Clinical trials: Arterial Hypotension
Autonomic Nervous System Diseases, Baroreflex Failure
Effects of Water and Glucose Drinks on Cardiovascular Function in Subjects With and Without Postprandial Hypotension
To determine whether the changes in blood pressure (BP) which occur following meals in normal people and patients who have substantial falls in BP after a meal postprandial hypotension (PPH)) are associated with changes in…
- Conditions
- Autonomic Nervous System Diseases, Baroreflex Failure, Blood Pressure, Hypotension
- Trial name
- NCT02713412
- Testing
- Glucose, Water
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Anesthesia
A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia
The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery.
- Trial name
- NCT05954832
- Testing
- Echocardiography
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Intraoperative Hypotension
Bispectral Index Guided Sevoflurane Titration
Electroencephalographic-based monitoring systems such as the bispectral index (BIS) may reduce anaesthetic overdose rates. The investigators hypothesised that goal-directed sevoflurane administration (guided by BIS monitoring)…
- Trial name
- NCT02515019
- Testing
- Bispectral index Monitoring
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension
Cognitive Dysfunction in Hypertensive Patients Having Spine Surgery
While hypotension during general anesthesia has routinely been considered to be a tolerable abnormality with little clinical consequence, the proposed study takes the innovative approach of defining hypotensive events within the…
- Trial name
- HTN (NCT01140854)
- Testing
- Lumbar spine surgery, Neurologic/neuropsychometric examinations
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obstetric Anesthesia Problems
Preloading to Prevent Hypotension During Cesarean Section
Whether the usage of non-invasive arterial blood pressure monitor to guide fluid therapy in caesarean section can effectively reduce the incidence of hypotension and fetal complications.
- Trial name
- NCT03013140
- Testing
- Fluid therapy, Spinal anaesthesia
- Where
- Taiwan
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Multiple System Atrophy, MSA - Multiple System Atrophy
Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early to Moderate Stage Multiple System Atrophy (MSA)
Purpose of this phase 1 study is to assess the safety of intrathecal administration of allogeneic human oral mucosa stem cells (hOMSCs) in patients suffering from early to moderate stage Multiple System Atrophy (MSA)
- Trial name
- NCT05698017
- Testing
- hOMSC300
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Cytora Ltd.
Chronical Kidney Disease, Hypotension
Prediction of Risk of Hypotension in Hemodialysis
The main objective is to establish a statistical predictive model of the risk of intradialytic hypotension during hemodialysis (HD) or hemodiafiltration (HDF) sessions based on the measurement of residual blood volume and excess…
- Conditions
- Chronical Kidney Disease, Hypotension, Residual Blood Volume, Hemodialysis
- Trial name
- IMHOTEP (NCT03350308)
- Testing
- hemodialysis
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypotension During Surgery
Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction
Adequate free flap perfusion during Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction surgery requires maintaining blood pressure above 100 mmHg and avoiding excessive fluid administration.
- Trial name
- GDFT DIEP-flap (NCT06080178)
- Testing
- Plasma-lyte (static group), Norepinephrine (static group), Plasma-lyte (dynamic group)
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Chronic Subdural Hematoma
Spinal CSF Leaks in Chronic Subdural Hematoma
Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8/100.000.
- Trial name
- SPICE (NCT06323434)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Freiburg
Intraoperative Hypotension
Advanced Cardiovascular Management in Major Non-cardiac Surgery.
This is a single center, randomised and controlled clinical triaI whose aim is to predict and treat in advance, intraoperative hypotension episodes.
- Trial name
- NCT07134530
- Testing
- HPI-driven intraoperative hemodynamic management strategy, GDT strategy
- Where
- Italy
- Volunteers
- 534 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Blood Pressure, Perioperative Hypotension
Continuous Norepinephrine Administration and Blood Pressure Stability During Anesthetic Induction
This is a randomized trial investigating whether continuous norepinephrine administration via an infusion pump - compared to manual bolus administration - increases blood pressure stability within the first 15 minutes of…
- Trial name
- NCT05997303
- Testing
- Continuous norepinephrine infusion via an infusion pump, Manual bolus norepinephrine administration
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Orthostatic Hypotension
Effective Volemia in Older Adults With Orthostatic Hypotension
Clinical and biological assessments of volemia are challenging in older patients as they are more likely to present non-typical signs.
- Trial name
- EVO (NCT05304806)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypotension,Controlled
Correlation Analysis of the Effects of Management Pressure Goals and Control Volume Goals in Patients in Spinal Surgery
The investigators study 160 patients undergoing spinal surgery.Participants will be randomly divided into study group and control group.The study group will receive controlled hypotension by nitroglycerin and be divided into 3…
- Trial name
- NCT03917004
- Testing
- Nitroglycerin
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Liang Bing
Orthostatic Hypotension, Idiopathic Parkinson Disease
Lundbeck TOMs Orthostatic Hypotension
Orthostatic hypotension (OH), which consists in a significant reduction in blood pressure levels upon standing from a seated position, may affect approximately one in three patients with Parkinson's disease (PD).
- Trial name
- NCT04510922
- Testing
- Droxidopa 100 MG [Northera]
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Alberto Espay, MD, MSc
Severty of Hpotention
Comparing Sitting Versus Lateral Position During Spinal Anesthesia on the Severity of Hypotension:
This study aimed to assess the effect of sitting and lateral positions on the severity of hypotension during the initiation of spinal anesthesia in elective cesarean section. There will be Sitting and Lateral groups in the study.
- Trial name
- NCT06149572
- Testing
- lateral position procedure, sitting position porocedure
- Where
- Ethiopia
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Wollo University
Anesthesia
Tricuapid Annular Plane Sistolic Excursion Before General Anesthesia Can Predict Hypotension After Induction
the investigators purpose is to predict hypotensive condition that can develop after general anesthesia induction by measuring the Tricuspid Annular Plane Systolic Movement (TAPSE), which is an echocardiographic parameter.
- Trial name
- (Tapse) (NCT04580030)
- Where
- Turkey (Türkiye)
- Volunteers
- 7 people
- Sponsor
- Bursa City Hospital
Spinal-induced Hypotension
Granisetron in Diabetic Parturients Decrease Spinal Induced Hypotension
Diabetic Parturients are exposed to intraoperative hypotension after spinal anesthesia and we proposed that intravenous Granisterone 1 mg will attenuate the hypotension occurred with spinal block during Cesarean sections.
- Trial name
- NCT03091881
- Testing
- Granisetron 0.1 MG/ML
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Suez Canal University
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Anesthesia, Pediatrics
Norepinephrine for Prevention of Intraoperative Hypotension in Infants Undergoing Kasai Portoenterostomy
This study aims to assess the efficacy and safety of prophylactic intraoperative norepinephrine infusion versus the standard technique on decreasing the incidence of intraoperative hypotension in infants undergoing Kasai…
- Conditions
- Anesthesia, Pediatrics, Biliary Atresia
- Trial name
- NCT05521152
- Testing
- Norepinephrine Bitartrate
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Kasr El Aini Hospital
Intra-dialytic Hypotension
Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients
Intra-dialytic hypotensive (IDH) events can be defined as an abrupt decline in blood pressure that cause symptoms and/or require an intervention. They are common, affecting up to one third of maintenance HD sessions.
- Trial name
- NCT02145260
- Testing
- Lower dialysate sodium (138 mmol/L; using Renasol hemodialysis concentrate), Higher dialysate sodium (142 mmol/L; using Renasol hemodialysis concentrate)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Brigham and Women's Hospital
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