Clinical trials: Arterial Aneurysm
Subarachnoid Hemorrhage, Hypertension
Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage
This study is designed to assess how rapidly and how safely Clevidipine can be used to control high Blood Pressure in patients with subarachnoid hemorrhage which is a type of brain bleed that happens because of a weak balloon…
- Trial name
- CLASH (NCT00978822)
- Testing
- Clevidipine butyrate injectable emulsion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Intracranial Aneurysm
Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm
The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms.
- Trial name
- EODHS-IA (NCT05749393)
- Testing
- Heparin sodium
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Intracranial Aneurysms
TARGET Intracranial Aneurysm Coiling Registry
The purpose of this prospective registry is to collect real world, post-marketing data on the use of Stryker Target® 360,Target® 2D, and 2nd generation Target® Nano coils for the embolization of ruptured or unruptured…
- Trial name
- TARGET (NCT01748903)
- Testing
- Target 360°, 2D Coils, Nano Coils
- Where
- 9 sites in United States
- Volunteers
- 150 people
- Sponsor
- Mercy Health Ohio
Aortic Aneurysm, Abdominal
Impact of Grafts and Endografts for Abdominal Aneurysms on Arterial Stiffness.
The purpose of this study is to evaluate by non-invasive methods the change in central hemodynamics and arterial stiffness produced by grafts and endografts after abdominal aortic aneurysm repair.
- Trial name
- NCT02642952
- Testing
- non-invasive methods
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Intracranial Aneurysms
Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization
Intracranial aneurysm treatment with coil embolization is associated with relatively low complete occlusion and high recanalization rates.
- Trial name
- NCT01029938
- Testing
- Covered stent, Coil
- Where
- 2 sites in China
- Volunteers
- 85 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Intracranial Aneurysms
TRAIL: Treatment of Intracranial Aneurysms With LVIS® System
A prospective, multicenter, observational assessment of the safety and effectiveness of the LVIS® device in the treatment of wide necked intracranial aneurysms.
- Trial name
- TRAIL (NCT02921711)
- Testing
- LVIS®
- Volunteers
- 90 people
- Sponsor
- Microvention-Terumo, Inc.
Intracranial Aneurysm
Efficacy and Safety of the Self-expanding Intracranial Stent (Tonbridge) for Endovascular Treatment of Intracranial Aneurysms
The purpose of this study is to assess the efficacy and safety of Self-expanding Intracranial Stent (Tonbridge), by comparing the data obtained from Self-expanding Intracranial Stent (Zhuhai Tonbridge Medical Tech.
- Trial name
- NCT05755516
- Testing
- Self-expanding Intracranial Stent (Tonbridge), LVIS and LVIS Jr. (MicroVention)
- Where
- 14 sites in China
- Volunteers
- 204 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Wide Neck Bifurcation Intracranial Aneurysms, Intracranial Aneurysms
The WEB-IT Clinical Study
The study is a prospective, multicenter single-arm cohort. Patients with wide neck bifurcation aneurysms (WNBAs) have few choices for safe and effective endovascular treatment.
- Trial name
- WEB-IT (NCT02191618)
- Testing
- WEB
- Where
- 32 sites in United States, Canada and 4 more
- Volunteers
- 150 people
- Sponsor
- Microvention-Terumo, Inc.
Atherosclerosis, Aneurysm
A Feasibility Study of the Cordis Neurovascular Self Expanding Stent System in Intracranial Arteries
Feasibility study to assess safety of treating patients with self expanding stent in intracranial arteries.
- Trial name
- NCT00349908
- Testing
- Cordis Neurovascular ENTERPRISE Self Expanding Stent System
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Codman & Shurtleff
Artery; Dilatation
Safety and Tolerability of Nitro for Radial Artery Dilation
Phase 1, single-center, open-label clinical study to assess the safety and efficacy of topical nitroglycerin on dilation of the radial artery.
- Trial name
- RADial (NCT05239013)
- Testing
- Nitroglycerin ointment
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Intracranial Aneurysm
The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).
The purpose of this study is to assess the safety and effectiveness of the Artisse™ Intrasaccular Device in the treatment of unruptured and ruptured wide-neck bifurcating intracranial aneurysms.
- Trial name
- ARTISSE (NCT02998229)
- Testing
- Artisse™ Intrasaccular Device
- Where
- 25 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm
General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Using Flow Diverter
The prevalence of unruptured intracranial aneurysm (UIA) in the population is about 2%-7%, and once it ruptures and bleeds, the rate of disability and death is extremely high, with 10%-15% of patients dying suddenly before they…
- Trial name
- GALA-FD (NCT06416657)
- Testing
- Different anesthesia methods, namely local anesthesia and general anesthesia
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Ming Lv
Coronary Artery Disease, Aortic Valve Disease
Clinical Evaluation of a Modular Extracorporeal Circulation Circuit
The purpose of this clinical research study is the design of a novel modular hybrid system extracorporeal circulation circuit for open heart procedures that could easily be converted from a closed to a semi-closed circuit…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease, Aortic Aneurysm
- Trial name
- MiECC MODULAR (NCT02000544)
- Testing
- Modular Cardiopulmonary Bypass Circuit
- Where
- Greece
- Volunteers
- 403 people
- Sponsor
- AHEPA University Hospital
Common Iliac Artery Aneurysms, Aorto-iliac Aneurysms
Evaluation of the GORE® EXCLUDER® Iliac Branch Endoprosthesis
The Iliac Branch Endoprosthesis (IBE) 12-04 study will be a prospective, nonrandomized, multicenter, single-arm evaluation designed to assess the safety and efficacy of the IBE Device in subjects with common iliac artery…
- Trial name
- NCT01883999
- Testing
- GORE® EXCLUDER® Iliac Branch Endoprosthesis
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- W.L.Gore & Associates
Intracranial Aneurysms
A Better Choice for Patients Undergoing Endovascular Coil Embolization
The investigators designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine on the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.
- Trial name
- NCT01722409
- Testing
- sevoflurane and 0.5 μg/kg dexmedetomidine, sevoflurane and 1 μg/kg dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- China Medical University, China
Intracranial Aneurysm
Intelligent Microcatheter Shaping for Intracranial Aneurysm Coil Embolization
This prospective, multicenter, observational registry study will evaluate the real-world safety, effectiveness, and clinical value of artificial intelligence (AI)-assisted microcatheter shaping during coil embolization of…
- Trial name
- NCT07749404
- Testing
- Physician-Experience Microcatheter Shaping, AI-Assisted Microcatheter Shaping Simulation Technology
- Where
- China
- Volunteers
- 1,438 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Aneurysm, Brain Aneurysm
The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices
Intracranial bifurcation aneurysms are commonly repaired with surgical and with endovascular techniques. Wide-necked bifurcation aneurysms (WNBA) are a difficult subset of aneurysms to successfully repair endovascularly, and a…
- Conditions
- Intracranial Aneurysm, Brain Aneurysm, Unruptured Cerebral Aneurysm, Ruptured Cerebral Aneurysm
- Trial name
- RISE (NCT03936647)
- Testing
- surgical clipping, simple coiling, high-porosity stenting with/ without coiling, intra-arterial flow diversion with/ without coiling, WEB embolization device
- Where
- 4 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Thoracic Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs)
MBA Early Feasibility Study
The MBA 25-04 study is a prospective, multicenter, non-randomized, single-arm, early feasibility study designed to assess the initial safety of the MBA device through five years following the index endovascular procedure.
- Conditions
- Thoracic Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs), Thoracic Aortic Dissection, Pseudoaneurysm
- Trial name
- NCT07564375
- Testing
- GORE® Multibranch Arch Endoprosthesis, GORE® Ascending Stent Graft
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- W.L.Gore & Associates
Middle Cerebral Artery Aneurysm
Middle Cerebral Artery Aneurysm Trial
Intracranial aneurysms located on the middle cerebral artery (MCA) are considered by many surgeons to represent a distinct subgroup of aneurysms for which clipping may still be the best management option.
- Trial name
- MCAAT (NCT05161377)
- Testing
- Surgical management, Endovascular management
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Alberta
Intracranial Aneurysm
Stenting in the Treatment of Aneurysm Trial
The STAT trial aims at comparing coiling versus coiling plus stenting in patients with aneurysms prone to recurrence, that is large aneurysms or recurring aneurysms after previous coiling or wide-necked aneurysms.
- Trial name
- STAT (NCT01340612)
- Testing
- endovascular coiling with any type of currently approved coil (first or second generation), endovascular stenting with or without coiling. The stent may be any of the currently approved stents for intracranial aneurysms.
- Where
- 5 sites in Canada, France
- Volunteers
- 205 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)