Clinical trials: Apnea, open to volunteers
Obstructive Sleep Apnea Syndrome
Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration.
- Trial name
- IRM SAOS (NCT05147649)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Obstructive Sleep Apnea
Long-term CPAP Effect with Obstructive Sleep Apnea: a Telemedicine-based
we hypothesize that long-term CPAP could results in increase weight and muscle composite by changing intake content and hormone and the effect was influenced by presence of CVD, social jet lag, and CPAP compliance.
- Trial name
- MSLS-LT (NCT06738940)
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Sleep Apnea, Sleep Apnea, Obstructive
Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine
This study will investigate if an intra-nasal nose spray of the drug oxytocin can decrease the amount of pressure needed from the automatic Continuous Positive Airway Pressure (CPAP) device while sleeping decreasing some of the…
- Trial name
- NCT03860233
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vivek Jain
Obstructive Sleep Apnea
Acoustic OSA Prediction During Wakefulness and Monitoring During Sleep
The purpose of this study is to investigate the feasibility of sound analysis for: a) sleep apnea detection both during wakefulness and sleep, and b) flow-sound relationship during both wakefulness and sleep in patients and…
- Trial name
- NCT04112927
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity, Overweight
AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea.
- Conditions
- Obesity, Overweight, Obstructive Sleep Apnoea
- Trial name
- AMAZE 3 (NCT07571005)
- Testing
- NNC0487-0111
- Where
- 80 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
OSAS (Obstructive Sleep Apneas Syndrome), DISE
The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy
This study seeks to compare the clinical efficacy and safety of the novel sedative Remimazolam with Dexmedetomidine in Drug-Induced Sleep Endoscopy (DISE), evaluating their performance in sedation depth stability, incidence of…
- Conditions
- OSAS (Obstructive Sleep Apneas Syndrome), DISE, Sedation
- Trial name
- NCT07459322
- Testing
- Remimazolam, Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University Hospital
Obstructive Sleep Apnea
Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives
OSANOVA is a non-randomized clinical trial which aims to compare outcomes of mandibular advancement device (MAD) and hypoglossal nerve stimulation (HGNS) therapies in moderate-to-severe OSA patients who fail, decline, or are…
- Trial name
- OSANOVA (NCT07074288)
- Testing
- MAD, HGNS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Sleep Apnea, Chronic Nasal Congestion
Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea
The addition of intranasal oxymetazoline for two weeks to already instituted optimal doses of intranasal fluticasone propionate will decrease the total number of obstructive apneas and hypopneas per hour of sleep in subjects with…
- Trial name
- NCT02630121
- Testing
- Oxymetazoline Hydrochloride
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of South Florida
Infant, Premature, Intubation, Intratracheal
Fentanyl and Rocuronium for Tracheal Intubation in Newborns
Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen…
- Conditions
- Infant, Premature, Intubation, Intratracheal, Respiratory Distress Syndrome, Newborn, Apnea of Prematurity
- Trial name
- NEORIN (NCT07650552)
- Testing
- Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- UEA - Universidade Do Estado Do Amazonas
Lumbar Disc Herniation, Obstructive Sleep Apnea Risk Management
Daytime vs Evening Rehabilitation in Lumbar Disc Herniation Patients at High Risk for Obstructive Sleep Apnea
Lumbar disc herniation is a common musculoskeletal condition that negatively affects quality of life, physical function, and daily activities.
- Trial name
- REHAB-TIME (NCT07522021)
- Testing
- Physiotherapy and Exercise Program
- Volunteers
- 60 people
- Sponsor
- Mardin Artuklu University
Obstructive Sleep Apnea, Sleep Apnea
Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry
Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea
- Trial name
- B-HNS (NCT06332404)
- Testing
- Hypoglossal nerve stimulation Inspire system (Inspire Medical Systems Inc., USA)
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- University Hospital, Antwerp
Pulmonary Disease, Chronic Obstructive
Efficacy of Self-titration of Ventilation in Overlap Syndrome (chronic Obstructive Pulmonar Disease + Sleep Apnea Syndrome ) with Dynamic Hyperinflation. EDIN-IDIN.
The combination of COPD and obstructive sleep apnea (OSA) can lead to undesirable interactions with the treatment approach. The investigators know that continuous positive airway pressure (CPAP) can increase dynamic…
- Trial name
- EDIN-IDIN (NCT06713486)
- Testing
- Fixed pressure obtained in the polysomnography for 28 days, Dynamic pressure in Dreamstation AVAPS-AAM PhilipsRespironic® mode
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Normotensive, Sleep Apnea, Obstructive
Normotensive OSA Patients With Dipper Circadian Blood Pressure Pattern
The principal objective is to evaluate the effect of CPAP treatment on blood pressure (BP) in normotensive patients with dipper circadian pattern with sleep apnea-hypopnea syndrome (SAHS).
- Trial name
- NCT03948373
- Testing
- CPAP treatment
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea (OSA), Orofacial Myofunctional Disorders
Oromyofunctional Training: an Innovative Rehabilitation Program for Pediatric Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a prevalent medical condition with important implications for overall health and quality of life in both children. Therefore, it is important to treat OSA early and effectively.
- Trial name
- OROFIT (NCT07129967)
- Testing
- Orofacial myofunctional therapy
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- University Ghent
Goiter
Effects of Thyroidectomy on Obstructive Sleep Apnea in Patients Suffering From Goiters
Literature regarding effects of goiter on the occurrence of obstructive sleep apnea (OSA) remains scarce. Reports have described cases of OSA in patients suffering from goiters, resolved after thyroidectomy.
- Trial name
- NCT05391945
- Testing
- polysomnography
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Obstructive Sleep Apnea
Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy
This clinical trial will evaluate the effect of treatment with hypoglossal nerve stimulation on the underlying mechanisms of obstructive sleep apnea.
- Trial name
- HNS-CoDSE (NCT07337239)
- Testing
- Additional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Severe Label Expansion for EVO Products Trial
Title: Severe Label Expansion for EVO Positioner (SLEEP) Study Description: Single-arm study to determine the safety and effectiveness of treating severe obstructive sleep apnea using the EVO Sleep and Snore Device (ProSomnus…
- Trial name
- SLEEP (NCT07090395)
- Testing
- EVO Sleep and Snore Device
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- ProSomnus Sleep Technologies
Obstructive Sleep Apnea (OSA)
Digital-supported Orofacial Myofunctional Therapy in OSA
This pilot study explores the feasibility, acceptability, and preliminary effectiveness of Digital-supported Orofacial Myofunctional Therapy (d-MFT), an innovative program combining facial recognition technology with…
- Trial name
- NCT07292922
- Testing
- Digital-supported Orofacial Myofunctional Therapy
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hong Kong Metropolitan University
Anesthesia, Airway Complication of Anesthesia
Apnoeic Oxygenation During Pediatric Tracheal Intubation
The goal of this randomized, controlled, single-blinded clinical trial is to evaluate the effectiveness of apnoeic Oxygenation in pediatric anesthesia.
- Conditions
- Anesthesia, Airway Complication of Anesthesia, Anesthesia; Adverse Effect
- Trial name
- NCT06576596
- Testing
- apnoeic Oxygenation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Heidelberg