Clinical trials: Arginine
Muscular Fatigue
Effect of Chronic Supplementation of L-arginine in the Muscular Performance
The primary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular fatigue of the quadriceps, expressed in terms of the Fatigue Resistance Factor (FRF).
- Trial name
- NCT00785811
- Testing
- L-arginine aspartate (Targifor)
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sanofi
PDAC, Pancreas Adenocarcinoma (MSI-H)
Targeted Nutritional Intervention (HMB, Arginine, Glutamine) in Patients With Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is frequently associated with cancer cachexia, a condition characterized by progressive loss of skeletal muscle mass and strength driven by systemic inflammation.
- Trial name
- NUTRI-MYO (NCT07883161)
- Testing
- HMB / L-Arginine / L-Glutamine oral nutritional mixture, Standard Dietary Counseling
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Spirometry, Qadriceps Muscle
The Effect of Orally Administered L- Arginine on Quadriceps Strenght in Healthy Smokers
The study will investigate changes in certain locomotor parameters as early predictors of disease in smokers who are prone to develop chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04643600
- Testing
- L-Arginine, 500 Mg Oral Capsule
- Where
- Croatia
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Goranka Radmilović
Intrauterine Growth Restriction Asymmetrical
L-arginine in Treatment of Intrauterine Growth Restriction
Intrauterine growth restriction is an important problem in neonatal care. Intrauterine growth restriction (IUGR) is defined as a fetal weight below the 10th percentile for gestational age.
- Trial name
- NCT03321292
- Testing
- L-arginine 1000 mg and Acetylesalicylic acid75mg, acetylsalicylic acid 75 mg
- Where
- Egypt
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypertension in Pregnancy
Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy
The purpose of this study is to evaluate the effects of oral L-Arginine in pregnant women with chronic hypertension.
- Trial name
- NCT00571766
- Testing
- L-Arginine
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Arginine Vasopressin Deficiency, Diabetes Insipidus
Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls
This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched…
- Trial name
- OxyMOTION (NCT06676774)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Blood Pressure
Oral L-Citrulline and ADMA in Pregnancy
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to obese subjects will decrease the plasma ADMA/L-arginine ratio, lower maternal blood pressure, improve…
- Trial name
- NCT00743210
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Absorption of Amino Acids and Peptides
Pharmacokinetic Effect of AstraGin on Arginine Absorption and Nitric Oxide Production in Healthy Subjects
AstraGin increases the absorption of amino acids and peptides in Caco-2 cells and in normal and TNBS-induced rats. Given the potential beneficial applications of AstraGin for health, the effects on L-arginine uptake and nitric…
- Trial name
- NCT05024123
- Testing
- AstraGin
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Acute Kidney Injury
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial…
- Trial name
- NCT07718373
- Testing
- L-arginine
- Volunteers
- 5,000 people
- Sponsor
- Xijing Hospital
Dystrophinopathy, Duchenne Muscular Dystrophy
Safety, Tolerability and Effects of L-Arginine in Boys With Dystrophinopathy on Corticosteroids
The purpose of the study is to assess the safety, tolerability, and effects of L-Arginine on muscles in boys with dystrophinopathy on corticosteroids.
- Conditions
- Dystrophinopathy, Duchenne Muscular Dystrophy, Becker's Muscular Dystrophy
- Trial name
- NCT01388764
- Testing
- L-arginine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes
Effect of Arginine on Microcirculation in Patients With Diabetes
Patients with diabetes have dysfunction of the lining of the arteries which lead to impaired circulation in the small blood vessels. This is thought to be secondary to reduced chemicals in the blood viz: nitric oxide.
- Trial name
- NCT00902616
- Testing
- L-arginine
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Tameside Hospital NHS Foundation Trust
Carpal Tunnel Syndrome
Pain Reduction Caused by the Combined Treatment of Physiotherapy, Oral Gabapentin and Oral Ibuprofen Arginine.
In the present investigation the pain reduction effects of a physiotherapy technique combined with gabapentin and ibuprofen arginine will be compared to those produced by an ibuprofen arginine (only) treatment, in subjects who…
- Trial name
- NCT06781489
- Testing
- Median nerve neural mobilization, Gabapentin 300mg, Ibuprofen Arginine
- Where
- Venezuela
- Volunteers
- 129 people
- Sponsor
- Universidad Europea de Madrid
Vasopressin Deficiency
Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (6 IU and 24 IU) vs.
- Trial name
- NCT04789148
- Testing
- Intranasal Oxytocin (IN-OXT) 6 IU single dose, Intranasal Oxytocin (IN-OXT) 6 IU repeat dose, Intranasal Oxytocin (IN-OXT) 24 IU single dose
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Elizabeth Austen Lawson
Beta-Thalassemia
Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia
OBJECTIVES: I. Determine whether arginine butyrate with or without epoetin alfa can stimulate gamma-globin chain production to a degree that decreases anemia and results in hematologic improvement in patients with thalassemia…
- Trial name
- NCT00006136
- Testing
- arginine butyrate, epoetin alfa
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Boston University
Hunger
Effect of Supplement on Appetite and GLP-1
Study Summary The goal of this study is to understand whether a dietary supplement containing L-arginine, resveratrol, tart cherry, and vitamin C reduces hunger and increases the release of GLP-1, a hormone associated with…
- Trial name
- GLP-1 Suppleme (NCT06790771)
- Testing
- High Dose Supplement, Low Dose Supplement
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Texas Christian University
Healthy
Arginine Synthesis in Healthy Adult Humans
Arginine synthesis in mammals is a complex process involving at least 8 enzymes and intracellular and interorgan transfer of substrates.
- Trial name
- NCT01912235
- Testing
- 2-15N glutamine, 15N2 arginine and 15N proline, 1-13C glutamine
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment
A single centre, placebo controlled, blinded (participant, investigator, outcome assessor) trial to evaluate the effects of COX-2 inhibition with celecoxib on endothelial function in healthy male volunteers.
- Trial name
- ASCENT (NCT04765644)
- Testing
- Celecoxib, L-arginine + celecoxib
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bioequivalence
Bioequivalence Study of Perindopril Tablets in Healthy Volunteers Under Fasting Conditions
This is an open-labeled, randomized, two period, single-center, crossover, comparative study, where each participant will be randomly assigned to the reference (Prestarium ® A 10 mg tablets) or the test (Perindopril 8 mg tablets)…
- Trial name
- NCT06213610
- Testing
- Perindopril tablet, Prestarium® A tablet
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pharmtechnology LLC
Solid Tumor Cancer
Safety and Efficacy of an Arginine-Restricted Diet in Patients With Solid Tumors
This is a phase I single-arm clinical study conducted by West China Hospital of Sichuan University. The research duration is from March 2025 to March 2027, aiming to evaluate the safety and efficacy of arginine-restricted diet…
- Trial name
- NCT07038044
- Testing
- Arginine-restricted diet
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- West China Hospital
Central Diabetes Insipidus
Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls
The investigator hypothesize that low-dose MDMA (3,4-methylenedioxymethamphetamine) will produce a sufficiently strong oxytocin stimulation in healthy controls and no relevant increase in patients.
- Trial name
- OxyMAX (NCT06789705)
- Testing
- MDMA
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland