Clinical trials: Apnoea
Atrial Fibrillation, Obstructive Sleep Apnea of Adult
the Pathophysiology of the Onset of Atrial Fibrillation in Obstructive Sleep Apnea
Rationale: Obstructive sleep apnea (OSA) is a highly prevalent, often undiagnosed, modifiable risk factor for atrial fibrillation (AF), as well as AF-related complications and treatment effectiveness.
- Trial name
- PARABOLA (NCT06246825)
- Testing
- Polysomnography
- Where
- Netherlands
- Volunteers
- 190 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Pulmonary Arterial Hypertension, Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) in Pulmonary Arterial Hypertension (PAH)
The purpose of this study is to determine whether pulmonary arterial hypertension can worsen or even cause sleep apnea. It is hypothesized that if pulmonary arterial hypertension does indeed worsen or cause sleep apnea, then the…
- Trial name
- NCT01835080
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Vitamin D Deficiency, Obstructive Sleep Apnea
Vitamin D Status in Obstructive Sleep Apnea With and Without Comorbidities
This retrospective observational study evaluates the relationship between vitamin D status and obstructive sleep apnea (OSA) in adults.
- Trial name
- NCT07788391
- Where
- Turkey (Türkiye)
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Sleep Apnea, Obstructive
Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults
In this protocol the investigators will test the effect of dalfampridine (a potassium channel blocker) on genioglossus muscle activity (EMG GG) during wakefulness and sleep in healthy control subjects.
- Trial name
- APIGLOSS (NCT02656160)
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Obstructive, Sleep Disorder
HSAT for OSA Management in Children
This clinical trial will compare the diagnostic accuracy of type II HSAT with PSG for determining OSA status following treatment with adenotonsillectomy in children
- Conditions
- Sleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep Disturbance
- Trial name
- HOM-Kids (NCT05516524)
- Testing
- Home sleep apnea test, PSG
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Children's Hospital of Philadelphia
Sleep Apnea Syndrome (OSAS)
Semaglutide Effects on Sleep Apnea in Patients With Type 2 Diabetes/Obesity and Comorbid Obstructive Sleep Apnea
Semaglutide (a GLP-1RA) is approved for type 2 diabetes mellitus T2DM and obesity, but its effect on obstructive sleep apnea OSA remains unclear.
- Trial name
- NCT07281196
- Testing
- Semaglutide Subcutaneous Injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Fengxian District Central Hospital
Acute Decompensated Heart Failure, Sleep Disordered Breathing
Cardiovascular Improvements With MV ASV Therapy in Heart Failure
The aim of the study is to compare the effects of MV targeted ASV in addition to optimized medical therapy versus optimized medical therapy alone at 6 months in patients with acute decompensated HF.
- Trial name
- CAT-HF (NCT01953874)
- Testing
- MV ASV, Optimized Medical Treatment
- Where
- 15 sites in United States, Germany
- Volunteers
- 126 people
- Sponsor
- ResMed
Snoring, Obstructive Sleep Apnea (OSA)
Validation of a Snoring App Against Commercially Available Applications and PSG
This study will compare the output of a new snoring application against another commercially available application and polysomnography (either home or in-laboratory).
- Trial name
- NCT07097597
- Testing
- Comparison 1: New Snoring Application, Comparison 2: Commercially Available Snoring Application, Comparison 3: Polysomnography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Obstructive Sleep Apnea
Effects of Physical Activity on OSA Severity Based on the Level of Fluid Shift
Obstructive sleep apnea (OSA) is characterized by complete or partial upper-airway collapse during sleep associated with sleepiness.
- Trial name
- AP-FLUID (NCT04623463)
- Testing
- Physical activity intervention
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
keePAP Device for Treatment of Obstructive Sleep Apnea
The aim of the study is to test the hypothesis that a new device would produce a significant decrease in obstructive breathing events during sleep as indexed by the Apnea Hyperpnoea Index (AHI) or Respiratory Disturbance Index…
- Trial name
- NCT01809418
- Testing
- keePAP
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- keepMED Ltd.
Obstructive Sleep Apnea
OROPHARYNGEAL MYOFUNCTIONAL THERAPY IN OBSTRUCTIVE SLEEP APNEA
Obstructive Sleep Apnea (OSA) is a prevalent nocturnal breathing disorder among the general population. Oropharyngeal myofunctional therapy (OMT) is an alternative conservative treatment used to improve OSA, associated health…
- Trial name
- NCT06681974
- Testing
- CONTROL:Information form with hygienic-dietary measures or sleep hygiene guidelines is provided and explained., EXPERIMENTAL: program of exercises that will be composed of 4 blocks
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Obstructive Sleep Apnea of Adult
A Pilot Study of Antioxidant Therapy in Obstructive Sleep Apnea Patients
Sleep apnea is a common under-diagnosed medical disorder, and moderate to severe disease is found in approximately 9% of men and 4% of women.
- Trial name
- NCT05009901
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablet
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Cardiovascular Diseases, Heart Diseases
Outcomes of Sleep Disorders in Older Men
To determine the effects of sleep disorders on cardiovascular function and disease in older men.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Sleep, Sleep Apnea Syndromes
- Trial name
- NCT00070681
- Testing
- Polysomnography
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Effect of ISABel Bed 1 Ans ISABel Bed 2
ISABel: Intelligent Sleep Apnoea Bed
The aim of this trial is to assess the effect of two automated beds on severity of POSA as well as the feasibility of these beds as POSA treatment.
- Trial name
- ISABel (NCT04713267)
- Testing
- ISABel Bed 1
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Swiss Federal Institute of Technology
Obstructive Sleep Apnea, Chronic Tonsillitis
Effect of OSA Resulting From Chronic Tonsillitis on Pregnancy Outcomes
This cohort study aims to investigate the impact of obstructive sleep apnea hypopnea syndrome (OSA) resulting from chronic tonsillitis on pregnancy outcomes.
- Conditions
- Obstructive Sleep Apnea, Chronic Tonsillitis, Pregnancy
- Trial name
- NCT06391151
- Testing
- exposure: OSA resulting from chronic tonsillitis
- Volunteers
- 500 people
- Sponsor
- Peking University First Hospital
Apnea, Sleep, Chronic Fatigue Syndrome
Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
The purpose of this study is to determine any sleep disordered breathing in veterans with Gulf War Syndrome (GWS) and compare it to healthy normal asymptomatic Gulf War veterans.
- Trial name
- NCT00252629
- Testing
- Nasal CPAP treatment during sleep
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- US Department of Veterans Affairs
Hypertensive Disorder of Pregnancy, Sleep-disordered Breathing
Association of Hypertensive Disorder of Pregnancy With Sleep-disordered Breathing.
This study aims to assess the prevalence of sleep disorder breathing in pregnant women with a singleton gestation who develop hypertensive disorder of pregnancy (HDP) compared to women without HDP, when matched for gestational…
- Trial name
- NCT04126629
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cooper Health System
Sleep Apnea, Obstructive
The Effect of Telemedicine-Based APAP Management on 24-Hour Ambulatory Blood Pressure in Patients With Obstructive Sleep Apnea
Epidemiological studies have shown that OSA is closely related to the occurrence and development of cardiovascular diseases, especially hypertension.
- Trial name
- NCT06064630
- Testing
- Automatic continuous positive airway pressure
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Peking University People's Hospital
Snoring, OSA - Obstructive Sleep Apnea
Serene Sleep Palatal Implant System Clinical Confirmatory Trial in Participants Who Snore or Are Diagnosed With Mild-to-moderate Obstructive Sleep Apnea (OSA).
This clinical investigation is a prospective, non-randomized, parallel-group clinical investigation conducted at two (2) investigative sites.
- Trial name
- NCT07613281
- Testing
- Palatal Implant System
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Serene Sleep, Inc.
Apneic Oxygenation
A "Less-rapid" Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the "Duration of Apnea Without Desaturation" in Paralyzed Non-obese and Morbidly Obese Patients?
The study will test the efficacy of the Pentax AWSTM video laryngoscope (VLS) equipped with a P Blade (Figure 1) as the means to provide Apneic Oxygenation (AO) and prolong Duration of Apnea Without Desaturation (DAWD) in…
- Trial name
- NCT02943629
- Testing
- Apneic oxygenation: Eight minute, Without apneic oxygenation, Apneic oxygenation: five minutes
- Sponsor
- Vanderbilt University
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