Clinical trials: Approach-Approach Conflict, open to volunteers
Bladder Cancer
TReatment Approaches and bIomarkers preValence in bladdEr Cancer in RuSsian Federation
A multicentre observational study on treatment approaches and HER2 positive status prevalence in different stages of bladder cancer and PD-L1-positive status in metastatic bladder cancer in Russian Federation
- Trial name
- RIVERS (NCT07038928)
- Where
- 20 sites in Russia
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Lumbar Spondylosis
Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves
The purpose of this voluntary research study is to determine whether the parasagittal approach to lumbar medial branch (LMB) nerve radio frequency ablation (RFA) will have greater efficacy than the traditional approach to lumbar…
- Trial name
- LMB-RFA (NCT06283628)
- Testing
- Radiofrequency ablation of lumbar medial branch nerves.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Milton S. Hershey Medical Center
Prostate Cancer
Comparing Two Different Boost Approaches in Radiation Therapy for People With Prostate Cancer
In this study the investigators will find out whether the use of a new type of boost approach called irreversible electroporation (IRE) is as effective as the standard boost approach of radiation therapy for participants with…
- Trial name
- NCT07548164
- Testing
- NanoKnife System, Stereotactic Body Radiation Therapy
- Where
- 8 sites in United States
- Volunteers
- 224 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Transgender, Gut Microbiome
Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach
The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors.
- Conditions
- Transgender, Gut Microbiome, Immune System, Cardiovascular Risk Factors
- Trial name
- XCVD (NCT05334888)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Retention
Restoration of Non-carious Cervical Lesions With Different Resin Composites and Universal Adhesive
patients with non carious cervical lesions suffer from dentin sensitivity and presence of cavitations and gingival recession. Restoring these lesions with different composites and evaluation of restorations every 6 months will be…
- Trial name
- NCT06393699
- Testing
- composite restoration
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Variation of Keratinized Mucosa After Implant Surgery
Keratized Mucosa in CG Implant Placement: CTG vs Flapless
The present study will evaluate the difference in terms of keratinazed mucosa (KM) in computer guided implant placement with immediate loading, comparing a flapless approach to flap surgery with connective tissue graft.
- Trial name
- NCT05073952
- Testing
- Connective tissue graft, Flapless
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Milan
General Anesthesia, Cervical Plexus Block
EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY
The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and…
- Conditions
- General Anesthesia, Cervical Plexus Block, Thyroid Surgery
- Trial name
- NCT07592832
- Testing
- General Anesthesia, cervical plexus block
- Volunteers
- 60 people
- Sponsor
- Harran University
Ischemic Stroke, TIA
Determining the MCID for the TOPICS-SF and PROMIS-10 in Older Patients That Suffered an Ischemic Stroke or TIA
Patient-related outcome measures (PROMs) play a crucial role in assessing patient outcomes in healthcare. Two of these PROMs are the The Older Persons and Informal Caregivers Survey Short Form (TOPICS-SF) and Patient-Reported…
- Trial name
- CONSIDER (NCT06495073)
- Testing
- PROMIS-10 and TOPICS-SF
- Where
- 2 sites in Netherlands
- Volunteers
- 125 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Risk of Breast Cancer, Risk of Gynaecological Cancer
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals
LEAH is a prospective, observational, single-centre, non-randomised, open-label study of people at increased risk of cancer or malignant disease.
- Conditions
- Risk of Breast Cancer, Risk of Gynaecological Cancer, Risk of Colorectal Cancer, Risk of Upper Gastrointestinal Cancers
- Trial name
- LEAH (NCT06907095)
- Testing
- biological samples
- Where
- France
- Volunteers
- 5,909 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Total Knee Anthroplasty
Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches
This is a single-institution, prospective, randomized study comparing the medial parapatellar and subvastus approaches in primary total knee arthroplasty using continuous, implant-based gait monitoring.
- Trial name
- NCT07348835
- Testing
- Total Knee Arthroplasty Medial Parapatellar Approach, Total Knee Arthroplasty Subvastus Approach
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Total Joint Specialists
Turner Syndrome
A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases
Turner syndrome is a condition in which a girl's body does not make enough estrogen on its own, so doctors give estrogen to help start breast and uterine (womb) development.
- Trial name
- TRIFECTA-DARED (NCT07041814)
- Testing
- Oral estradiol valerate, Transdermal 17β estradiol
- Where
- Malaysia
- Volunteers
- 24 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Oral Squamous Cell Carcinoma (OSCC)
Study Comparing Different Neck Treatment Approaches in Patients With Oral Cancer Without Visible Neck Spread
The goal of this clinical trial is to learn whether selective neck dissection involving lymph node levels I-III is as effective as selective neck dissection involving levels I-IV in treating adults with clinically node-negative…
- Trial name
- ExtentN0 (NCT07726199)
- Testing
- Selective Neck Dissection (Levels I-IV), Intervention : Selective Neck Dissection (Levels I-III)
- Where
- India
- Volunteers
- 267 people
- Sponsor
- Kolhapur Cancer Centre - Cancer Centers of America
Siewert Type II Adenocarcinoma of Esophagogastric Junction
Comparison of Different Operations for Siewert Type II Adenocarcinoma of Esophagogastric Junction
The incidence of esophagogastric junction has been increasing in recent years, and surgery is an important method for the treatment of adenoma at the esophagogastric junction.
- Trial name
- NCT05356520
- Testing
- Endoscopy Ivor-lewis, Laparoscopic transabdominal enlarged gastrectomy
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Adolescence Idiopathic Scoliosis, Core Stabilization Exercise
Effect of Core Stabilization Exercises Versus Traditional Rehabilitation in Adolescent With Idiopathic Scoliosis
This study aims to compare the effectiveness of core stabilization exercises versus traditional rehabilitation exercises in adolescents with idiopathic scoliosis.
- Conditions
- Adolescence Idiopathic Scoliosis, Core Stabilization Exercise, Traditional Rehabilitation, Adolescents
- Trial name
- AIS (NCT07363226)
- Testing
- Core stabilization Exercises program, Traditional Rehabilitation exercises program
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Armed Forces Hospitals, Southern Region, Saudi Arabia
Time
Perioperative Analgesic Effect of Different Volumes of Modified Thoracoabdominal Perichondrial Approach on Patients Undergoing Sleeve Gastrectomy: Prospective Randomized Trial
Sleeve gastrectomy is a leading technique in metabolic \& bariatric surgery. It gained ever-increasing popularity among laparoscopic bariatric surgeries and has proved to be a successful method in achieving considerable weight…
- Trial name
- NCT07510347
- Testing
- Modified Thoracoabdominal Nerve Block through perichondrial approach (M-TAPA)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Chronic Non-specific Neck Pain
Effects of Physiotherapy Approaches on Biopsychosocial Outcomes in Chronic Non-Specific Neck Pain
Chronic non-specific neck pain (CNSNP) is a widespread musculoskeletal condition leading to pain, disability, and impaired quality of life.
- Trial name
- NCT07784504
- Testing
- Structured Exercise Program, Sensorimotor Training, Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul Medipol University Hospital
Schistosomiasis, Schistosoma Mansoni
Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis
The goal of this clinical trial is to learn if treating individuals living in Uganda who have liver fibrosis (scarring) due to schistosomiasis would benefit from more frequent treatment with drug praziquantel.
- Conditions
- Schistosomiasis, Schistosoma Mansoni, Liver Fibrosis, Portal Hypertension
- Trial name
- SchiFT (NCT07754617)
- Testing
- Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year
- Where
- Uganda
- Volunteers
- 600 people
- Sponsor
- Rhode Island Hospital
Postoperative Delirium, Postoperative Pain, Acute
Postoperative Delirium and Analgesia in Elderly Patients
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
- Trial name
- NCT07849517
- Testing
- adductor canal block and biFes block including bupivacain, Periarticular infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Frozen Embryo Transfer
Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer
To investigate the levels of Relaxin in different types of endometrial preparation for a frozen embryo transfer cycle. Up to now it is unclear, whether ovulation with a functional corpus luteum (CL) will be present in a natural…
- Trial name
- NCT06526520
- Testing
- Exposure to progesterone or HRT medication
- Where
- United Arab Emirates
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Obesity & Overweight
How the Body Processes Sugar After Eating, in People With Different Body Weights
The goal of this clinical trial is to learn how a high-glycaemic meal affects the way the body processes glucose in healthy adults who are either lean or have obesity.
- Trial name
- NCT07690176
- Testing
- Low-glycemic breakfast (randomized vs high glycemic), High-glycaemic breakfast (randomized vs low glycemic), High-glycaemic breakfast
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wageningen University