Clinical trials: Apnoea
Obstructive Sleep Apnea of Adult
Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea
This study will conduct 3 intervention trials with 44 different participants in each trial, with 22 participants will undergo in-laboratory overnight polysomnograms (PSGs) at one night of medication intervention, and the other 22…
- Trial name
- NCT06295562
- Testing
- Atomoxetine 80mg combined with oxybutynin 5mg, Venlafaxine 37.5mg, oxybutynin 5mg combined with trazodone 100mg
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- China Medical University Hospital
Obstructive Sleep Apnea
Long Term Prognosis of Taiwanese Patients With OSA
The purpose of this study is to explore long-term prognosis and to identify the predictors in Taiwanese OSA patients. Validation of the prediction model derived from NHIRD with the database of National Taiwan University Hospital…
- Trial name
- NCT02090023
- Where
- Taiwan
- Volunteers
- 4,000 people
- Sponsor
- National Taiwan University Hospital
Sleep Apnea, Obstructive, Diabetes Mellitus
Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea
The investigators will examine the possible synergistic effects of obstructive sleep apnea (OSA) and type II diabetes mellitus (DM) on vascular functioning by performing a two-part investigation: A cross-sectional study comparing…
- Trial name
- NCT01629862
- Testing
- Continuous positive airway pressure
- Where
- 2 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Sanjay R Patel
Acute Ischemic Stroke, Sleep Apnea
Continuous Positive Airway Pressure for the Treatment of Stroke
New stroke therapies are needed. This study seeks to provide the preliminary data needed to plan a future study that will evaluate the efficacy of using continuous positive airway pressure (CPAP) to treat stroke patients who have…
- Trial name
- NCT00368628
- Testing
- continuous positive airway pressure
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Yale University
Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF)
Clinical Trials for Elderly Patients With Multiple Disease
The CHROMED project focuses its investigation on the applicability of an integrated solution for a pathological condition which: a) is very prevalent in ageing patients and b) severely impairs quality of life: COPD with other…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF), Sleep Disordered Breathing (SDB)
- Trial name
- CHROMED (NCT01960907)
- Testing
- CHROMED monitoring system
- Where
- 6 sites in Estonia, Slovenia and 3 more
- Volunteers
- 312 people
- Sponsor
- Restech Srl
Sleep Apnea Syndromes, Nasal Obstruction
Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea
Obstructive sleep apnea occurs in 2-4% of middle age adults and results in significant morbidity and mortality. The first line therapy is provision of continuous positive airway pressure (CPAP) via a nasal mask chronically.
- Conditions
- Sleep Apnea Syndromes, Nasal Obstruction, Turbinate Hypertrophy
- Trial name
- TURBO (NCT00503802)
- Testing
- Radiofrequency Turbinate Reduction
- Where
- 3 sites in United States
- Volunteers
- 242 people
- Sponsor
- University of Washington
Obstructive Sleep Apnea (OSA)
Vent Flow Study of Prototype Nasal CPAP Mask
As continuous positive airway pressure is the treatment choice for OSA, a mask is vital in ensuring the effectiveness of therapy delivery. The study will evaluate the performance of a new mask system with diffuse vent technology.
- Trial name
- GVFECT (NCT02805777)
- Testing
- CPAP mask
- Sponsor
- ResMed
Sudden Infant Death Syndrome, Apnea
Incidence and Severity of Cardiorespiratory Events in Infants at Increased Epidemiological Risk for Sudden Infant Death Syndrome (SIDS)
OBJECTIVES: I. Assess and compare the incidence and severity of cardiorespiratory events documented by home monitoring in infants at increased epidemiological risk for sudden infant death syndrome (SIDS). II.
- Trial name
- NCT00004392
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obstructive Sleep Apnea, Acute Kidney Failure
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide.
- Conditions
- Obstructive Sleep Apnea, Acute Kidney Failure, Chronic Kidney Disease
- Trial name
- OSA-AKI (NCT00947479)
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
Complex Sleep Apnea Syndrome
Complex Sleep Apnea Syndrome (CompSAS) Resolution Study
The purpose of this study is to determine whether adaptive servo-ventilation (ASV) or continuous positive airway pressure (CPAP) is better at treating complex sleep apnea over time.
- Trial name
- CompSAS (NCT00915499)
- Testing
- VPAP Adapt SV
- Where
- 6 sites in United States
- Volunteers
- 66 people
- Sponsor
- ResMed
Obstructive Sleep Apnea (OSA)
Personalised Active Self-management of Sleep Apnea Program
This study is to assess the feasibility and acceptability of the PASS in patients with OSA. Second, the study examines its effectiveness in improving PAP uptake and adherence, self-efficacy in self-care, changes in health-related…
- Trial name
- PASS (NCT07494292)
- Testing
- 4-month Personalized and Adaptive Sleep Support program (PASS), Control group
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hong Kong Metropolitan University
Sleep Apnea, Central, Sleep Apnea, Obstructive
Evaluation of ApneaLink Plus Scoring Capabilities
The purpose of this study is to investigate the following topics: Determine the accuracy of ApneaLink Plus in separating Apneas into Obstructive Apneas, Mixed Apneas and Central Apneas.
- Trial name
- NCT00823134
- Testing
- ApneaLink Plus
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- ResMed
Obstructive Sleep Apnea, Morbid Obesity
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of sleep-disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Morbid Obesity, Epigenetic Disorder
- Trial name
- EPIMOOSA (NCT03995836)
- Testing
- CPAP, Bariatric Surgery
- Volunteers
- 70 people
- Sponsor
- Aragon Institute of Health Sciences
Obstructive Sleep Apnea Syndrome
Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
The aim of the project is to evaluate whether therapy with leukotriene may be a valid therapeutic approach in children with adenotonsillar hypertrophy and with mild and moderate obstructive sleep apnea syndrome (OSAS) and to…
- Trial name
- SB-OSAS (NCT00912171)
- Testing
- budesonide (Aircort 50 nasal spray), montelukast (Singulair)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Bologna
Influenza
Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032)
The investigators collected blood and lymphoid tissues routinely discarded during surgery from adults after a routine seasonal influenza vaccination to determine how immune memory develops at the actual site of infection, and how…
- Trial name
- NCT03023709
- Testing
- Fluzone®, FluMist®
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea
Evidence-based Diagnosis and Management of Pediatric Obstructive Sleep Apnea in Primary Care
Obstructive Sleep Apnea (OSA) is prevalent in children and adolescents and associated with a variety of negative consequences affecting health and cognitive functioning.
- Trial name
- NCT02781376
- Testing
- CHICA OSA, Snoring Identification Only
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Indiana University
Hypertension, Metabolic Disorder
The Effects of Obstructive Sleep Apnea and Its Intervention on Coronary Heart Disease
Obstructive sleep apnea(OSA) is an important identifiable cause of hypertension. Previous study has suggested that OSA significantly increases cardiovascular morbidity and mortality, especially in patients with pre-existing…
- Trial name
- NCT02059993
- Testing
- continuous positive airway pressure
- Volunteers
- 83 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Obstructive Sleep Apnea, Obesity
Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)
In this study the investigators will analyze the influence of smoking, benzodizepine use, and obesity among patients with severe Obstructive Sleep Apnea (sOSA).
- Conditions
- Obstructive Sleep Apnea, Obesity, Smoking
- Trial name
- NCT02539264
- Testing
- Smoking, Obesity, Benzodiazepine use
- Volunteers
- 920 people
- Sponsor
- Astes
Snoring, Mouth Breathing
OA Therapy for Mouth-breathers Who Snore
Breathing is one of the body's vital functions that occur under normal conditions using the nose. When humans breathe primarily through the mouth instead of the nose, this is referred to as mouth breathing.
- Conditions
- Snoring, Mouth Breathing, Obstructive Sleep Apnea
- Trial name
- OATMB (NCT04876625)
- Testing
- myTAP oral appliance plus mouth shield, myTAP oral appliance alone for first 4 weeks
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Sleep Apnea Syndromes, Venous Thromboembolism
Sleep Apnea and Tromboembolic Disease
There is some evidence for a hypercoagulable state in sleep apnea-hipopnea syndrome (SAHS), which could play a role in the increased cardiovascular morbility and mortality.
- Trial name
- NCT00501358
- Where
- Spain
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
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