Clinical trials: Apnea, Sleep
Alzheimer's Disease, Obstructive Sleep Apnea
Role of Hypoxia Ans Sleep Fragmentation in Alzheimer's Disease. and Sleep Fragmentation.
Alzheimer's Disease (AD) is the most prevalent neurodegenerative disease, manifested as an initial deficit of episodic memory that evolves into a global cognitive and psychosocial dysfunction and which prevalence is increasing…
- Trial name
- NCT02814045
- Where
- 2 sites in Spain
- Volunteers
- 144 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Obesity, Diabetes
Ketogenic Diet Treatment of Obesity With Co-morbid Type 2 Diabetes Mellitus and/or Obstructive Sleep Apnea
The purpose of the study is to evaluate the efficacy and safety of ketogenic diet (KD) treatment of (i) obesity, (ii) type 2 diabetes mellitus and (iii) obstructive sleep apnea (OSA) in patients with obesity and Type 2 DM and in…
- Conditions
- Obesity, Diabetes, Obstructive Sleep Apnea
- Trial name
- KGDobesity (NCT02069197)
- Testing
- Ketogenic diet, Orlistat, Standardized diet
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
Obstructive Sleep Apnea
Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices
The hypothesis of the study is that a bibloc-apnea splint has a comparable efficacy on respiratory measures as a monobloc-apnea splint and that the cost of treatment is the same.
- Trial name
- NCT02148510
- Testing
- Monobloc, Bibloc
- Where
- 2 sites in Sweden
- Volunteers
- 313 people
- Sponsor
- Uppsala University
Obesity Hypoventilation Syndrome (OHS)
Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome Patients
Obesity Hypoventilation Syndrome (OHS) is a disease characterized by daytime hypercapnia and sleep-related respiratory disturbances in individuals with a body mass index (BMI) greater than 30 kg/m², without any other condition…
- Trial name
- NCT06766110
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul University - Cerrahpasa
Pediatric Obstructive Sleep Apnea
The Use of Psychomotor Vigilance Testing in the Assessment of Pediatric Obstructive Sleep Apnea
Obstructive sleep apnea results in decreased attentiveness and response times in patients. The objective of this study is to quantify these consequences in pediatric OSA patients using an already established tool for examining…
- Trial name
- PVT (NCT01276860)
- Testing
- Psychomotor Vigilance Testing
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Obstructive Sleep Apnea-hypopnea, Oropharyngeal Cancer
Prevalence of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Following Squamous Cell Carcinomas of the Oropharynx Treatment by Combined Chemoradiotherapy
The study's aim is to determinate the prevalence of obstructive sleep apnea hypopnea syndrome after treatment by combined chemoradiotherapy in a locally advanced stages treated population of oropharyngeal cancer.
- Trial name
- COROSAS (NCT04440618)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Poitiers University Hospital
Tinnitus, Hearing Disorders
Evaluation of Potential Causes of Nap Modulated Tinnitus
The proposed research is a non-interventional study made to evaluate different measurements on 1 group of participants, before and after taking a nap, aiming to potentially guide future investigations on nap-modulated tinnitus to…
- Conditions
- Tinnitus, Hearing Disorders, Ear Diseases, Otorhinolaryngologic Diseases
- Trial name
- TinniNap (NCT05467059)
- Testing
- Napping
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Robin Guillard EIRL
Sleep-disordered Breathing
The 1 Year Follow-up Objective Oral Appliance Compliance
The investigators will perform a 1-year clinical trial measuring objective compliance during mandibular advancement device (MAD) treatment.
- Trial name
- NCT01533623
- Testing
- Mandibular Advancement Device
- Where
- Belgium
- Volunteers
- 51 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea Syndrome, Obesity
Influence of nCPAP on Metabolic Consequences Associated With OSAS
Context: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity. Recurrent episodes of occlusion of upper airways during sleep result in hormonal changes that may predispose to high cardiovascular…
- Trial name
- NCT00435643
- Testing
- nasal continuous positive airway pressure
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Perennial Allergic Rhinitis
Study of Nasonex® in Improving Sleep Disturbances Related to Perennial Allergic Rhinitis (Study P04909)(TERMINATED)
This study will hope to show that the treatment of the patient's perennial allergic rhinitis (PAR) using Nasonex® (mometasone furoate nasal spray) will result in improvement of the nasal symptoms of PAR and of nighttime…
- Trial name
- NCT00491374
- Testing
- Mometasone Furoate Nasal Spray
- Sponsor
- Schering-Plough
Obstructive Sleep Apnea (OSA), Down Syndrome
Endotype DIrected Treatment for OSA in Down Syndrome
Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep.
- Trial name
- EDIT OSA (NCT07280468)
- Testing
- ato-oxy, Oxygen
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Sleep Apnea, Obstructive
Obstructive Sleep Apnea Syndrome (OSA) and Getemed
It is often clinically impossible to differentiate children with an isolated snoring from those with OSA. The diagnosis of OSA is currently based on nocturnal, laboratory-based polysomnography.
- Trial name
- GETEMED (NCT01720823)
- Testing
- home polysomnography (GETEMED), standard polysomnography (BRAINNET II)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Hospices Civils de Lyon
Obstructive Sleep Apnea (OSA) and Obesity
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of HDM1005 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Not Receiving Positive Airway Pressure (PAP) Therapy
This is a 56-week randomized, double blinded, parallel-controlled study evaluating the efficacy and safety of the HDM1005 in patients with obstructive sleep apnea (OSA) and obesity not receiving positive airway pressure (PAP)…
- Trial name
- NCT07787260
- Testing
- HDM1005
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Sleep Apnea, Stroke
Effect Of Early C-PAP Treatment For Sleep Apnea On Rehabilitation Of Stroke Patients
This is a prospective randomized open label trial with control-to-treatment cross-over. The investigators wish to assess the effectiveness and safety of immediate detection and treatment for Sleep Apnea in Stroke patients.
- Trial name
- NCT02426424
- Testing
- Watchpat, CPAP
- Sponsor
- Soroka University Medical Center
Obstructive Sleep Apnea, Adherence
Effort-based Decision-making and CPAP Adherence
Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an…
- Trial name
- NCT04557293
- Testing
- Continuous Positive Airway Pressure (CPAP) treatment
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Sleep Apnea Syndromes
Decrease Obstructive Sleep Apnea (OSA) Sympathetic Tone : Impact of APAP vs CPAP
The present study aims to compare muscle sympathetic neural activity by microneurography after one month treatment of fixed versus auto-adjusting CPAP treatment and its impact on arterial blood pressure
- Trial name
- APAP-CPAP (NCT03428516)
- Testing
- Fixed CPAP, Auto-adjusting CPAP
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Grenoble
Sleep Apnea Syndromes
Mandibular Movement Test as a Screening Tool for Polysomnography Candidates
The primary objective of this study is to determine the technical failure and inconclusive test rates when using the Brizzy device for mandibular movement tracking.
- Trial name
- dépist-By (NCT03129984)
- Testing
- Mandibular movement tracking
- Volunteers
- 4,231 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea
Nasal Expiratory Resistance in Patients With Sleep Apnea and Expiratory Flow Limitation
Obstructive sleep apnea (OSA) is inherently site-specific. In a physiological controlled intervention study, the investigators seek to determine whether applying expiratory resistance can acutely improve ventilation and sleep in…
- Trial name
- ExpFLOSA (NCT02612038)
- Testing
- Expiratory resistance
- Sponsor
- Brigham and Women's Hospital
Sleep Disordered Breathing, Able Bodied
Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive…
- Trial name
- CSA (NCT04118387)
- Testing
- Acetazolamide + supplemental oxygen + PAP therapy, Zolpidem + PAP therapy, Buspirone + PAP therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development