Clinical trials: Arrhythmia, Cardiac
Atrial Fibrillation, Atrial Fibrillation Ablation
Comparison of Pulmonary Vein Isolation Using SmartTouch® Catheter With or Without Real-time Contact Force Data
The most widely used approach for the invasive treatment of paroxysmal atrial fibrillation is catheter ablation, by which radiofrequency energy is used to heat the tip of an ablation catheter to deliver targeted burns on the…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation Ablation, Pulmonary Vein Isolation
- Trial name
- NCT01730924
- Testing
- Pulmonary vein isolation using contact force sensing catheter
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Queen Mary University of London
Cardiac Arrhythmia, Cardiomyopathy, Dilated
The Rhytmia System to Determine the Precise Location and Potential Mechanism of Premature Contractions
This is a purely observational project and the objectives are to record and analyze the local potentials at the site of Premature Ventricular Contraction (VPC) focus through the Rhythmia system, ti determine the short and…
- Trial name
- RhytmiaPVC (NCT03460535)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Non-valvular Atrial Fibrillation (AF)
Vortosiran in Atrial Fibrillation
This is a randomised, actively controlled Phase IIb trial to evaluate the safety and pharmacodynamics (PD) of two blinded doses of subcutaneously administered vortosiran and open-label apixaban in patients with AF.
- Trial name
- NCT07870889
- Testing
- Vortosiran, Apixaban
- Where
- 15 sites in Denmark, Norway and 2 more
- Volunteers
- 150 people
- Sponsor
- Ribocure Pharmaceuticals AB
Coronary Heart Disease, Arrhythmia
ECG and VCG in Dependence of Body Posture
The electrocardiogram (ECG) is an important diagnostic procedure in medicine mainly to detect circulation disorders and problems of the spread of the electrical heart impulse.
- Trial name
- EVER (NCT02094989)
- Testing
- posture dependence of VCG-ECG-transformation
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Brugada Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy
Diagnostic Value and Safety of Flecainide Infusion Test in Brugada Syndrome
The study aims to use flecainide infusion test as diagnostic test to unmask concealed Brugada Syndrome cases. It proposes to assess the safety profile of this test in US patients and its higher sensitivity when compared to…
- Trial name
- NCT02302274
- Testing
- flecainide iv
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- NYU Langone Health
Sick Sinus Syndrome, AV Block
HBP Device EGM Data Collection
This is a single-arm, non-randomized, non-blinded study designed to collect device data in patients with permanent His bundle (HB) pacing lead and an existing Abbott permanent pacemaker, defibrillator, or cardiac…
- Conditions
- Sick Sinus Syndrome, AV Block, Heart Failure
- Trial name
- NCT03564860
- Testing
- Device data collection
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation Paroxysmal
The Effect of a Case-finding App on the Detection Rate of Atrial Fibrillation in Primary Care Patients
Atrial fibrillation is a cardiac arrhythmia commonly encountered in a primary care setting. Current screening is limited to pulse palpation and ECG confirmation when an irregular pulse is found.
- Trial name
- NCT04545723
- Testing
- FibriCheck
- Volunteers
- healthy volunteers welcome
- Sponsor
- KU Leuven
Atrial Fibrillation
Cardiac Surgical Treatment by Radiofrequency Ablation on Valvular Patients: Efficacy at 3 Months
The objective of the study is to evaluate the efficacy of the epicardial or endocardial radiofrequency ablation in the treatment of atrial fibrillation.
- Trial name
- NCT00259623
- Testing
- Radiofrequency ablation
- Where
- 5 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Arrhythmia, Cardiovascular Diseases
Diagnostic Investigation of Sudden Cardiac Event Risk
The overall objective of the DISCERN study is to develop and validate a genomic diagnostic assay to identify patients at increased risk for lethal ventricular arrhythmias and sudden cardiac death (SCD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Failure, CVD
- Trial name
- DISCERN (NCT00500708)
- Where
- 8 sites in United States
- Volunteers
- 1,564 people
- Sponsor
- CardioDx
Atrial Fibrillation
Low Dose of Diltiazem for Rate Control of Atrial Fibrillation
This study is to show the efficacy and safety of low dose diltiazem for the treatment of atrial fibrillation with rapid ventricular response in emergency room.
- Trial name
- NCT00834925
- Testing
- low dose diltiazem
- Where
- South Korea
- Volunteers
- 380 people
- Sponsor
- Seoul National University Hospital
Atrial Fibrillation New Onset
MAGNAM Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care
A multi-centre, non-blinded, comparative effectiveness, randomised controlled trial. Patients will be prospectively enrolled from Critical Care Units and will be assessed for study enrollment based on inclusion/exclusion criteria…
- Trial name
- MAGNAM (NCT05287191)
- Testing
- Magnesium sulfate and then Digoxin, Amiodarone
- Where
- 5 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bradyarrhythmia, Atrioventricular Block
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period.
- Conditions
- Bradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area Pacing
- Trial name
- NCT05585411
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Yonsei University
Long QT Syndrome
Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
This study will evaluate the effect of oral GS-6615 on QTc interval in healthy adults with dofetilide-induced QTc prolongation.
- Trial name
- NCT02365532
- Testing
- GS-6615, Dofetilide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Atrial Fibrillation
Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation
The purpose of this study is to determine whether it is safe to stop anticoagulation medication in patients with a history of atrial fibrillation (AF) based on information from a pacemaker or implantable cardioverter…
- Trial name
- TACTIC AF (NCT01650298)
- Testing
- Drug (Direct thrombin or Factor Xa inhibitor)
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
Atrial Fibrillation Recurrence After Cryoballoon Ablation
The purpose of the study is to evaluate the mechanisms of recurrent atrial fibrillation after cryoballoon ablation using the Arctic Front Ablation System.
- Trial name
- NCT01772030
- Testing
- Use of the Achieve catheter followed by ICE-guided mapping catheter
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Coronary Artery Disease, Atrial Fibrillation (AF)
Medical Large Language Model-Assisted Diagnosis and Treatment in Primary Care Chronic Disease Management
This study aims to explore the feasibility of using medical large language models to assist in chronic disease management. By setting up experimental and control group interventions and having experts blindly evaluate anonymized…
- Conditions
- Coronary Artery Disease, Atrial Fibrillation (AF), Heart Failure, Stroke
- Trial name
- NCT07740044
- Testing
- Medical large language model
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Atrial Fibrillation
Use of a High Density Mapping System to Complete Wide Area Circumferential Ablation of the Pulmonary Veins and Avoid Ostial Segmental Ablation
This is a prospective, multicentre, randomized single blind, parallel group study to be conducted in the UK (2 sites).Approximately 48 patients will be recruited aiming for 40 eligible for randomization.
- Trial name
- HD-WACA (NCT02917044)
- Testing
- Atrial Fibrillation Ablation, Catheters used to isolate pulmonary veins, Atrial Fibrillation Ablation with HD mapping to isolate PVs
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Imperial College Healthcare NHS Trust
Atrial Fibrillation
Safety and Feasibility of Atrial Deganglionation as Adjunctive Therapy for AF
A prospective, single arm, multi-center exploratory study of safety and feasibility in the treatment of patients undergoing cardiothoracic surgery.
- Trial name
- Neural-AF (NCT04775264)
- Testing
- Pulsed Electric Field Ablation
- Where
- 2 sites in Czechia, Georgia
- Volunteers
- 24 people
- Sponsor
- Atrian Medical Ltd.
Atrial Fibrillation
Surgical Ablation for Atrial Fibrillation
Minimally invasive approaches for surgical treatment have been advocated as a treatment option for stand-alone atrial fibrillation (AF).
- Trial name
- NCT04398979
- Testing
- Thoracoscopic Atrial fibrillation Ablation
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Pulmonary Disease, Chronic Obstructive
Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid of carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2 and CO2.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxemia
- Trial name
- NCT00888342
- Testing
- supplementary oxygen, zopiclone, alcohol
- Where
- 2 sites in Norway
- Volunteers
- 150 people
- Sponsor
- LHL Helse