Clinical trials: Apnea+Hypopnea
Sleep Apnea, Obstructive
Evaluation of the Effect of AVE0657 on Obstructive Sleep Apnea
The primary objective of this study is to assess the activity of 4 escalating doses of AVE0657 in comparison to placebo in patients with Obstructive Sleep Apnea Hypopnea Syndrome.
- Trial name
- NCT00614250
- Testing
- AVE0657
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 38 people
- Sponsor
- Sanofi
Perennial Allergic Rhinitis, Obstructive Sleep Apnea
The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726)
This is a Phase 4 randomized, placebo-controlled, parallel-group, single-center, double-blind study to evaluate the effects of mometasone furoate nasal spray (MFNS) in subjects with Sleep-disordered Breathing (SDB) associated…
- Conditions
- Perennial Allergic Rhinitis, Obstructive Sleep Apnea, Sleep Disorder
- Trial name
- NCT00359216
- Testing
- Mometasone furoate nasal spray
- Volunteers
- 30 people
- Sponsor
- Organon and Co
Obstructive Sleep Apnea, Obstructive Sleep Apnea-hypopnea
Simultaneous Operations on the Thyroid Gland and Hyoid Suspension in Patients With Combined Thyroid Pathology and OSA
Simultaneous operations on the thyroid gland and hyoid suspension in patients with combined thyroid pathology and moderate to severe OSA.
- Conditions
- Obstructive Sleep Apnea, Obstructive Sleep Apnea-hypopnea, Obstructive Sleep Apnea-hypopnea Syndrome
- Trial name
- NCT05033626
- Testing
- Simultaneous thyroidectomy and hyoid suspension, Thyroidectomy
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Obstructive Sleep Apnea Syndrome
Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients
In this open prospective study 40 patients who received Mandibular Replacement Appliance (MRA) Therapy as treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) will be included.
- Trial name
- NCT01524510
- Testing
- CT scan, Alice PDx polygraphy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Efficacy and Compliance of the Mandibular Advancement Devices ONIRIS® vs. Custom Made Devices
To evaluate the efficacy (non-inferiority) in terms of response between patients using custom fitted mandibular advancement devices ONIRIS® and patient using laboratory custom made devices TALI, after 2 months of use.
- Trial name
- IRIS (NCT02348970)
- Testing
- ONIRIS®, TALI
- Where
- 10 sites in France
- Volunteers
- 211 people
- Sponsor
- ONIRIS
Sleep Apnea Syndrome, Polygraphy
Sleep Apnea Syndrome and Community Acquired Pneumonia
The association of sleep apnea-hypopnea syndrome (SAHS) with the infections of the lower airway has not been studied. The aspiration of secretions of the upper airway and the colonization by microorganisms is considered a main…
- Conditions
- Sleep Apnea Syndrome, Polygraphy, Community Acquired Pneumonia, Infections
- Trial name
- NEBULOSA (NCT01071421)
- Testing
- abbreviated polysomnography
- Where
- Spain
- Volunteers
- 123 people
- Sponsor
- Hospital Universitario San Juan de Alicante
Obstructive Sleep Apnea, Bariatric Surgery Candidate
Pre- and Postoperative Apnea-Hypopnea Index After Same-Day Discharge Bariatric Surgery
A recent development is same-day discharge in bariatric surgery, this seems to be safe if proper discharge criteria are used. However, yet there is no guideline for these discharge criteria, including for patients with…
- Conditions
- Obstructive Sleep Apnea, Bariatric Surgery Candidate, Same-day Discharge
- Trial name
- DAGBAR (NCT06452784)
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Rijnstate Hospital
Obstructive Sleep Apnea Syndrome
Didgeridoo Treatment to Improve Pharyngeal Compliance in Obstructive Sleep Apnea-hypopnea Syndrome in Children
The therapeutic management of Obstructive Sleep Apnoea Syndrome in children remains a debated subject, only otorhinolaryngology surgery (adenoidectomy) has been studied on a large scale.
- Trial name
- SASDICO (NCT05164211)
- Testing
- Didgeridoo
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea (OSA)
Inspire UAS High Apnea Hypopnea Index (AHI)/High Body Mass Index (BMI) Post-Approval Study
The purpose of this observational clinical study is to provide evaluation of long-term safety and effectiveness in a newly expanded patient population including patients with a higher AHI and a higher BMI.
- Trial name
- AHIBMI PAS (NCT07113288)
- Testing
- Inspire® UAS System
- Where
- 5 sites in United States
- Volunteers
- 70 people
- Sponsor
- Inspire Medical Systems, Inc.
OSA
Effects of Lemborexant as a Treatment for Moderate-to-severe OSA Patients With Low Arousal Threshold
The goal of this randomized, placebo-controlled, double-blind, crossover trial (1-week wash out period) is to compare 1 night of 5 mg Lemborexant to placebo administered before sleep in 10 moderate to severe OSA patients with low…
- Trial name
- LOSALAT (NCT05763329)
- Testing
- Lemborexant 5 MG Oral Tablet [Dayvigo] Day 1, Lemborexant 5 MG Oral Tablet [Dayvigo] Day 2
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Apnea of Prematurity, Preterm Infant
Detection of Respiratory Events Using Acoustic Monitoring in Extremely Preterm Infants
Extremely preterm infants, born before 29 weeks of pregnancy, often face breathing difficulties, also known as respiratory events, due to their undeveloped lungs and respiratory systems.
- Conditions
- Apnea of Prematurity, Preterm Infant, Periodic Breathing, Hypopnea
- Trial name
- DREAM 2 (NCT07552025)
- Testing
- Wireless acoustic sensor, Semi-structured interview, Nox T3s portable sleep monitoring device
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obstructive Sleep Apnea, Sleep Hypopnea
Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea (OSA/H) Syndrome
The primary objective of this study is to determine whether treatment with Armodafinil (CEP-10953) is more effective than placebo treatment for patients with residual excessive sleepiness associated with obstructive sleep…
- Trial name
- NCT00079677
- Testing
- Armodafinil 150 mg/day
- Volunteers
- 263 people
- Sponsor
- Cephalon
Obstructive Sleep Apnoea
Morphine in Moderate Obstructive Sleep Apnoea
The aim of this study is to investigate the effects of morphine (a drug commonly used for the treatment of moderate to severe pain, particularly following surgery) on the number of pauses in breathing in patients with moderate…
- Trial name
- MIMOSA (NCT03127800)
- Testing
- Morphine sulphate
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Sleep Apnea Hypopnea Syndrome, Physical Activity
Effect of an Aerobic Exercise Program in Patients With Moderate-severe Sleep Apnea
In this paper, it is postulated that in sedentary patients with moderate-severe sleep apnea diagnosed by a sleep test, an increase in physical activity stimulated by the use of a pedometer during a period of 6 months can reduce…
- Trial name
- SAH-2014 (NCT03997877)
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Sleep Apnea Syndromes
Effectiveness of VistaO2 FLUX Device in Screening of Sleep Apnea/Hypopnea Syndrome
The high prevalence (9% in men and 4% in women) of sleep apnea / hypopnea syndrome (SAHS) in adults is now well documented as well as its cardiovascular repercussions.
- Trial name
- VISTAO2_FLUX (NCT02357719)
- Testing
- VistaO2 FLUX device
- Where
- 2 sites in France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Obstructive Sleep Apnea-hypopnea in Multiple Sclerosis Patients
Sleep Apnea in Multiple Sclerosis Positive Airway Pressure Trial
Fatigue is highly prevalent among multiple sclerosis (MS) patients and has pervasive adverse effects on daily functioning and quality of life.
- Trial name
- SAMSPAP (NCT01746342)
- Testing
- Effective continuous positive airway pressure (CPAP)
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- McGill University
Sleep Apnea, Type 2 Diabetes
Evolution With CPAP Treatment of a Cohort of Type 2 Diabetic Patients With Apnea-hypopnea Syndrome
The main purpose of this study is to measure the evolution of hemoglobin A1c level after treatment with CPAP in a cohort of type 2 diabetes mellitus patients with poor glycemic control and associated moderate or severe…
- Trial name
- DM2-CPAP (NCT01307566)
- Testing
- Continuous Positive Airway Pressure CPAP
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital de Granollers
Sleep Disorders, Obstructive Sleep Apnea
Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression
The primary objective of the study is to evaluate whether armodafinil at a target dosage of 200 mg/day is more effective than placebo treatment in improving excessive sleepiness in patients with obstructive sleep apnea/hypopnea…
- Conditions
- Sleep Disorders, Obstructive Sleep Apnea, Major Depressive Disorder, Dysthymic Disorder
- Trial name
- NCT00518986
- Testing
- armodafinil
- Where
- 62 sites in United States
- Volunteers
- 249 people
- Sponsor
- Cephalon
Difficult Intubation, Airway Obstruction
Risk Prediction of Difficult Tracheal Intubation in OSAHS Patient
This study evaluates the risk factors for difficult tracheal intubation in in obstructive sleep apnea hypopnea syndrome(OSAHS) patients undergoing uvulo-palato-pharyngoplast(UPPP)
- Trial name
- OSAHS (NCT04506346)
- Testing
- difficult tracheal intubation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Ischemic Stroke, Sleep Apnea Syndrome
Screening and Treatment of SAHS in Patients With Acute Ischemic Stroke
Ischemic stroke is a kind of common disease with great harm. In acute stage of stroke there is sharply increasing morbidity of sleep apnea hypopnea syndrome.
- Trial name
- SAHS (NCT02029183)
- Testing
- Bi level positive pressure ventilation, bi-level positive airway pressure
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University