Clinical trials: Appendiceal Neoplasm
Small Bowel Cancer, Colorectal Cancer
Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)
This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective.
- Conditions
- Small Bowel Cancer, Colorectal Cancer, Appendiceal Cancer, Biliary Cancer
- Trial name
- LIVELONG (NCT06101277)
- Testing
- Ablative local therapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Davis
Peritoneal Carcinomatosis, Colorectal Cancer
HIPEC for Peritoneal Carcinomatosis
This is a clinical study investigating the new treatment of surgery combined with intraperitoneal mitomycin-C for patients with gastrointestinal cancer that has spread to the peritoneal (abdominal cavity) surface.
- Conditions
- Peritoneal Carcinomatosis, Colorectal Cancer, Appendiceal Cancer, Peritoneal Mesothelioma
- Trial name
- NCT02040142
- Testing
- HIPEC, Mitomycin C
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Albert Einstein College of Medicine
Pseudomyxoma Peritonei, Appendiceal Neoplasms
Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin
The purpose of this study is to determine the impact of antibiotic therapy on the disease progression and overall survival of patients with Pseudomyxoma Peritonei (PMP).
- Trial name
- NCT02387203
- Testing
- PrevPac (Prevacid, Amoxicillin, Clarithromycin)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mercy Medical Center
Colorectal Cancer, Appendiceal Cancer
Intraperitoneal Oxaliplatin in Combo w IV mFOLFIRI for Peritoneal Carcinomatosis From Colorectal & Appendiceal Cancer
This study is a prospective, multi-center, open-label phase I trial designed to determine the maximun tolerated dose of IP oxaliplatin when given in combination with mFOLFIRI.
- Conditions
- Colorectal Cancer, Appendiceal Cancer, Peritoneal Carcinoma
- Trial name
- IPOX-FOLFIRI (NCT04158349)
- Testing
- Oxaliplatin, mFOLFIRI
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Appendix Abscess, Appendicitis
The Prevalence of Appendiceal Tumours in Periappendicular Abscess
Complicated and uncomplicated appendicitis follow different epidemiological trends also suggesting different pathophysiology behind these two different forms of appendicitis.
- Conditions
- Appendix Abscess, Appendicitis, Appendix Mass, Appendix Cancer
- Trial name
- PeriAPPAC-T (NCT04634448)
- Testing
- Interval appendectomy, Follow-up MRI at 1 year
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pseudomyxoma Peritonei, Appendiceal Neoplasm
Gastrointestinal Microbiome Study of Appendiceal Cancer
This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
- Conditions
- Pseudomyxoma Peritonei, Appendiceal Neoplasm, Cancer, Appendiceal
- Trial name
- NCT02599116
- Testing
- Bio-specimen collection, Questionnaire
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mercy Medical Center
Peritoneum Cancer, Peritoneum Neoplasm
International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)
Multicentric, international, web-based prospective documentation of the indications and results of Pressurized Aerosol Chemotherapy (so-called PIPAC or PITAC) for treating malignant pleural and peritoneal diseases.
- Conditions
- Peritoneum Cancer, Peritoneum Neoplasm, Pleural Cancer, Pleural Effusion
- Trial name
- PIPACRegis (NCT03210298)
- Testing
- PIPAC
- Where
- 16 sites in Argentina, Australia and 11 more
- Volunteers
- 1,000 people
- Sponsor
- Sabine Rhode
Carcinoma of the Appendix, Colorectal Cancer
Thalidomide in Treating Patients Who Have Undergone Surgery and Chemotherapy for Cancer That Has Spread Throughout the Abdomen Due to Colorectal Cancer or Appendix Cancer
RATIONALE: Thalidomide may stop the growth of tumor cells by blocking blood flow to the tumor. Giving thalidomide after surgery and chemotherapy may kill any remaining tumor cells.
- Trial name
- NCT00310076
- Testing
- thalidomide, surgery
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Peritoneal Carcinomatosis, Appendiceal Neoplasms
Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC)
The goal of this prospective phase II unicentric Canadian clinical trial is to clarify the feasibility of modified early post-operative intraperitoneal chemotherapy (mEPIC) following cytoreductive surgery (CRS) and hyperthermic…
- Conditions
- Peritoneal Carcinomatosis, Appendiceal Neoplasms, Colorectal Cancer Metastatic
- Trial name
- NCT05913674
- Testing
- Modified early post-operative intraperitoneal chemotherapy (mEPIC)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cancer
Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer
RATIONALE: Hepatic arterial infusion uses a catheter to deliver anticancer substances directly into the liver. Drugs used in chemotherapy, such as melphalan, work in different ways to stop tumor cells from dividing so they stop…
- Trial name
- NCT00096083
- Testing
- isolated perfusion, melphalan
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Delcath Systems Inc.
Carcinoma of the Appendix, Primary Peritoneal Cavity Cancer
Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix
This randomized phase II trial is studying the side effects and how well giving oxaliplatin or mitomycin C directly into the abdomen after surgery works in treating patients with tumors of the appendix.
- Trial name
- NCT01580410
- Testing
- mitomycin C, oxaliplatin, therapeutic conventional surgery
- Where
- 3 sites in United States
- Volunteers
- 136 people
- Sponsor
- Wake Forest University Health Sciences
Appendix Cancer
LCI-GI-APX-NIN-001: Nintedanib in Metastatic Appendiceal Carcinoma
The purpose of this trial is to evaluate the disease control rate of nintedanib in subjects with metastatic appendiceal cancer for whom initial fluoropyrimidine-based chemotherapy has failed.
- Trial name
- NCT03287947
- Testing
- nintedanib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Anal Cancer, Colorectal Cancer
Interleukin-12 in Treating Patients With Cancer in the Abdomen
RATIONALE: Interleukin-12 may kill tumor cells by stimulating a person's white blood cells to kill cancer cells. PURPOSE: Phase I trial to study the effectiveness of interleukin-12 in treating patients with cancer in the abdomen.
- Conditions
- Anal Cancer, Colorectal Cancer, Gallbladder Cancer, Gastric Cancer
- Trial name
- NCT00003046
- Testing
- Recombinant Interleukin-12
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Appendiceal Mucinous Neoplasm, Pseudomyxoma Peritonei
Metformin in Pseudomyxoma Peritonei Secondary to Appendiceal Mucinous Neoplasms
This is a pilot, open-label clinical trial determining the feasibility of metformin therapy in subjects with pseudomyxoma peritonei (PMP) secondary to appendiceal mucinous neoplasms (AMNs).
- Trial name
- NCT07693452
- Testing
- Metformin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Irvine
Cancer
Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005860
- Testing
- floxuridine, leucovorin calcium, oxaliplatin
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer
RATIONALE: PV701 may be able to kill tumor cells while leaving normal cells undamaged. PURPOSE: Phase I trial to study the effectiveness of PV701 in treating patients who have advanced or recurrent ovarian epithelial, fallopian…
- Trial name
- NCT00055705
- Testing
- PV701
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Pancreas Cancer
CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab
This is a phase IB/IIA trial to ensure the safety of Certepetide (LSTA1/CEND-1) in combination with with Folfirinox with or without Panitumumab for treatment of pancreatic, colon and appendiceal cancers
- Conditions
- Colon Cancer, Pancreas Cancer, Digestive Cancer
- Trial name
- CENDIFOX (NCT05121038)
- Testing
- CEND-1, Panitumumab, Folfirinox
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Anup Kasi
Cancer
Thalidomide and Docetaxel in Treating Patients With Advanced Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00049296
- Testing
- docetaxel, thalidomide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Appendiceal Cancer
Molecular Characterisation of Appendiceal Cancer
Patients ≥ 18 years old who have been diagnosed with appendiceal cancer with peritoneal metastases, have had cytoreductive surgery, have availability of archival tumour tissue and have consented to our institutional biobank…
- Trial name
- NCT05364788
- Testing
- Retrospective tissue sample analysis
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Christie NHS Foundation Trust
Carcinoma of the Appendix, Colorectal Cancer
Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Carcinoma of the Appendix, Colorectal Cancer, Small Intestine Cancer
- Trial name
- NCT00019773
- Testing
- capecitabine, oxaliplatin
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)