Clinical trials: Apnoea
Obstructive Sleep Apnea Syndrome
Effects of Obstructive Sleep Apnea Treatment by Fixed CPAP and by Auto-CPAP (Somnosmart2)
The main purpose of this study is to investigate if treatment of obstructive sleep apnea syndrome (OSAS) by continuous positive airway pressure (CPAP) given by a traditional CPAP device administering a fixed air pressure, or by…
- Trial name
- NCT00633711
- Testing
- Automatic (variable, automatically controlled) pressure CPAP, fixed continuous positive airway pressure (CPAP)
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Acute Decompensated Heart Failure, Sleep Disordered Breathing
Adaptive Servo Ventilation (ASV) in Heart Failure
Up to 60% of patients with heart failure show abnormal patterns of breathing (sleep disordered breathing (SDB)) at night which can increase the risk of recurrent admissions and have important prognostic implications.
- Trial name
- NCT02440971
- Testing
- S9-Autoset CS-A
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- St Vincent's University Hospital, Ireland
OSA
Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea
Current therapies available for obstructive sleep apnea (OSA) have varying degrees of efficacy due to the complex nature of the disorder.
- Trial name
- NCT05944965
- Testing
- Atomoxetine 80 mg plus Oxybutynin 5 mg, Atomoxetine 80 MG
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Vollunteer, Apnea
Temporal Dynamics of Peripheral SpO₂ During Reoxygenation
Pulse oximeters estimate arterial oxyhaemoglobin saturation (SaO₂) from photoplethysmographic signals recorded at peripheral sites (usually the fingertip), thus measuring the peripheral oxygen saturation (SpO₂).
- Trial name
- PulseOx (NCT07884500)
- Testing
- Voluntary Apnea
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Acid Reflux Disease, Obstructive Sleep Apnea
Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea
The purpose of this study is to determine if using Pantoprazole decreases your daytime sleepiness and improves your reaction time when compared to using a placebo (sugar pill).
- Trial name
- NCT00307944
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Obstructive Sleep Apnea
Safety and Effectiveness of Slow Wave Device for the Treatment of Obstructive Sleep Apnea
This is a safety and efficacy trial for a Slow Wave, Inc. UASD oral appliance for the treatment of Obstructive Sleep Apnea. This trial will recruit 60-80 participants through our IRB partner.
- Trial name
- NCT06519149
- Testing
- Slow Wave UASD
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Slow Wave, Inc.
Obstructive Sleep Apnea
Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation
The objective of the BREATHE study is to demonstrate the continued safety and effectiveness of the Genio® System in treating subjects diagnosed with moderate to severe obstructive sleep apnea (OSA) who are intolerant to or…
- Trial name
- BREATHE (NCT07331285)
- Testing
- This is a single arm study, all consented and eligible subjects will be implanted with the Genio® System 2.1
- Where
- 2 sites in United States
- Volunteers
- 229 people
- Sponsor
- Nyxoah Inc.
Obstructive Sleep Apnea
Serotonin and the Upper Airway in Obstructive Sleep Apnea
The purpose of this study is to determine if a certain medication, alone or combined with another medication, will increase muscle activity in the upper airway in people who do and people who do not have sleep apnea.
- Trial name
- NCT00100464
- Testing
- Paroxetine, 5HTP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Obstructive Sleep Apnea of Adult
Safety and Dosing Study of the CHILLS Cryotherapy for the Treatment of OSA
ARCTIC-1 is a safety and dosing study to evaluate procedure tolerability in patients with clinically diagnosed moderate or severe OSA.
- Trial name
- ARCTIC-1 (NCT04864652)
- Testing
- CHILLS Procedure
- Where
- 2 sites in Panama, Paraguay
- Volunteers
- 84 people
- Sponsor
- Cryosa, Inc.
Apnea, Cardiopulmonary Resuscitation
Head Positions to Open the Upper Airway
Ventilation during basic life support improves survival in cardiac arrest patients significantly. Unfortunately, this is in contrast to the willingness of potential rescuers to perform mouth-to-mouth ventilation.
- Trial name
- NCT00869648
- Testing
- Extension, Neutral head position, Anaesthesiologist's position
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea
Simplus and Eson Non-Invasive Ventilation (NIV) Evaluation - Germany
This investigation is designed to evaluate the performance, comfort and ease of use of the Simplus and Eson masks amongst NIV patients who are currently on Bi-level therapy
- Conditions
- Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
- Trial name
- NCT02726048
- Testing
- Simplus/Eson
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Fisher and Paykel Healthcare
Hypoxia
Apneic Oxygenation During Airway Management in Pediatric Patients
Airway placement after anesthetic induction in pediatric patients is routinely performed at our institution without apneic oxygenation.
- Trial name
- NCT02437864
- Testing
- Supplemental oxygen via nasal cannula
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of New Mexico
Hypertension, Sleep Apnea
Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea
The investigators investigated diastolic function among patients with obstructive sleep apnea (OSA) and hypertension stage I. In this randomized controlled trial, participants were randomly allocated to one of two groups…
- Trial name
- DOSA-2 (NCT02896621)
- Testing
- Chlorthalidone plus amiloride, Amlodipine
- Where
- Brazil
- Volunteers
- 69 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Retinal Vein Occlusion, Obstructive Sleep Apnea
Retinal Vein Occlusion and Obstructive Sleep Apnea: A Case Control Study
This study purpose is to evaluate the association between Retinal Vein Occlusion and Obstructive Sleep Apnea.
- Trial name
- SASOVR (NCT04011358)
- Testing
- Sleeping Monitor
- Where
- France
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sleep Disorder, Sleep Disorder Parasomnia
Mainz Register of Patients With Sleep Disorders
Prospective longitudinal observational registry study of all patients with sleep disorders treated in the Mainz Comprehensive Epilepsy and Sleep Medicine Center with the focus on the course of the disease and quality of life.
- Conditions
- Sleep Disorder, Sleep Disorder Parasomnia, Narcolepsy, Sleep Apnea
- Trial name
- MAINZ-SLEEPREG (NCT05321355)
- Testing
- Implantation of vagus nerve stimulation according to clinical indication
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Johannes Gutenberg University Mainz
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University
Apnea
Ventilation Using a Bag Valve Mask With Integrated Internal Handle
Investigators compared tidal volumes for single rescuer ventilation using a modified bag valve mask with an integrated internal handle versus a conventional bag valve mask in a manikin model.
- Trial name
- NCT02792049
- Testing
- Modified Ambu Spur II bag valve mask, Conventional Ambu Spur II bag valve mask
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Obstructive Sleep Apnoea
Dynamic Alterations of Tongue in Sleep Apnoea Hypopnea Syndrome During Sleep
The aim of this study was to evaluate the dynamic changes of the tongue in patients with obstructive sleep apnoea hypopnea syndrome (OSAHS) during sleep and while awake by using Ultrafast Magnetic Resonance Imaging (UMRI)
- Trial name
- NCT01687855
- Testing
- Ultrafast Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Obstructive Sleep Apnea
Effect of Added Varnum Mouthpiece on Pharyngeal Collapsibility and Sleep Apnea Severity in Mouth Breathers.
Test the effect of added a single-use Varnum mouthpiece on pharyngeal collapsibility and obstructive sleep apnea (OSA) severity in patients who identify themselves as mouth breathers.
- Trial name
- NCT02738255
- Testing
- Varnum mouthpiece
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- David Andrew Wellman
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