Clinical trials: Appendicitis
Appendicitis
Single-incision Laparoscopic (SILS) Versus Conventional Laparoscopic Appendectomy for the Treatment of Acute Appendicitis
Recent advances in laparoscopic instrumentation have made it possible to perform intra-abdominal operations entirely through a small incision that can be hidden within the umbilicus.
- Trial name
- NCT00997516
- Testing
- SILS appendectomy, conventional laparoscopic appendectomy
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Francisco
Appendicitis Perforated
Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA)
This study is an internal pilot for a multicenter, blinded randomized controlled trial. The purpose of the multicenter trial is to determine whether post-operative piperacillin/tazobactam is more effective than ceftriaxone and…
- Trial name
- ALPACA (NCT05943223)
- Testing
- Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McMaster Children's Hospital
Appendicitis
Is Interval Appendectomy Necessary?
Appendicitis is one of the most common surgical problems in children, with 20-35% of patients having perforated by the time they present to a doctor. In these cases, the patient is often treated non-surgically with antibiotics.
- Trial name
- NCT01853683
- Testing
- Conservative Management, Operative Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Children's Hospital of Eastern Ontario
Appendicitis, Cholecystitis
NOVOsyn® for Trocar Incision After Laparoscopic Appendectomy and Cholecystectomy
The aim of this study is to evaluate if the application of a Chlorhexidine coated suture (Novosyn® CHD) will reduce the colonization of bacteria in comparison to an uncoated suture (Novosyn®) used for the closure of trocar wounds…
- Trial name
- NOVOTILAC (NCT04033211)
- Testing
- Novosyn® CHD for fascia and skin closure, Novosyn® for fascia and skin closure
- Where
- 4 sites in Germany, Spain
- Volunteers
- 316 people
- Sponsor
- Aesculap AG
Acute Appendicitis
Feasibility of Outpatient Appendectomy for Acute Appendicitis
The aim of our monocentric prospective in intention-to-treat study is to evaluate the feasibility of outpatient appendectomy for non complicated acute appendicitis.
- Trial name
- APPENDAMBU (NCT01839435)
- Testing
- outpatient surgery
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Appendicitis
Inflammatory Parameters as Predictive Factors for Complicated Appendicitis
Acute appendicitis is a major cause of acute abdomen. Although its diagnosis is clinical, it is often supported by complementary diagnostic tests.
- Trial name
- NCT05116124
- Testing
- dosing of inflammatory parameters
- Volunteers
- 841 people
- Sponsor
- Centro Hospitalar do Tâmega e Sousa
Appendicitis
The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults
Accurate diagnostic biomarkers for acute appendicitis (AA) are lacking. Circulating fibrocytes (CFs) are increased in inflammatory states. It is not known whether they are altered in appendicitis.
- Trial name
- NCT03988660
- Testing
- Circulating fibrocytes
- Where
- Ireland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital of Limerick
Diagnosis of Acute Appendicitis in Children
Urinary 5-HIAA for Diagnosis of Acute Appendicitis in Children, Does it Help?
it is randomized control study. two groups of children (n=191) were divided into two groups A and B. Group A included children subjected to the classical protocol of diagnosis of acute appendicitis.
- Trial name
- NCT04527263
- Testing
- measurement of urinary 5-HIAA
- Where
- Egypt
- Volunteers
- 191 people
- Sponsor
- Tanta University
Acute Uncomplicated Appendicitis
Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children
The majority of children with uncomplicated acute appendicitis may be considered for either a non-operative or an operative management.
- Trial name
- NACAC (NCT07587450)
- Testing
- Amoxi Clavulanate, appendicectomy
- Where
- 10 sites in France
- Volunteers
- 724 people
- Sponsor
- University Hospital, Toulouse
Appendicitis
Restricted or Liberal Antibiotics After Appendectomy - Denver Health
The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.
- Trial name
- CASARELAX (NCT05002829)
- Testing
- Restricted Duration of SOC Antibiotic Use, Liberal Duration of SOC Antibiotic Use
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- Denver Health and Hospital Authority
Gallstones, Appendicitis
Hybrid Transvaginal-Transabdominal Endoscopic Surgery
The is a pilot study to evaluate the safety and efficacy of hybrid transvaginal-transabdominal procedures. Diagnostic peritoneoscopy (visualizing the inside of the abdomen), appendectomy (removal of the appendix), and…
- Conditions
- Gallstones, Appendicitis, Pelvic Pain
- Trial name
- NCT01039129
- Testing
- Endoscopic Cholecystectomy, Endoscopic Appendectomy, Endoscopic Peritoneoscopy
- Where
- United States
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Complicated Appendicitis
Causes of Complicated Appendicitis at Referral Hospital
The study was conducted on a medical record of previously treated patients for acute appendicitis at HFSUH, Harar, Ethiopia. The study design was case-control with a total sample size of 402.
- Trial name
- AA (NCT05005104)
- Where
- Ethiopia
- Volunteers
- 402 people
- Sponsor
- Haramaya Unversity
Appendicitis Acute, Appendicitis
Clinical Trial for a Outpatient Clinical Management of Urgent Laparoscopic Appendectomy
The aim of this study is to evaluate the safety and efficacy of outpatient management of uncomplicated acute appendicitis. For this purpose, a randomized clinical trial was designed.
- Trial name
- ASI (NCT05401188)
- Testing
- Outpatient, hospitalization
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- HJ23
Acute Appendicitis
Complement Diagnosis of Acute Appendicitis
Acute appendicitis is a common condition requiring urgent surgery but is often difficult to distinguish from other non-surgical conditions such as urinary infections, pelvic inflammatory disease and non-specific abdominal pain.
- Trial name
- CDAA (NCT03450642)
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Exeter
Acute Appendicitis
Comparing Proposed Algorithm and Current Practice in the Evaluation of Suspected Appendicitis
Acute appendicitis is one of the most common causes of acute abdominal pain requiring surgical intervention. In the current era, with diagnostic imaging technique like Computed Tomography (CT), negative appendectomy rates have…
- Trial name
- RCTAppAlg (NCT03324165)
- Testing
- Proposed Algorithm
- Where
- 2 sites in Singapore
- Volunteers
- 160 people
- Sponsor
- Singapore General Hospital
Appendicitis
Magnetic Resonance Imaging (MRI) of Appendicitis in Children
Study to find out if MRI can diagnose appendicitis in children as well as or better than CT scan and/or ultrasound scan performed at the same time. No additional contrast material or sedation will be used to perform the MRI.
- Trial name
- NCT00723788
- Testing
- MRI of the abdomen
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's National Research Institute
Acute Appendicitis
Variation in Acute Appendicitis During COVID-19 Pandemic in Italy
retrospective observational study of variation in incidence and clinical presentation of appendicitis during the pandemic in northern Italy, compared with the same period in the previous 2 years.
- Trial name
- NCT04649996
- Testing
- Appendectomy
- Where
- 6 sites in Italy
- Volunteers
- 532 people
- Sponsor
- University of Milano Bicocca
Laparoscopic Appendectomy
Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic Appendectomy
Laparoscopic appendectomy is the standard procedure for acute appendicitis. Among the various steps of the procedure one of the rate limiting step is the ligation of the appendicular stump which can be done using suture material…
- Trial name
- NCT07129746
- Testing
- Metallic clip ligation of the appendicular stump, Suture ligation of appendicular stump
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Jinnah Hospital
Preoperative Anxiety, Children
Effects of Cartoons and Mobile Games on Preoperative Anxiety and Fear in Children With Appendicitis: An RCT
his study aims to evaluate the effects of cartoon viewing and mobile game playing on preoperative anxiety and fear levels in children aged 7-12 years who are hospitalized for appendicitis surgery.
- Conditions
- Preoperative Anxiety, Children, Appendicitis (Diagnosis), Fear
- Trial name
- NCT07640230
- Testing
- Cartoon-Assisted Distraction (Şüko Ameliyat Oluyor), Mobile Game
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Ankara City Hospital Bilkent
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University