testing protocol for the study
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Mayo Clinic
Stroke Rehabilitation, Aphasia, Broca
Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation
The goal of this Interventional Study is to develop and test the Indian Adaptation of Melodic Intonation Therapy (MIT) for Indian patients in with post-stroke Non-Fluent Aphasia (PSNFA).
- Trial name
- NCT06323330
- Testing
- Speech rehabilitation
- Where
- 3 sites in India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Nonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia
tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
The investigators will test the feasibility of using transcranial direct current stimulation (tDCS) and speech therapy to treat participants with motor speech disorders caused by Frontotemporal Lobar Degeneration Pathology…
- Conditions
- Nonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia, Primary Progressive Non Fluent Aphasia, Progressive Supranuclear Palsy
- Trial name
- NCT04883229
- Testing
- Halo Neuroscience Neurostimulator
- Sponsor
- University of California, San Francisco
Stroke
Dextroamphetamine and tDCS to Improve the Fluency
The proposed study aims to evaluate safety and efficacy of combined dextroamphetamine (Dexedrine) and transcranial direct current stimulation (tDCS) with melodic intonation therapy (MIT) for treatment of aphasia after stroke.
- Trial name
- NCT02514044
- Testing
- Dexedrine, Active tDCS, Speech Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Stroke
Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study
" This study aims to measure changes in language ability after adding cerebrolysin to standard treatment for non-fluent aphasia patients with post-stroke language impairment.
- Trial name
- NCT06897176
- Testing
- Cerebrolyisin
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Stroke, Aphasia
Effects of rTMS Based on Neural Activation in Language Performance in Stroke Patients With Non-fluent Aphasia
The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early…
- Trial name
- NCT02591719
- Testing
- MagPro magnetic stimulator (HF rTMS), MagPro magnetic stimulator (LF rTMS)
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Bundang Hospital
Aphasia, Aphasia Non Fluent
Speech Entrainment for Aphasia Recovery
After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia.
- Conditions
- Aphasia, Aphasia Non Fluent, Stroke
- Trial name
- SpARc (NCT04364854)
- Testing
- SET (Speech Entrainment Therapy) 3 weeks, SET (Speech Entrainment Therapy) 4.5 weeks, SET (Speech Entrainment Therapy) 6 weeks
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Medical University of South Carolina
Primary Progressive Aphasia
Effects of tDCS on Apraxia of Speech in Non-Fluent Primary Progressive Aphasia
Primary progressive aphasia (PPA) is a neurodegenerative disease that affects first and foremost language abilities. There are three different variants of PPA, each a relatively distinct speech and language profile.
- Trial name
- NCT04486586
- Testing
- Active tDCS plus Speech-Language Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University