Clinical trials: Apneic Oxygenation
Pediatric Obstructive Sleep Apnea
Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep.
- Trial name
- NCT05052216
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sedation Complication, Obesity
Effect of HFNO on Spontaneous Ventilation in Obese Patients During Analgo-sedation for Vitrectomy
Patients suffering from pathology of posterior eye chamber such as diabetic retinopathy, retinal detachment, traumatic eye injury, retained lens fragments, macular hole, pucker, dislocated intraocular lens after cataract surgery…
- Conditions
- Sedation Complication, Obesity, Hypoxic Respiratory Failure, Airway Obstruction, Nasal
- Trial name
- NCT04049240
- Testing
- Device: low-flow nasal oxygenation (LFNO) 18<BMI<30 kg/m2, Device: low-flow nasal oxygenation (LFNO) 30≤BMI<35 kg/m2, Device: low-flow nasal oxygenation (LFNO) BMI≥35 kg/m2
- Where
- Croatia
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Obesity
Effect of Different-Flow High-Flow Nasal Cannula Versus Traditional Face Mask Oxygenation on Safe Apnea Time in Obese Patients
Obesity is a growing global health problem, and patients with obesity are at higher risk of hypoxemia during induction of general anesthesia.
- Trial name
- NCT07843810
- Testing
- Face Mask, High-Flow Nasal Cannula
- Where
- China
- Volunteers
- 147 people
- Sponsor
- The First People's Hospital of Lianyungang
Apneic Oxygenation
Flow Rate Impact on Arterial Carbon Dioxide During THRIVE
Apneic oxygenation describes the process of continuous oxygenation of the blood without breathing efforts. This anesthesia technique has been described in the literature for more than 100 years and is sometimes used under general…
- Trial name
- ThriVent (NCT05234424)
- Testing
- THRIVE
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Uppsala University Hospital
Anesthesia, General, Apnea
High Flow Nasal Cannula for Safe Apnea
This is a prospective randomized controlled trial comparing high flow nasal cannula and buccal oxygenation as method of oxygenation during apnea in children.
- Trial name
- NCT04849520
- Testing
- High flow nasal cannula, Buccal oxygenation
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Sleep Apnea, Obstructive
The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA
Obstructive sleep apnoea (OSA) is a highly prevalent sleep-related breathing disorder associated with adverse cardiovascular outcome. Underlying mechanisms are subject of debate.
- Trial name
- NCT02493673
- Testing
- Continuous positive airway pressure device
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Laryngoscopy, Apnea
High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia
Patients undergoing suspension laryngoscopy under general anaesthesia have oxygen delivered to their lungs through different methods. Inserting a tube in the trachea is the best means for oxygen delivery.
- Conditions
- Laryngoscopy, Apnea, Anesthesia
- Trial name
- OxALa (NCT03472118)
- Testing
- Nasal High Flow Oxygen
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- CMC Ambroise Paré
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Anesthesia, Oxygen Toxicity
Effect of THRIVE During Apneic Oxygenation in General Anesthesia on Biomarkers
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing.
- Trial name
- Bio-THRIVE (NCT03453294)
- Testing
- Apnoeic oxygenation using THRIVE, Endotracheal intubation and mechanical ventilation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Coronary Artery Disease
Breathing-Induced Myocardial Oxygenation Reserve
This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol, combined with a specific breathing maneuver to identify myocardial regions exposed to severe coronary artery stenosis.
- Trial name
- B-MORE-Pilot (NCT03050346)
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Apneic Oxygenation, Endotracheal Intubation
Apneic Oxygenation Including Precipitous Intubations During RSI in the ED
This RCT is testing the efficacy of apneic oxygenation during endotracheal intubation in the emergency department. Currently the standard practice in the ED when performing endotracheal intubation is that some providers use…
- Trial name
- RAPID (NCT03694379)
- Testing
- Apneic oxygenation during endotracheal intubation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rutgers, The State University of New Jersey
Hip-fracture, General Anaesthesia
Regional Versus General Anesthesia for Hip Fracture and Postoperative Oxygenation
With this study, the investigators intend to measure oxygen saturation before and after hip surgery in the context of proximal femur fracture, comparing two types of anesthesia (general or spinal).
- Conditions
- Hip-fracture, General Anaesthesia, Regional Anaesthesia
- Trial name
- REGENERATION (NCT07309575)
- Where
- Portugal
- Volunteers
- 102 people
- Sponsor
- University of Lisbon
Apnea, Ventilation Therapy; Complications
THRIVE Apneic Ventilation With Standardized Airway Management During General Anesthesia.
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) denotes the use of high-flow humidified nasal oxygen system (for example Optiflow®) as an alternative ventilation modality for an anesthetized patient without…
- Conditions
- Apnea, Ventilation Therapy; Complications, Respiratory Acidosis
- Trial name
- NCT03797859
- Testing
- Apneic ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Failure
Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study
Respiratory failure requiring endotracheal intubation occurs in as many as 40% of critically ill patients. Procedural complications including failed attempts at intubation, esophageal intubation, arterial oxygen desaturation…
- Trial name
- FELLOW (NCT02051816)
- Testing
- Video Laryngoscopy, Apneic Oxygenation, Direct Laryngoscopy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University
Difficult Airway, Difficult Airway Intubation
SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation
Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety.
- Conditions
- Difficult Airway, Difficult Airway Intubation, Neonate
- Trial name
- SEALION (NCT06683599)
- Testing
- Apneic oxygenation
- Where
- 4 sites in Australia, Brazil and 2 more
- Volunteers
- 240 people
- Sponsor
- Vinícius C Quintão, MD, MSc, PhD
Apneic Oxygenation
A "Less-rapid" Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the "Duration of Apnea Without Desaturation" in Paralyzed Non-obese and Morbidly Obese Patients?
The study will test the efficacy of the Pentax AWSTM video laryngoscope (VLS) equipped with a P Blade (Figure 1) as the means to provide Apneic Oxygenation (AO) and prolong Duration of Apnea Without Desaturation (DAWD) in…
- Trial name
- NCT02943629
- Testing
- Apneic oxygenation: Eight minute, Without apneic oxygenation, Apneic oxygenation: five minutes
- Sponsor
- Vanderbilt University
Airway Management
Apneic Intubation Critically Ill Children
This study compares the actual standard of care of intubation in Swiss pediatric intensive care units vs the use of apneic oxygenation using either high flow or low flow oxygen to prevent hypoxemia and to prolong apnea time…
- Trial name
- Penguin (NCT04890288)
- Testing
- Interventional randomized controled trial (RCT) comparing two oxygenation methods to reduce desaturation during intubation vs standard of care.
- Where
- 7 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Apnea, Respiration; Arrest
Pre-oxygenation With Facemask Oxygen vs High-flow Nasal Oxygen vs High-flow Nasal Oxygen Plus Mouthpiece Oxygen
Pre-oxygenation increases oxygen reserves in the body to reduce the likelihood of oxygen desaturation on induction of general anaesthesia. Pre-oxygenation with facemask is the commonest method method of pre-oxygenation.
- Conditions
- Apnea, Respiration; Arrest, Anesthesia
- Trial name
- PREOX (NCT04767867)
- Testing
- Pre-oxygenation
- Where
- Ireland
- Volunteers
- 84 people
- Sponsor
- University College Hospital Galway
Anaesthesia, General, Anesthesia, Intravenous
Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing…
- Conditions
- Anaesthesia, General, Anesthesia, Intravenous, Ventilation
- Trial name
- NCT02706431
- Testing
- Hyperventilation
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
Apnea, Postanesthetic, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)
Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.
- Conditions
- Apnea, Postanesthetic, Desaturation of Blood, Apnea, Anesthesia
- Trial name
- optilaryngo (NCT03843580)
- Testing
- optiflow
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen