Clinical trials: Apnea (Central and Obstructive)
OSA - Obstructive Sleep Apnea, Obesity
A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy
The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA but not receiving PAP
- Trial name
- NCT07387094
- Testing
- XW003 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Sleep Apnea Syndromes, Cerebral Infarction
The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression
The investigators hypothesize that trazodone does not worse nocturnal oxygen saturation in insomnic ischemic stroke patients with obstructive sleep apnea (OSA) and depression and has beneficial effect in selected stroke patients…
- Trial name
- NCT04162743
- Testing
- Trazodone
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Fatigue Symptom
Sleep-Disordered Breathing in the Acute Phase After Stroke and Neuropsychiatric Outcomes
In people who have had a stroke or a transient ischemic attack (TIA), it is common to have problems with breathing patterns during sleep, particularly a condition called obstructive sleep apnea.
- Conditions
- Stroke, Fatigue Symptom, Obstructive Sleep Apnea, Sleep Disordered Breathing (SDB)
- Trial name
- NCT06811948
- Where
- Sweden
- Volunteers
- 340 people
- Sponsor
- Blekinge County Council Hospital
COPD, Hypertension
Sleepiz One+ Versus Capnography and Electrocardiography
EtCO2, or exhaled carbon dioxide, is a non-invasive and commonly used measure for respiratory rate and function. It can be easily monitored using a device called a capnograph, which consists of a sensor that is placed near the…
- Conditions
- COPD, Hypertension, Sleep Apnea, Asthma
- Trial name
- SPZCAP (NCT05712226)
- Testing
- Sleepiz One+
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sleepiz AG
Stroke, Sleep-disordered Breathing
Apnea, Stroke and Incident Cardiovascular Events
This prospective cohort study aims to compare the proportion of cardiac or cerebrovascular events after a first stroke, a first transient ischemic attack (TIA) or recurrent TIA, between sleep-disordered breathing (SDB) and…
- Conditions
- Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive
- Trial name
- ASCENT (NCT04399200)
- Testing
- Treatment according to standard care recommandation
- Where
- France
- Volunteers
- 1,620 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
This trial is conducted in North America. The aim of the trial is to investigate the effect of liraglutide in obese subjects with sleep apnoea.
- Conditions
- Metabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea
- Trial name
- NCT01557166
- Testing
- liraglutide
- Where
- 42 sites in United States, Canada
- Volunteers
- 359 people
- Sponsor
- Novo Nordisk A/S
Sleep Apnea, Obstructive
Study on the Safety of Drug BAY2586116 and How it Works in Patients With Obstructive Sleep Apnea (a Sleep Disorder Caused by the Narrowing and Collapse of the Airway During Sleep) Including the Blood Level of the Drug and Effect of Its Doses and Routes of Administration
The researchers in this study want to learn how drug BAY2586116 works in patients with obstructive sleep apnea (OSA). OSA is a sleep disorder marked by breathing pauses during sleep due to repetitive obstructions of the upper…
- Trial name
- KOALA (NCT04236440)
- Testing
- BAY2586116 (A1), BAY2586116 (B1), BAY2586116 (B2)
- Where
- Australia
- Volunteers
- 14 people
- Sponsor
- Bayer
Obstructive Sleep Apnea, Spinal Cord Injuries
Obstructive Sleep Apnea Management in People With Spinal Cord Injury
The prevalence of obstructive sleep apnea (OSA) is a significantly higher in people after spinal cord injury (SCI) than in the general population.
- Trial name
- NCT04962165
- Testing
- Mandibular Advancement Device
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital, Motol
Heart Failure, Sleep Apnea Syndromes
Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients
Heart Failure affects 5-6 million Americans and there are about 550 thousand new cases of heart failure every year. There are approximately 3 million hospital admission for acute decompensated heart failure with hospital…
- Trial name
- ARIA-II (NCT00804349)
- Testing
- Autotitrating Positive Airway Pressure
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein Healthcare Network
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Hypertension, Chronic Kidneys Disease
Nocturnal Blood Pressure and Hypertension - Central and Peripheral 24-h Blood Pressure.
A new study have shown that high night time blood pressure (BP) and/or non-dipping (lack of fall in BP during night time) is a strong predictor for the risk of cardiovascular disease and mortality in patients with hypertension.
- Conditions
- Hypertension, Chronic Kidneys Disease, Obstructive Sleep Apnea
- Trial name
- HOSA (NCT02078765)
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
Stroke, Obstructive Sleep Apnea
Burden of Obstructive Sleep Apnea in Stroke (BOSAST)
There are two purposes of this study. The first purpose is to define the frequency of obstructive sleep apnea in stroke survivors as well as its association with fatigue and quality of life.
- Trial name
- BOSAST (NCT00952211)
- Testing
- CPAP, CPAP at sub-therapeutic pressure
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Diego
Ischemic Stroke, Sleep Apnea Syndrome
Screening and Treatment of SAHS in Patients With Acute Ischemic Stroke
Ischemic stroke is a kind of common disease with great harm. In acute stage of stroke there is sharply increasing morbidity of sleep apnea hypopnea syndrome.
- Trial name
- SAHS (NCT02029183)
- Testing
- Bi level positive pressure ventilation, bi-level positive airway pressure
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Transient Ischemic Attack, Stroke
Post-stroke Triage "DOC": Simple Screening for Depression, Obstructive Sleep Apnea and Cognitive Impairment
The purpose of this study is to determine whether simple, evidence-based clinical screening be quickly and feasibly implemented (>85% of patients in an average of <6 minutes) in large-volume urgent transient ischemic attack…
- Conditions
- Transient Ischemic Attack, Stroke, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02007265
- Where
- Canada
- Volunteers
- 1,504 people
- Sponsor
- Sunnybrook Health Sciences Centre
Apnea, Sleep Apnea Syndromes
Oropharyngeal Exercises and Post-Stroke Obstructive Sleep Apnea
This study evaluates the feasibility and effectiveness of an oropharyngeal exercise (O-PE) regimen in treating post-stroke obstructive sleep apnea, as an alternative therapy to continuous positive airway pressure (CPAP).
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Stroke
- Trial name
- NCT04212260
- Testing
- Oropharyngeal exercises
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Heart Failure, Sleep Apnea
The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients
The aim of this study is to compare the effects of Adaptive Servo Ventilation (Bipap® auto SV Advanced) and oxygen therapy in chronic heart failure patients complicated with central sleep apnea.
- Trial name
- NCT01187823
- Testing
- Adaptive servo ventilation, Nocturnal oxygen
- Where
- Japan
- Volunteers
- 43 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Obstructive Sleep Apnoea (OSA)
A Study Assessing Adult Patients Referred to an NHS Sleep Service With Suspected Obstructive Sleep Apnoea. This Study Aims to Compare the Sunrise Wearable Diagnostic Device Performance and Potential Inclusion in a NHS Diagnostic Pathway With Oximetry and WatchPAT Which Are Currently Used.
The goal of this clinical trial is to evaluate whether the Sunrise device (that measure small jaw movements) can improve the diagnosis and management of Obstructive Sleep Apnoea (OSA) in adults (≥ 18 years) referred to a Sleep…
- Trial name
- SOSA (NCT07269483)
- Testing
- WatchPAT 300, Oximetry, Sunrise
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Virginia Hawkins
Sleep Apnea, Obstructive
Obstructive Sleep Apnea (OSA) Treated With a Potassium Channel Inhibitor
The aim of this study in subjects with obstructive sleep apnea is to investigate pharmacodynamics, safety and tolerability after a single nasal administration of BAY2253651 and to evaluate first safety and tolerability of…
- Trial name
- SANDMAN (NCT03603678)
- Testing
- BAY2253651
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 34 people
- Sponsor
- Bayer
Obese, Sleep Apnea, Obstructive
Eval EarlySense Bet Lowenstein Sleeplab
The study objective is to collect heart rate, respiration rate and motion data of patients admitted to sleep lab and to determine the accuracy level of the EarlySense system vs.
- Conditions
- Obese, Sleep Apnea, Obstructive, Central Apnea, Sleep Disorders
- Trial name
- NCT01978340
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- EarlySense Ltd.