Clinical trials: Apnoea
Alternative Method of Apnea Test
Comparison of Two Strategies to Realize Apnea Test for the Diagnostic of Brain in Potentiel Organ Donors.
Clinical diagnostic of brain death requires a non-reactive coma, absence of brain stem reflex, and absence of spontaneous breathing.
- Trial name
- APNEE REA (NCT01911286)
- Testing
- Apnea test - Standard, Apnea test - CPAP
- Where
- 17 sites in France
- Volunteers
- 208 people
- Sponsor
- Poitiers University Hospital
Osa Syndrome
Effects of Exercise on Sleep Quality in Patients With Obstructive Sleep Apnea Syndrome
the investigators aim in this study is to investigate the effects of aerobic and oropharyngeal exercises on sleep quality in patients with Obstructive Sleep Apnea Syndrome (OSAS).
- Trial name
- NCT06006520
- Testing
- control, oro-granary exercises., aerobic exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uskudar University
Obstructive Sleep Apnea
Device-Assisted Oropharyngeal Rehabilitation in Obstructive Sleep Apnea Patients Using Continuous Positive Airway Pressure
The goal of this clinical trial is to evaluate the effectiveness of device-assisted oropharyngeal rehabilitation (OPR) in improving upper airway muscle function and reducing obstructive sleep apnea (OSA) severity in adult…
- Trial name
- NCT06999746
- Testing
- Control, Oropharyngeal Exercise, Continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
OSA
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
This prospective observational study will enroll 60 moderate-to-severe OSA patients (AHI≧15/hour, 30 obese [BMI>=27] \& 30 non-obese [BMI<27]) and 40 age-, gender-, BMI-matched controls without OSA.
- Trial name
- NCT05485688
- Testing
- sleep apnea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Apnea Infant
Clinical Assessment of the BreathAlert Device in Monitoring Apneic Episodes
A team of researchers at Rice University in partnership with clinicians at Queen Elizabeth Central Hospital created BreathAlert, a low cost battery-powered monitor that detects and corrects apnea.
- Trial name
- NCT07704320
- Testing
- BreathAlert (low cost respiratory rate and apnea monitor)
- Where
- Malawi
- Volunteers
- 60 people
- Sponsor
- William Marsh Rice University
Obstructive Sleep Apnea
Muscle Stimulation During DISE
Drug-induced sleep endoscopy (DISE) is a widely used tool for assessing collapse patterns of the upper airway anatomy during sleep.
- Trial name
- NCT03589846
- Testing
- Grass S88 Muscle Stimulator
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea
Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea
Incomplete recovery of neuromuscular function after surgery can lead to respiratory complications. Patients with obstructive sleep apnea (OSA) are prone to respiratory complications after surgery.
- Trial name
- NCT02160223
- Testing
- Sugammadex, Neostigmine
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Diskapi Teaching and Research Hospital
Sleep Disordered Breathing, Cheyne-Stokes Respiration
Feasibility Study to Determine the Effects of Phrenic Nerve Stimulation in Patients With Periodic Breathing
The purpose of this feasibility study is to determine the effect of stimulating the phrenic nerve to treat periodic breathing (a pattern of breathing characterized by hyperpneas followed by hypopneas or apneas).
- Conditions
- Sleep Disordered Breathing, Cheyne-Stokes Respiration, Sleep Apnea
- Trial name
- NCT00909259
- Testing
- Phrenic stimulation device
- Where
- 5 sites in United States, China and 1 more
- Volunteers
- 50 people
- Sponsor
- Respicardia, Inc.
Obstructive Sleep Apnea
CPAP Effect on Vascular Function in Obstructive Sleep Apnea
Obstructive sleep apnea syndrome is responsible of endothelial dysfunction, which is a independent cardio-vascular risk factor. Assessment of pulse wave velocity (PWV) and peripheral arterial tone (PAT) are study measurements of…
- Trial name
- VNI-SOH2 (NCT02623088)
- Testing
- PAP Therapies (CPAP)
- Where
- France
- Volunteers
- 107 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Dextrose Prolotherapy Versus LLLT in Treatment of Obstructive Sleep Apnea
This study was conducted on 26 patients with obstructive sleep apnea. The patients were divided randomly and equally into two equal groups.
- Trial name
- NCT06427161
- Testing
- LLLT application, dextrose injection
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Mansoura University
Apnoeic Oxygenation
Positive Airway Pressure Under Apnoeic Oxygenation With Different Flow Rates in Nasal Cannula Therapy
The main objective of this explorative observational study is to investigate the pressures in infraglottic airway and the pharynx provided by THRIVE , using flows ranging from 1l/min to 80 l/min, in patients hospitalized for…
- Trial name
- PAPUA-Flow (NCT03738722)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obstructive Sleep Apnea
Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea
The purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate…
- Trial name
- NCT01446601
- Testing
- Hypoglossal Nerve Stimulation (HGNS) System (Apnex Medical )
- Where
- 14 sites in United States, Australia
- Volunteers
- 132 people
- Sponsor
- Apnex Medical, Inc.
Sleep Apnea Syndromes
Cardiovascular Impact, Quality e Quantity of Sleep in Bed Partners of Patients With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common clinical condition associate with a negative impact not limited to the patients but also to the partner that sleep in the same bed.
- Trial name
- SLEEP-PARTNERS (NCT03011294)
- Testing
- Continuous positive airway pressure (CPAP), Nasal strip
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea, ST Elevation Myocardial Infarction
CPAP for OSA on Myocardial Salvage After pPCI for STEMI Patients
The aim of this randomized controlled trial to investigate the effects of CPAP treatment on myocardial salvage index and clinical outcomes at 3 months in patients with OSA and ST-Segment Elevation Myocardial Infarction (STEMI)…
- Trial name
- NCT03444857
- Testing
- Continuous positive airway pressure
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Anzhen Hospital
Chronic Heart Failure, Central Sleep Apnea
Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration
Sleep disordered breathing is common in patients with chronic heart failure. Adaptive servoventilation is a novel method of treatment central sleep apnoea, especially associated with Cheyne-Stokes-respiration.
- Conditions
- Chronic Heart Failure, Central Sleep Apnea, Cheyne-Stokes Respiration
- Trial name
- NCT01212705
- Testing
- Adaptive servoventilation
- Where
- Poland
- Sponsor
- Military Institute od Medicine National Research Institute
Alzheimer's Disease, Obstructive Sleep Apnea
Sleep in Adults With Down Syndrome and Alzheimer's Disease
RATIONALE of the project. Adults with Down syndrome (DS) present severe sleep disorders that are under recognized by caregivers.
- Conditions
- Alzheimer's Disease, Obstructive Sleep Apnea, Sleep Disturbances
- Trial name
- NCT03942341
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Apnea, Ventilation Therapy; Complications
THRIVE in Children at Different Flow Rates
This study investigates under controlled circumstances the concept of THRIVE to improve the ventilation and the carbon dioxide elimination, to prolong the apnoea time without deoxygenation and to improve safety of airway…
- Trial name
- NCT03812354
- Testing
- THRIVE 4L/kg/min, THRIVE 2L/kg/min
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anesthesia, Oxygen Toxicity
Effect of THRIVE During Apneic Oxygenation in General Anesthesia on Biomarkers
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing.
- Trial name
- Bio-THRIVE (NCT03453294)
- Testing
- Apnoeic oxygenation using THRIVE, Endotracheal intubation and mechanical ventilation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Central Sleep Apnea, Cheyne-Stokes Respiration
Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT)
To investigate whether nHFT is an effective treatment for patients with Chronic Heart Failure (CHF) and central sleep apnea (CSA).
- Trial name
- RELAX (NCT03085641)
- Testing
- Nasal high flow oxygen therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
Analgesia, Recovery, Psychological
Enhanced Recovery After Uvulopalatoplasty
Obstructive sleep apnea is a prevalent condition often treated surgically with palatoplasty, which improves airway patency and reduces apneic events.
- Trial name
- NCT07246694
- Testing
- Glossopharyngeal nerve block, Standard multimodal analgesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
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