Clinical trials: Appendicitis, Surgery
Perforated Appendicitis
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix.
- Trial name
- PAPA Pilot (NCT07656636)
- Testing
- Postoperative antibiotico-prophylaxis, No postoperative antibiotics
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Appendicitis, Cholelithiasis
Minimally Invasive Surgery: Using Natural Orfices
This is an observational study of pain and outcomes from females undergoing transvaginal NOTES removal of their appendix or gallbladder.
- Conditions
- Appendicitis, Cholelithiasis, Gallstones
- Trial name
- NOTES (NCT00530998)
- Testing
- Transvaginal Appendectomy, Transvaginal Cholecystectomy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Acute Appendicitis Without Peritonitis
Antibiotics Versus Surgery in Acute Appendicitis
The acute appendicitis (AA) is a very common disease with a life time risk 7-8% and the highest incidence in the second decades .
- Trial name
- ASAA (NCT01421901)
- Testing
- Ertapenem, appendectomy
- Where
- Italy
- Volunteers
- 218 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Appendicitis, Surgery
The Effect of Kinesio Taping in Pediatric Surgery
This study was planned to determine the effect of kinesio taping (KT) applied to the abdominal area after surgery on pain and gas output in children aged 6-12 years who had open appendicitis surgery.
- Conditions
- Appendicitis, Surgery, Pain, Acute
- Trial name
- NCT06344897
- Testing
- Kinesio taping
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- KTO Karatay University
Perforated Appendicitis
Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution
This study is to evaluate the effectiveness of peritoneal lavage with super-oxidised solution in reducing surgical site infection after open surgery for perforated appendicitis.
- Trial name
- PLaSSo (NCT04512196)
- Testing
- Superoxidized Water, Normal Saline
- Where
- Malaysia
- Volunteers
- 102 people
- Sponsor
- Hospital Queen Elizabeth, Malaysia
Acute Appendicitis
A Trial on Laparoscopic Appendectomy Versus Single Port Appendectomy
The aim of this study is to compare patients who undergone single-port access laparoscopic appendectomy to those who underwent conventional three-port laparoscopic appendectomy (TPLA) in a prospective randomized trial
- Trial name
- NCT01348464
- Testing
- single port appendectomy, three port appendectomy
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Gachon University Gil Medical Center
Appendicitis (Diagnosis)
Evaluating the Outcome of Surgical Clip Versus Ligatures in Securing Base of Appendix in Laparoscopic Appendicectomy.
The goal of this clinical trial is to evaluate the outcome of using surgical clip versus ligature to secure the base of appendix during laparoscopic appendicectomy.
- Trial name
- OSCVL (NCT07689123)
- Testing
- single polymeric clip (XXL Click'aV Plus, Grena), suture ligature
- Where
- Malaysia
- Volunteers
- 64 people
- Sponsor
- Universiti Sains Malaysia
Ruptured Appendicitis
Early Versus Interval Appendectomy for Ruptured Appendicitis in Children
The purpose of this randomized trial is to compare two commonly utilized surgical treatments for children with ruptured appendicitis: early appendectomy, versus interval appendectomy.
- Trial name
- RAPTOR (NCT00435032)
- Testing
- early appendectomy, interval appendectomy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Tennessee
Complicated Appendicitis
Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.
The PIPA trial is a prospective, multicentre, cluster randomized cluster crossover non-inferiority study. We aim to test whether a three-day postoperative course of per oral antibiotics is non-inferior to a three-day…
- Trial name
- PIPA (NCT04803422)
- Testing
- Antibiotic
- Where
- 2 sites in Denmark
- Volunteers
- 3,193 people
- Sponsor
- Zealand University Hospital
Appendicitis, Surgery
Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience
Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low.
- Trial name
- NCT07291882
- Testing
- Appendectomy
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Minia University
Pediatric Hernia, Laparoscopic Surgery
Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery
a prospective, double-blind, fully randomized controlled, non-inferiority clinical trial to investigate the use of total intravenous anesthesia in pediatric laparoscopic surgery.
- Conditions
- Pediatric Hernia, Laparoscopic Surgery, Appendicitis, Surgery
- Trial name
- NCT06735430
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tongji Hospital
Pain
Which Trocar Access Site Should We Use in Laparoscopic Appendectomy?
Open appendectomy has been used in the treatment of appendicitis, which is among the most common emergency pathologies worldwide, since the end of the 19th century.
- Trial name
- NCT05311995
- Testing
- Only different trocar sites
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Inonu University
Appendectomy, Laparoscopic, Acute Appendicitis
Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy
Acute appendicitis is the most common surgical emergency in children. Despite the widespread adoption of laparoscopic appendectomy, postoperative care still varies widely between institutions, with prolonged fasting, opioid-based…
- Conditions
- Appendectomy, Laparoscopic, Acute Appendicitis, Pediatric Surgery, ERAS
- Trial name
- NCT07643285
- Testing
- Comprehensive 20-Item Pediatric ERAS Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ahmet Burak Doğan, MD
Abdominal Adhesions
Clinical Study of the Effectiveness, Tolerability and Safety of the Drug "Anti-spike, Gel, 100 g in Bottles in Package No. 1" Produced by the Republican Unitary Enterprise "Unitekhprom BSU", With a Single Intraperitoneal Use After Surgery in Adult Patients With Acute Phlegmonous Appendicitis
The purpose of the clinical trials is the evaluation of the effectiveness and safety of a single intraperitoneal use of the drug "Antispike, gel, 100 g in a bottle" produced by Unitary Enterprise Unitehprom BSU, Belarus in…
- Trial name
- OLTOSPAN-02 (NCT06365632)
- Testing
- Antispike gel, 100 g in a flask, produced by UNITEHPROM BSU, Republic of Belarus, antegrade appendectomy
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- Research Institute for Physical Chemical Problems of the Belarusian State University
ERAS, Pediatric Disorder
Studding the Implementation of ERAS Protocols in Pediatric Surgery
this is a retrospective cohort, descriptive study, investigating the role of ERAS protocols, in pediatric surgery and evaluate the feasibility and effectiveness of implementing these protocols
- Conditions
- ERAS, Pediatric Disorder, Appendicitis, Hydrocele
- Trial name
- NCT04870242
- Testing
- Observational study, non-interventional
- Where
- Jordan
- Volunteers
- 178 people
- Sponsor
- University of Jordan
Appendicitis, Surgical Site Infection
Transumbilical Laparoscopic Appendectomy
Transumbilical laparoscopic appendectomy (TULA) is increasingly favored in the treatment of appendicitis within the realm of minimally invasive surgical approaches.
- Trial name
- NCT06177418
- Testing
- Transumbilical laparoscopic appendectomy + Glove finger technique, Standard transumbilical laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Necmi Kadıoğlu Hospital
Appendicitis
A Comparison of Appendicectomy Outcomes in Children Between Paediatric and General Surgical Centres in Scotland
Introduction Appendicectomy (or appendectomy in US usage) is the single most commonly performed emergency surgical operation performed on British children.
- Trial name
- NCT02047786
- Where
- United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- University of Edinburgh
Cholecystolithiasis, Cholecystitis
Influence of Hospital Volume on Mortality and Short-term Postoperative Outcomes in Uncomplex General Surgery in Switzerland
The effect of centralisation measures on the operative outcomes after any type of surgery in Switzerland has not been highlighted yet.
- Conditions
- Cholecystolithiasis, Cholecystitis, Inguinal Hernia, Femoral Hernia
- Trial name
- NCT07022665
- Testing
- Appendicectomy, Cholecystectomy, Umbilical hernia repair
- Where
- Switzerland
- Volunteers
- 399,701 people
- Sponsor
- Cantonal Hospital of St. Gallen
Gastroschisis, Anorectal Malformation
Children's Surgery in Sub-Saharan Africa
Background: Five billion people worldwide do not have access to safe, affordable surgical care. A significant proportion live in sub-Saharan Africa (SSA), where up to 50% of the population are children.
- Conditions
- Gastroschisis, Anorectal Malformation, Appendicitis, Intussusception
- Trial name
- PaedSurgAfrica (NCT03185637)
- Testing
- Various interventions for each of the conditions.
- Where
- United Kingdom
- Volunteers
- 1,407 people
- Sponsor
- King's College London
Laparoscopic Surgery for Appendicitis, Laparoscopic Surgery for Cholecystitis
Pain Post Abdominal Laparoscopy Prevention With Arcoxia
To test the analgesic efficacy of etoricoxib used before a surgical procedure compared to the already known effect when administered after such a procedure.
- Conditions
- Laparoscopic Surgery for Appendicitis, Laparoscopic Surgery for Cholecystitis, Laparoscopic Surgery for Ovarian Cysts
- Trial name
- NCT00565682
- Testing
- etoricoxib 120 mg
- Volunteers
- 60 people
- Sponsor
- Hospital Vozandez