Clinical trials: Appendicitis (Diagnosis)
Appendicitis Perforated
Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis
The objective of this trial is to evaluate if intraoperative intraperitoneal administration of fosfomycin, metronidazole and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) followed by oral…
- Trial name
- NCT03435900
- Testing
- Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o., Standard antibiotics intravenously
- Where
- 2 sites in Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Acute Appendicitis
Antibiotics vs Surgery in Acute Appendicitis
The aim of this study is to identify clinical, laboratory, and imaging parameters that can predict the most appropriate treatment strategy in patients diagnosed with acute appendicitis.
- Trial name
- NCT07492329
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Antibiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sebahattin Celik MD
Acute Appendicitis
Changes in the Treatment of Acute Appendicitis
The purpose of this study was to analyse the epidemiology, diagnostics, the type of surgical techniques and their development over time, and mortality in acute appendicitis in 68 hospitals in Germany based on routine data between…
- Trial name
- TreatApp (NCT06558760)
- Volunteers
- 31,988 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Appendicitis
Comparative Study of Microwave Radiometry and Ultrasonography for the Diagnosis of Acute Appendicitis
This study will evaluate the use of microwave radiometry in a population of patients diagnosed with acute appendicitis and treated with appendectomy.
- Trial name
- NCT02108340
- Testing
- Microwave radiometry
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Hippocration General Hospital
Gallbladder Diseases, Appendicitis
NOTES Transvaginal Cholecystectomy and Appendectomy
Natural Orifice Translumenal Endoscopic Surgery (NOTES) is considered by many leading expert surgeons to be the next step in MIS (Minimally Invasive Surgery).
- Trial name
- NCT00552162
- Testing
- NOTES Transvaginal Cholecystectomy, NOTES Transvaginal Appendectomy
- Where
- 2 sites in Israel
- Volunteers
- 6 people
- Sponsor
- Hadassah Medical Organization
Pain, Appendicitis
PAINED: Project Addressing INequities in the Emergency Department
Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes.
- Conditions
- Pain, Appendicitis, Bias, Racial, Fractures, Bone
- Trial name
- PAINED (NCT05488080)
- Testing
- Department-level audit and feedback and electronic health record-embedded clinical decision support
- Where
- United States
- Volunteers
- 22,032 people
- Sponsor
- Children's National Research Institute
Appendicitis
Improvement of Appendix Identification and Appendicitis Diagnosis in us After Administration of Oral Contrast Medium
Rate of appendix localization on ultrasound is not high. We suggest a way to improve it's localization by oral administration of iodinated contrast material.
- Trial name
- us (NCT02194140)
- Testing
- oral iodinated contrast material
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Appendicitis
Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children
OBJECTIVE The aim of this study is to compare the effectiveness of initial non-operative treatment strategy (reserving appendectomy for those not responding or with recurrent disease) with immediate appendectomy in children from…
- Trial name
- APAC (NCT02848820)
- Testing
- Augmentin + Gentamicin, Appendectomy
- Where
- 15 sites in Netherlands
- Volunteers
- 302 people
- Sponsor
- Ramon Gorter
Ambulatory Surgery, Laparoscopy
Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit.
- Conditions
- Ambulatory Surgery, Laparoscopy, Shoulder Impingement Syndrome, Ovarian Cysts
- Trial name
- Herko (NCT04142203)
- Testing
- 23 h surgery
- Where
- Finland
- Volunteers
- 993 people
- Sponsor
- Kuopio University Hospital
Appendicitis Acute
Polymerase Chain Reaction (PCR) and Cultivation of the Peritoneal Fluid at Operation for Appendicitis and Postoperative Enteral Antibiotic Treatment
Patients diagnosed with acute appendicitis receives antibiotics during the operation, and only patients where the surgeon suspects a complicated appendicitis with spread inflammation to the abdominal cavity receive antibiotics…
- Trial name
- PACPAT (NCT04713527)
- Testing
- Cultivation and PCR within 24 hours, Enteral antibiotics
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Southern Denmark
Appendicitis, Chronic Post-Procedural Pain
Pain and Discomfort After Appendectomy in Children
Appendectomy is the most common surgical procedure. Chronic abdominal pain is an uncommon complication following appendectomy. It is observed that pediatric patients who have undergone abdominal surgical procedure complained of…
- Trial name
- NCT03791229
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sakarya University
Appendicitis
APPEndicitis and Laparoscopic Criteria; APPEL Study
A diagnostic laparoscopy is frequently used to confirm the diagnosis of appendicitis. However, laparoscopic criteria for determining appendicitis are not defined.
- Trial name
- APPEL (NCT01054417)
- Where
- Netherlands
- Volunteers
- 142 people
- Sponsor
- University Medical Center Groningen
Appendicitis, Pain, Postoperative
Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy
There is concern that pain prescription after outpatient pediatric surgical procedures is excessive and is in excess of patient need.
- Trial name
- NCT03528343
- Testing
- Non-narcotic pain control
- Where
- United States
- Sponsor
- University of Utah
Appendicitis, Appendectomy
Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?
Type: prospective observational multicenter trial. Population of interest: adult patients undergoing laparoscopic appendectomy for acute appendicitis.
- Trial name
- RESIDENT1 (NCT05075252)
- Testing
- laparoscopic lavage
- Where
- Italy
- Volunteers
- 1,067 people
- Sponsor
- Niguarda Hospital
Abdominal Pain, Appendicitis
Ketorolac for Moderate to Severe Abdominal Pain in Children
In children and adolescents (older than 6 years in age) who arrive in the pediatric emergency department because they have been having 5 days or less of abdominal pain (possible appendicitis), will patients who are treated with…
- Conditions
- Abdominal Pain, Appendicitis, Analgesia, Child, Only
- Trial name
- KETO-APP (NCT04528563)
- Testing
- Ketorolac Tromethamine 10 MG/ML, Morphine Sulfate 10Mg/1mL Injection
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Hamilton Health Sciences Corporation
Appendicitis
Appendicectomy Skin Closure Technique: Changing Paradigms (ASC)
To compare the results associated with two different skin closure techniques in open appendectomy. 200 patients were included after acute appendicitis diagnosis in emergency department.
- Trial name
- ASC (NCT02625987)
- Testing
- Continuous intradermic stitch, Separated stitches
- Volunteers
- 200 people
- Sponsor
- María Valeria Jiménez Baez
Acute Appendicitis
Comparative Study on the Diagnostic Validity of the Alvarado Score, Appendicitis Inflammatory Response (AIR), and Adult Appendicitis Score (AAS) in Acute Appendicitis at East Lancashire Hospitals NHS Trust (ELHT)
This retrospective observational study aims to compare the diagnostic accuracy of Alvarado Score, Appendicitis Inflammatory Response (AIR) Score, and Adult Appendicitis Score (AAS) in predicting histologically confirmed acute…
- Trial name
- DV-AAA ELHT (NCT07804238)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Gangrenous Appendicitis
Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis
A prospective, randomized controlled clinical trial was conducted at the Hospital Universitario de Santander to test the effectiveness of providing a single 1-dose therapy of antibiotic prophylaxis versus a 5-day antibiotic…
- Trial name
- NCT01115153
- Testing
- prophylaxis, therapy
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Universidad Industrial de Santander
Appendicitis
Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon
The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.
- Trial name
- NCT04168866
- Testing
- Operative management, Drainage or antibiotics
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Yale University
Acute Appendicitis
Optimizing the Diagnosis of Acute Appendicitis
Aim of the study: to identify the signs of acute appendicitis delta signs - clinical, laboratory or ultrasound signs, whose change (delta) would allow to identify or deny the diagnosis of acute appendicitis without a computed…
- Trial name
- OPTIMA (NCT04117061)
- Testing
- Observation
- Where
- Lithuania
- Volunteers
- 200 people
- Sponsor
- Vilnius University