Clinical trials: Arterial Disease
Coronary Artery Stenoses
Five-year Patency of No-touch Saphenous Vein Grafts in On-pump Versus Clamp-less Off-pump Coronary Artery Bypass Surgery
Randomised controlled trials (RCTs) have shown high long-term patency for no-touch saphenous vein grafts (NTSVGs), comparable to the internal thoracic artery in on-pump coronary artery bypass grafting (CABG).
- Trial name
- NCT03447197
- Testing
- The use of extracorporeal circulation
- Volunteers
- 59 people
- Sponsor
- Örebro County Council
Pulmonary Arterial Hypertension
Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arterial Hypertension
The development of selexipag for intravenous administration will be useful to avoid treatment interruptions in patients with pulmonary arterial hypertension (PAH) already treated with selexipag administered orally as tablets…
- Trial name
- NCT03187678
- Testing
- i.v. selexipag, oral selexipag (Uptravi)
- Where
- 8 sites in United States, Germany
- Volunteers
- 20 people
- Sponsor
- Actelion
Peripheral Arterial Disease, Sedentary Behavior
RESPONSE-2-PAD to Reduce Sedentary Time in Peripheral Arterial Disease Patients
The RESPONSE-2- peripheral arterial disease (PAD) program will be implemented to modify sedentary time in patients with PAD. It is an adapted version of the RESPONSE that aims to reduce sedentary behavior in individuals with…
- Conditions
- Peripheral Arterial Disease, Sedentary Behavior, Sedentary Time, Peripheral Arterial Occlusive Disease
- Trial name
- NCT05961943
- Testing
- RESPONSE-2-PAD
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- National Institute for Prevention and Cardiovascular Health, Ireland
Chronic Kidney Disease, Proteinuria
Endothelin Receptor Antagonism in Proteinuric Nephropathy
The number of people with kidney problems is increasing rapidly, related in part to the increasing prevalence of diabetes. Patients with kidney problems tend to have protein leaking into the urine (proteinuria).
- Trial name
- NCT00722215
- Testing
- BQ-123 (selective endothelin A receptor antagonist), 0.9 % saline, Nifedipine
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Type 2, Artery Disease
Arterial Composition and Cardiovascular Outcome in DIabeteS
1. People living with type 2 diabetes are told that they have a significantly higher risk of developing a disease related to the heart or blood vessels.
- Conditions
- Diabetes Mellitus, Type 2, Artery Disease, Protein Deposition
- Trial name
- ACCODIS (NCT04150315)
- Testing
- Proteome analysis
- Where
- Denmark
- Volunteers
- 763 people
- Sponsor
- University of Southern Denmark
Scleroderma, Systemic
The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis
The aim of the study is to investigate whether bosentan added to usual care improves arterial stiffness after 3 months as measured as the pulse wave velocity (PWV) of the medium and large arteries corrected for blood pressure…
- Trial name
- CEASESTIFF (NCT02480335)
- Testing
- bosentan
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Diseases, Myocardial Infarction
The Efficacy of Influenza Vaccine in Reducing Cardiovascular Events in Patients With Coronary Artery Diseases
Influenza vaccine reduces the cardiovascular events in post-myocardial infarction (MI) patients and in those with stable angina (SA).
- Conditions
- Coronary Artery Diseases, Myocardial Infarction, Stable Angina
- Trial name
- IVCAD (NCT00607178)
- Testing
- influenza vaccine
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Hypertension
Effects of Cocoa on Ambulatory Blood Pressure and Vascular Function in Patients With Stage I Hypertension
The proposed study Dose And Response to Cocoa (DARC), will examine variation in dose of cocoa-containing product consumption over an 8-week period and assess effects on blood pressure, endothelial function and arterial stiffness.
- Trial name
- DARC (NCT01672840)
- Testing
- 5g Cocoa Consumption, 10g Cocoa Consumption
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Griffin Hospital
Coronary Artery Disease, Diabetes Mellitus, Type 2
The Effect of Liraglutide on the Treatment of Coronary Artery Disease and Type 2 Diabetes
The purpose of this study is to investigate the effect of combined glucagon-like-peptide-1 (GLP-1) analogue and metformin therapy on glucose metabolic and cardiovascular endpoints compared to metformin monotherapy in patients…
- Trial name
- AddHope2 (NCT01595789)
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Haugaard, Steen Bendix, M.D., DMSc
Coronary Artery Disease
Evaluation of Effectiveness and Safety of PROMUS Element Stent (IRIS-ELEMENT )
This study is a non-randomized, prospective, open-label registry to compare the efficacy and safety of Promus Element stents versus first-generation drug-eluting stent (DES) in patients with coronary artery disease.
- Trial name
- NCT01350791
- Where
- South Korea
- Volunteers
- 3,001 people
- Sponsor
- Seung-Jung Park
Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries
Stratified Medicine of Eplerenone in Acute Myocardial Infarction or Injury and no Obstructive Coronary Arteries.
Patients with heart attack or heart injury are tested (angiogram) for blockages in their arteries. Patients may develop heart problems caused by damage to small (microvascular) blood vessels.
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries, Myocardial Injury
- Trial name
- StratMedMINOCA (NCT05198791)
- Testing
- Stratified medicine - Microvascular dysfunction and eplerenone therapy, tablets, Stratification and standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- NHS National Waiting Times Centre Board
Intracranial Artery Stenosis
Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis
Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemical cerebrovascular events. The risk of stroke recurrence or death of ICAD patients remains very high.
- Trial name
- BASIS (NCT03703635)
- Testing
- intracranial balloon angioplasty, aggressive medical management
- Where
- 31 sites in China
- Volunteers
- 512 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Coronary Artery Disease
An Epidemiological Cohort Study of Acute Coronary Syndromes in The Greek Population. The PHAETHON Study
A nationwide registry of patients with acute coronary disease to evaluate epidemiological patient characteristics, medical management, implementation of invasive strategy, patient outcome and impact on quality of life in Greece.
- Trial name
- PHAETHON (NCT02420808)
- Where
- Greece
- Volunteers
- 800 people
- Sponsor
- Hellenic Cardiovascular Research Society
Chronic Renal Failure of Unknown Cause
CKDu Treated With Intra-arterial Infusion of Autologous SVF Cells
This is an interventional study to treat 18 patients with chronic kidney disease of unknown cause (CKDu), formerly known as Mesoamerican nephropathy (MeN), with autologous adipose tissue-derived stromal vascular fraction (SVF)…
- Trial name
- NCT05154591
- Testing
- Adipose-derived stromal vascular fraction cells
- Where
- Nicaragua
- Volunteers
- 18 people
- Sponsor
- Samuel Vilchez, PhD
Secondary Pulmonary Arterial Hypertension, Sickle Cell Disease
Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria
This study will explore how people with sickle cell disease (SCD) develop a complication called pulmonary hypertension (PHTN), a serious disease in which blood pressure in the lungs is higher than normal.
- Conditions
- Secondary Pulmonary Arterial Hypertension, Sickle Cell Disease, Pulmonary Hypertension
- Trial name
- NCT00367523
- Where
- Nigeria
- Volunteers
- 308 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Arterial Disease
The Jetstream G3™ Calcium Study
To investigate the treatment effects with the Jetstream G3 System in moderate to severely calcified peripheral artery disease in the common femoral, superficial femoral or popliteal arteries using intravascular ultrasound (IVUS).
- Trial name
- NCT01273623
- Testing
- Jetstream Atherectomy System
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Boston Scientific Corporation
Cardiovascular Disease, End Stage Renal Disease
Safety and Tolerability of Coenzyme Q10 in Hemodialysis Patients
The purpose of this study is to determine the safety and tolerability of the dietary supplement Coenzyme Q10 in hemodialysis patients.
- Conditions
- Cardiovascular Disease, End Stage Renal Disease, Atherosclerosis, Oxidative Stress
- Trial name
- NCT00908297
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Peripheral Artery Disease (PAD)
Use of Three-Dimensional Printed Models for Endovascular Planning and Follow-up in Patients Affected by Aorto-Iliac-Femoral-Popliteal Arterial Disease Undergoing Balloon Angioplasty. A Single-center, Single-blind Randomized Controlled Trial
Lower extremity peripheral arterial disease is a major health problem. Currently, balloon angioplasty represents the most commonly performed treatment for patients affected by vascular claudication or critical limb ischemia.
- Trial name
- 3DPAD-1 (NCT07000097)
- Testing
- PTA planning supported by 3D-printed model, PTA (Standard of Care)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Coronary Artery Disease
Assessment of Coronary Flow Reserve by PET-H215O and FFR. Comparison With Dynamic Acquisition Using CZT Camera
The study will assess coronary flow reserve by PET-H215O and FFR in patients suspected of coroanry artery disease. This a comparative study with dynamic acquisition using CZT camera and 99mcTc-mibi.
- Trial name
- WATERDAY (NCT02278497)
- Testing
- ASSESSMENT OF CORONARY FLOW RESERVE BY PET-H215O AND FFR
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Coronary Artery Stenosis
Observational Study to Evaluate Short and Long-term Safety of the ABSORB Scaffold
The German-Austrian ABSORB Register shall provide an analysis of acute and long-term safety as well as therapy outcomes of the ABSORB (trade mark) bioresorbable vascular scaffold system in patients suffering from coronary artery…
- Trial name
- GABI-R (NCT02066623)
- Testing
- ABSORB Scaffold
- Where
- 81 sites in Austria, Germany
- Volunteers
- 3,330 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung