Clinical trials: Apnoea
Obstructive Sleep Apnea of Child
Diaphragm Ultrasound İn Children With OSAS
This is a prospective observational study evaluating perioperative diaphragmatic function by ultrasonography in children aged 1-12 years undergoing elective surgery under general anesthesia.
- Trial name
- NCT07380321
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Sleep Apnea, Obstructive
Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea
Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients.
- Trial name
- NCT00695214
- Testing
- Propofol sedation
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of California, Los Angeles
Obstructive Sleep Apnea, Sleep Apnea
Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry
Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea
- Trial name
- B-HNS (NCT06332404)
- Testing
- Hypoglossal nerve stimulation Inspire system (Inspire Medical Systems Inc., USA)
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- University Hospital, Antwerp
Sleep Apnea, Obstructive, Hypertension
Mechanisms for Individual Differences in Hypertension in Obstructive Sleep
Hypertension is a common consequence of obstructive sleep apnea (OSA). However, not all individuals with OSA have hypertension and there are major individual differences in blood pressure response to positive airway pressure…
- Trial name
- PISA-BP (NCT03176732)
- Testing
- Positive Airway Pressure
- Where
- 2 sites in United States, Iceland
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep Apnea Syndrome
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.
- Trial name
- NCT00746928
- Testing
- Chronic Intermittent Hypoxia
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Sleep Apnea
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study B
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood.
- Trial name
- NCT01738009
- Testing
- Induction of flow limitation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Central Sleep Apnea
Pathophysiological Study of CSA in Adults With pLVEF
Sleep apnea is classically divided into obstructive and central apnea, according to the persistence or otherwise of respiratory movements and the existence or not of pharyngeal collapse during apnea.
- Trial name
- PHENOSAX (NCT03919344)
- Testing
- Critical airway closure pressure (Pcrit) measurment, Acoustic pharyngometry, High density surface electroencephalogram neural mapping
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Airway Obstruction, Obstructive Sleep Apnea
Relationship Between STOP BANG Score and Airway Management
Nowadays, anesthetists may encounter many patients who are not diagnosed with obstructive sleep apnea syndrome (OSAS) to undergo elective surgery.
- Conditions
- Airway Obstruction, Obstructive Sleep Apnea, Hypoxia
- Trial name
- NCT05640856
- Testing
- intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Sleep Apnea, Obesity
Sleep Apnea in Pregnancy Screening Study
Obstructive sleep apnea is known to be a significant source of morbidity in the general population. It has been proposed to be associated with the development of preeclampsia and fetal growth restriction.
- Trial name
- SAPSS (NCT01585844)
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Sleep Disordered Breathing, Apnea of Prematurity
The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study
Diagnostic investigations in paediatric respiratory and sleep medicine are often challenging due to patient size (due to prematurity), tolerability, and compliance with "gold standard equipment".
- Conditions
- Sleep Disordered Breathing, Apnea of Prematurity, Respiratory Rate, Sudden Unexpected Death in Epilepsy
- Trial name
- PARS (NCT06292299)
- Testing
- Pneumowave
- Where
- 2 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- NHS Greater Clyde and Glasgow
Obstructive Sleep Apnea
Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry
Inspire intends to conduct this registry to: 1) collect Inspire therapy clinical evidence in the clinical practice setting; 2) collect additional information on the effectiveness, use and safety in the commercial setting; and 3)…
- Trial name
- NCT02907398
- Testing
- Inspire therapy, No intervention
- Where
- 64 sites in United States, Belgium and 3 more
- Volunteers
- 5,000 people
- Sponsor
- Inspire Medical Systems, Inc.
Colorectal Cancer, Sleep Apnea Syndromes
Prevalence of Sleep Apnea in Patients Undergoing Surgery for Colorectal Cancer
212 patients with colorectal cancer will be investigated before surgery and 100 of them after surgery. 597 individuals from a previous population based study will serve as controls to the prevalence of sleep apnea in the general…
- Conditions
- Colorectal Cancer, Sleep Apnea Syndromes, Hypoxia
- Trial name
- NCT02323464
- Testing
- Surgery for colorectal cancer, No Interventions
- Where
- Sweden
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Karl A Franklin
Sleep Apnea Syndromes, Lung Diseases
Family Linkage Study of Obstructive Sleep Apnea (OSA) in Iceland
To study the genetic basis of obstructive sleep apnea using a genealogical approach.
- Conditions
- Sleep Apnea Syndromes, Lung Diseases, Insulin Resistance
- Trial name
- NCT00083798
- Volunteers
- 2,843 people
- Sponsor
- University of Pennsylvania
Postoperative Atelectasis, Lung Ultrasonography Score
Evaluation of Recruitment Effectiveness in Patients With Obstructive Sleep Apnea Syndrome Using Lung Ultrasound
Patients with obstructive sleep apnea syndrome are at higher risk for respiratory complications after surgery. Oxygen depletion and respiratory distress are common in patients with obstructive sleep apnea syndrome.
- Conditions
- Postoperative Atelectasis, Lung Ultrasonography Score, Recruitment
- Trial name
- NCT07061002
- Testing
- Lung Recruitment Maneuver, Positional Lung Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul University - Cerrahpasa
Sleep Apnea
A Pilot Study of CPAP Adherence Promotion by Peer Buddies With Sleep Apnea
Obstructive sleep apnea (OSA) is a highly prevalent condition in veterans with some estimates as high as 47%. Poor adherence to the primary treatment of OSA -- continuous positive airway pressure (CPAP) therapy - is associated…
- Trial name
- CPAPPs (NCT01164683)
- Testing
- Peer-driven intervention, Usual Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Apnea of Prematurity, Intermittent Hypoxemia
Strap To Reduce Apnea in Preterm Infants: A Randomized Crossover Trial
The goal of this clinical trial is to learn if a chin strap helps reduce low oxygen episodes in premature babies receiving CPAP or NIPPV (breathing support through the nose).
- Conditions
- Apnea of Prematurity, Intermittent Hypoxemia, Bronchopulmonary Dysplasia of Newborn
- Trial name
- STRAP (NCT07895654)
- Testing
- Chinstrap
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Obstructive Sleep Apnea, Transverse Maxillary Deficiency
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Transverse Orthodontic Deficiency in Children
OSAHS (Obstructive Sleep Apnea Hypopnea Syndrome) in children is a frequent respiratory disorder, whose prevalence is estimated at between 1.2 and 5.7%, and which, if left untreated, can cause severe medical complications.
- Trial name
- ASCOT (NCT07086612)
- Testing
- over nigtht ventilatory polysomnograph test
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sleep Apnea, Obstructive
Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep
This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is…
- Trial name
- Nasal vs Oral (NCT06789770)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
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