Clinical trials: Arterial Calcification
Coronary Artery Calcification, Vascular Calcification
Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients
Vascular calcification is a frequent complication in dialysis patients and is strongly associated with mortality. Its pathogenesis is complex and involves a series of markers that act on the vascular microenvironment.
- Trial name
- NCT03314493
- Testing
- Spironolactone 25Mg Tablet
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Coronary Arterial Disease (CAD), In Stent Restenosis
OPN Balloon for SAFE Recanalization of Calcified Coronary Lesions
The goal of the OPEN-SAFE registry is to describe the contemporary use and outcomes of SIS-OPN in North America.
- Conditions
- Coronary Arterial Disease (CAD), In Stent Restenosis, Calcified Coronary Lesions
- Trial name
- OPEN-SAFE (NCT07646444)
- Testing
- non compliant balloon
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Minneapolis Heart Institute Foundation
Arterial Calcification, Aortic Stiffness
Short and Long-term Results of Arterial Stiffness and Central Aortic Pressure After Kidney Transplantation
Central blood pressure and pulse wave velocity were measured using a Complior Analyse device in Short and Long-term after kidney transplantation.
- Conditions
- Arterial Calcification, Aortic Stiffness, High Blood Pressure (& [Essential Hypertension])
- Trial name
- PWV/CP/KTx (NCT02443454)
- Testing
- Device: Complior Analyse System, Tanita BC 418- Bioelectrical impedance analysis
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Chronic Kidney Disease
Tissue-nonspecific Alkaline Phosphatase in Phosphate and Pyrophosphate Homeostasis.
Vascular calcification is a common finding in chronic kidney disease and increases arterial stiffness leading to augmented cardiovascular morbidity.
- Trial name
- PIPAL (NCT03520738)
- Testing
- Blood samples, Urinary samples
- Where
- 4 sites in France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Kidney Disease
CRICKET Study, Coronary Calcium Scores in Patients With Chronic Kidney Disease
Patients with Chronic Kidney Disease (CKD) have been shown to have high coronary calcium scores (CAC), but the temporal association between Glomerular Filtration Rate, CVD risk factors and CAC has not been described.
- Trial name
- NCT00142636
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Breast Cancer, Vascular Calcification
Tissue Validation of Mammographic Breast Arterial Calcification in Mastectomy Specimens
Breast arterial calcification (BAC) is a common incidental finding on screening mammograms and has been associated with cardiovascular disease in women. However, every study in this field has been imaging-based.
- Conditions
- Breast Cancer, Vascular Calcification, Coronary Artery Calcification, Atherosclerosis Cardiovascular Disease
- Trial name
- SIDEMARA (NCT07865884)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Coronary Artery Calcification, Intravascular Lithotripsy
Prognostic Impact of Coronary Microvascular Dysfunction After IVL Versus RA in Patients With Severe Coronary Calcification Undergoing PCI
The goal of this observational study is to lean that whether the distinct mechanisms by which intravascular lithotripsy (IVL) and rotational atherectomy (RA) treat severe coronary calcification differentially affect the…
- Conditions
- Coronary Artery Calcification, Intravascular Lithotripsy, Coronary Microcirculation Dysfunction
- Trial name
- NCT07699965
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atherosclerosis, Stroke
Metabolic Imaging in Carotid Atherosclerosis
Hardening of the arteries (atherosclerosis) is a common disorder that causes heart attacks and strokes. PET CT and contrast-enhanced MRI scans are two new ways of assessing atherosclerosis.
- Trial name
- MICA (NCT01674257)
- Testing
- USPIO (ferumoxytol)-enhanced MRI scan, 18f-Fluoride PET/CT scan, 18F-Flurodeoxyglucose PET/CT scan
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Myocardial Ischaemia, Severely Calcified Coronary Stenoses
Implementation of a Standardized Algorithm for Coronary Calcification With Plaque Modification
In this study, the doctors will follow a set of rules that is called an algorithm. An algorithm is a step-by-step approach that doctors use to guide them when making decisions about the best way to treat their patients.
- Conditions
- Myocardial Ischaemia, Severely Calcified Coronary Stenoses, Coronary Calcification
- Trial name
- CYCLOPES (NCT06678594)
- Testing
- Calcium modification
- Where
- Ireland
- Volunteers
- 500 people
- Sponsor
- Royal College of Surgeons, Ireland
Coronary Artery Calcification
Melatonin and Coronary Artery Calcification
The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.
- Trial name
- NCT03967366
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Chinese PLA General Hospital
Carotid Artery Stenosis
Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial)
Clinical Trial Summary Trial Title:** CREATE Trial: Safety and Efficacy of IVL for Carotid Calcified Lesions Sponsor:** Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
- Trial name
- CREATE (NCT06936176)
- Testing
- Neurovascular Intravascular Shockwave Catheter
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Cardiovascular Disease (CVD)
Cardiovascular Risk Assessment and Coronary Calcium Score in Thai MASLD Patients
Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in Thailand and is strongly linked to metabolic risk factors such as obesity, diabetes, hypertension, and dyslipidemia.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Cardiovascular Disease (CVD), Coronary Artery Calcification
- Trial name
- MASLD-CAC (NCT07865936)
- Where
- Thailand
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Watcharasak Chotiyaputta
Heterozygous Familial Hypercholesterolemia (HeFH)
"Detection and Follow-up of Coronary Lesions in HeFH (DESTINY-FH Study)"
This multicenter, non-randomized interventional study aims to assess coronary artery disease progression over 5 years in patients with genetically confirmed heterozygous familial hypercholesterolemia (HeFH), using coronary…
- Trial name
- DESTINY-FH (NCT07427472)
- Testing
- Coronary computed tomography angiography
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Moderate to Severe Calcified Coronary Artery Stenosis
Clinical Trial of T-wave™ Coronary Lithotripsy Catheter System
A prospective, multi-center, single-group target value method was used in this study. According to the inclusion criteria stipulated in this trial protocol, > 3 medical device clinical trial institutions with the record of the…
- Trial name
- NCT05552131
- Testing
- T-wave coronary lithotripsy catheter system
- Volunteers
- 190 people
- Sponsor
- Suzhou Zhonghui Medical Technology Co., Ltd.
Coronary Artery Disease, Carotid Artery Disease
Effects of VitamIN K2 and D3 supplementaTion on PET/MRI in Carotid Artery Disease
Atherosclerosis is a disease of the arteries and is the result of various factors such as high blood cholesterol or diabetes, which lead to accumulations of fats, cells, and calcium deposits (i.e. plaques).
- Trial name
- INTRICATE (NCT04010578)
- Testing
- MK-7 and vitamin D3
- Volunteers
- 52 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Coronary Artery Disease
Atherectomy vs Intravascular Lithotripsy
Preliminary experiences show that IVL is promising for achieving an effective plaque modification at time of PCI. However, uncertainty about the optimal tool to select in case of calcification of coronary lesions exists, as no…
- Trial name
- RAINBOW (NCT04013906)
- Testing
- Rotational atherectomy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Vascular Calcification
Comparison of RA-IVL and RA-SHP in Calcified Coronary Lesions
Study Design Prospective, multicenter, single-blind, randomized controlled trial Hypothesis In patients with severely calcified coronary lesions undergoing rotational atherectomy (Rota), post-rotational lesion optimization using…
- Trial name
- CRUSH-CALC (NCT07279987)
- Testing
- Super High-Pressure Non-Compliant Balloon, Intravascular Lithotripsy System
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Lin Zhao
Chronic Kidney Disease, End Stage Renal Disease
ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis
The purpose of this study is to evaluate whether cinacalcet + low dose vitamin D attenuates the progression of vascular calcification over one year, compared with a treatment regimen that includes flexible vitamin D dosing in the…
- Conditions
- Chronic Kidney Disease, End Stage Renal Disease, Coronary Artery Calcification, Vascular Calcification
- Trial name
- NCT00379899
- Testing
- cinacalcet
- Volunteers
- 360 people
- Sponsor
- Amgen
Primary Prevention, Vascular Calcification
GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification
A Multicenter, randomized trial comparing the efficacy and safety of intensive lipid-lowering therapy using a statin-ezetimibe combination without aspirin versus statin monotherapy with aspirin in asymptomatic patients with…
- Trial name
- NCT06722521
- Testing
- Pitavastatin 4mg and ezetimibe 10mg, taken once daily, Pitavastatin 2 mg with aspirin 100 mg, taken once daily.
- Where
- South Korea
- Volunteers
- 7,435 people
- Sponsor
- Asan Medical Center
Coronary Arterial Disease (CAD), Calcification; Heart
The Safety and Performence of ShockPulse-10 in Patients with Coronary Artery Calcification
This study is an exploratory, multicenter, single-group clinical trial aimed to evaluate the clinical outcomes of using ShockPulse-10 in the treatment of coronary artery calcification .
- Trial name
- NCT06711822
- Testing
- Shockplus-10
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Keya Medical