Clinical trials: Arginine
Dental Caries
2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste
The objective of this study is to evaluate the anticaries efficacy for three dentifrices (1.5% arginine in a calcium base, 8.0% arginine in a calcium base, and 0.32% sodium fluoride in a silica base) in a two-year caries clinical…
- Trial name
- NCT05560945
- Testing
- 0.32% Sodium Fluoride Dentifrice Toothpaste, 1.5% Arginine Dentifrice, 8.0% Arginine Dentifrice
- Where
- 3 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Cancer, Pediatric Solid Tumor
A Study Evaluating the Safety and Activity of Pegylated Recombinant Human Arginase (BCT-100)
PARC is an international phase I/II trial evaluating the safety and activity of pegylated recombinant human arginase (BCT-100) in children and young people with relapsed/refractory leukaemia, neuroblastoma, sarcoma and high grade…
- Conditions
- Cancer, Pediatric Solid Tumor, Pediatric AML, Pediatric ALL
- Trial name
- PARC (NCT03455140)
- Testing
- PEG- BCT-100
- Where
- 14 sites in Australia, Netherlands and 1 more
- Volunteers
- 49 people
- Sponsor
- University of Birmingham
Diabetes Insipidus, Polydipsia, Primary
Use of Copeptin Measurement After Arginine Infusion for the Differential Diagnosis of Diabetes Insipidus - the CARGOx Study
The differential diagnosis of central diabetes insipidus (cDI) is difficult and the current test with the highest diagnostic accuracy is copeptin measurement after hypertonic saline infusion (HIS).
- Trial name
- CARGOx (NCT03572166)
- Testing
- Arginine infusion, Hypertonic saline infusion
- Where
- 7 sites in Brazil, Germany and 4 more
- Volunteers
- 177 people
- Sponsor
- University Hospital, Basel, Switzerland
Fracture Healing, Atrophic Non Union Development
Arginine and Nitric Oxide (NO) Early Prognostic Markers for Non-union Development
Objective: Primary objective is to study the arginine-NO metabolism during fracture healing and dysfunctional fracture healing. Secondary objective: to investigate if differences or decreased arginine and NO concentrations in…
- Conditions
- Fracture Healing, Atrophic Non Union Development, Hypertrophic Non Union Development
- Trial name
- NCT01070576
- Testing
- no intervention
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
Blood Flow Restriction, Growth Hormone
The Effect of Blood Flow Restriction With and Without Arginine on Physical Performance and Growth Hormone
The current study will investigate the effects of Blood Flow Restriction (BFR) training and L-arginine supplementation on recreationally trained female participants.
- Conditions
- Blood Flow Restriction, Growth Hormone, Strength Outcomes, Arginine
- Trial name
- NCT04079010
- Testing
- BFR, Arginine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Mary Hardin-Baylor
Hypertension
Impact of Citrulline and Arginine Supplementation on the Post-exercise Hypotension (PEH)
Post-exercise hypotension (PEH) is a established phenomenon as one of the non-pharmacological ways of reducing blood pressure, producing important impacts, particularly in hypertensive individuals.
- Trial name
- PEH (NCT03378596)
- Testing
- L-citrulline + L-arginine, L-arginine, L-citrulline
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Juliano Casonatto
Peripheral Vascular Disease, Claudication
Oral Nutritional Supplement in Reducing Surgical Site Infections
The study aims to evaluate the efficacy of an arginine enriched oral nutritional supplement in the prevention of wound complications in the the wounds of patients post lower limb revascularization.
- Trial name
- NCT02475525
- Testing
- Arginine enriched oral nutritional supplement
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- University of Limerick
Melanoma (Skin)
Pegylated Arginine Deiminase in Treating Patients With Metastatic Melanoma That Cannot Be Removed by Surgery
RATIONALE: Pegylated arginine deiminase may stop the growth of tumor cells by taking away an amino acid needed for cell growth. PURPOSE: This phase II trial is studying how well pegylated arginine deiminase works in treating…
- Trial name
- NCT00450372
- Testing
- ADI-PEG-20, Pharmacology Studies
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Miami
Alveolar Bone Resorption
Vertical Ridge Augmentation Using Computer-guided Sandwich Osteotomy Technique
Researcher will introduce the trial to patients and provide full explanation of its aim and benefits in Arabic language. Patients will then be able to have an informed discussion with the researcher.
- Trial name
- RGD (NCT07028606)
- Testing
- Sandwich technique with xenograft, collagen membrane and simultaneous implant placement., Sandwich technique with (RGD), xenograft, collagen membrane and simultaneous implant placement.
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Al-Azhar University
Coronary Artery Disease
Endothelial Modulation for Angiogenic Therapy
Coronary artery disease is the single most important killer of Canadians. Despite major advances in therapy, there is still a significant proportion of patients identified with the disease who die of it because current treatment…
- Trial name
- NCT00134433
- Testing
- intramyocardial VEGF angiogenesis (at a dose of 2 mg), oral L-arginine supplementation (at a dose of 6 g/day)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Metabolic Disorder, Arginine; Hyperaminoaciduria
Evaluation of Arginine in Periodontal and Cardiovascular Disease
Asymmetric dimethylarginine (ADMA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD).
- Trial name
- NCT03873948
- Testing
- Evaluation of arginine serum level
- Where
- Italy
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of Messina
Postmenopausal, Overweight and Obesity
Markers of Atherosclerosis in Overweight, Postmenopausal Women Following Daily Watermelon Consumption
The primary purpose of this study is to determine the effectiveness of six weeks of watermelon puree supplementation, compared to control (no treatment), on blood antioxidant capacity, inflammation markers in the blood…
- Trial name
- NCT04015544
- Testing
- Watermelon
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Carpal Tunnel Syndrome
Ibuprofen Arginine and Neural Mobilization Versus Ibuprofen Arginine in the Treatment of Carpal Tunnel Syndrome
In the present investigation the pain reduction effects of a physiotherapy technique combined with pharmaceutical ibuprofen arginine treatment will be compared to those produced by ibuprofen (only) treatment, in subjects who…
- Trial name
- NCT06778759
- Testing
- median nerve neural mobilization combined with oral ibuprofen arginine, Ibuprofen Arginine
- Where
- Venezuela
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Melanoma, Prostate Adenocarcinoma
Recombinant Human Arginase 1 (rhArg1) in Patients With Advanced Arginine Auxotrophic Solid Tumors
The goal of this clinical research study is to evaluate the safety of PEG-BCT- 100 given as an infusion to treat patients who bear advanced solid tumors that are dependent on arginine (melanoma, renal cell carcinoma, prostate…
- Trial name
- NCT02285101
- Testing
- PEG-BCT-100
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Bio-Cancer Treatment International Limited
Arginine Vasopressin Deficiency, Primary Polydipsia
Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome
The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which…
- Trial name
- COMPASS (NCT07569861)
- Testing
- Mannitol, Hypertonic Saline
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- University Hospital, Basel, Switzerland
Preeclampsia
Efficacy and Safety of L Arginine to Prevent Preeclampsia
Randomized double-blind controled clinical trial to assess the efficacy and safety of L-arginine to prevent preeclampsia. applied to pregnant women with risk factors for preeclampsia.
- Trial name
- NCT02363348
- Testing
- L arginine
- Where
- Mexico
- Volunteers
- 96 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Exercise Induced Hyponatremia
The Effects of Estradiol and Progesterone on Arginine Vasopressin Regulation and Serum Sodium Concentration
Women are at greater risk for exercise-induced hyponatremia (low blood sodium concentration) and this risk has been attributed to their lower body weight and size, excess water ingestion and longer racing times relative to men.
- Trial name
- NCT00589134
- Testing
- Gatorade Endurance Formula, ganirelix acetate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yale University
Plaque, Dental
Arginine Plaque Metabolism Pilot Clinical Study
Proof of concept clinical study to measure plaque metabolism and the prebiotic efficacy of arginine-containing toothpaste.
- Trial name
- NCT06954779
- Testing
- Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Radiation Mucositis, Head and Neck Cancer
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial
Oral Mucositis (OM) is a painful inflammation and ulceration of the oral mucosa, often resulting from cancer treatments like chemotherapy and radiation therapy, particularly in head and neck cancer patients.
- Trial name
- NCT06764420
- Testing
- Glutamine Oral Suspension, Arginine and Glutamine Oral Suspension
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Hypertension
Observational Cohort Study Evaluating the Effectiveness of an Educational Program (NGAYDAUTIEN) in Combination With Perindopril and Amlodipine Single-Pill Combination in Hypertensive Patients naïve of Antihypertensive Treatments.
The primary objective is to assess the change of systolic blood pressure from baseline after a 6-month follow up for hypertensive patients initiating Viacoram® plus an educational program (NGAYDAUTIEN) in comparison to…
- Trial name
- EDUHYPER (NCT06704815)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Servier Affaires Médicales