Clinical trials: Arterial Hypotension
Hypotension, Ischemia Reperfusion Injury
Intermittent Portal and Graft Purge in Living Donor Liver Transplantation
Post-reperfusion syndrome and ischemia-reperfusion insult are a common well-known complication in liver transplantation. Several trials investigated variables that my contribute to the generation of these two complications for…
- Trial name
- IPLDLT (NCT02845154)
- Testing
- bolus purge, Intermittent purge
- Where
- 3 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Hypotension During Surgery
Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy
This study is a randomized controlled trial designed to investigate the effects of two anesthetics, remimazolam and propofol, on intraoperative hemodynamics in patients undergoing laparoscopic liver resection.
- Trial name
- NCT06714669
- Testing
- propofol, Remimazolam
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Sun Yat-sen University
Hypotension, Controlled, Anaesthesia, Spinal
Non Invasive Haemodynamics in Neuraxial Anaesthesia Hypotension
Spinal (or neuraxial) anaesthesia is still considered the first choice technique for elective Caesarean section as simple, quick, reliable and cheap.
- Conditions
- Hypotension, Controlled, Anaesthesia, Spinal, Caesarean Section
- Trial name
- NIHNAH (NCT03653442)
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Papa Giovanni XXIII Hospital
Hypotension and Shock
Physiological Validation of Current Machine Learning Models for Hemodynamic Instability in Humans
This study will be collecting data on participants undergoing lower body negative pressure (LBNP) to simulate progressive blood loss.
- Trial name
- NCT03927066
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Intradialytic Hypotension, End-stage Renal Disease (ESRD)
Epidemiology And Risk Factors Of Intradialytic Hypotension In Maintenance Hemodialysis Patients
This prospective, multicenter observational study aims to describe how often intradialytic hypotension (IDH) occurs and to identify its risk factors in adult patients receiving maintenance hemodialysis.
- Conditions
- Intradialytic Hypotension, End-stage Renal Disease (ESRD), Chronic Kidney Failure, Chronic Kidney Disease, Stage IV (Severe)
- Trial name
- IDH-MHD (NCT07545629)
- Where
- China
- Volunteers
- 395 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Acute Kidney Injury, Chronic Kidney Disease Stage 5 on Dialysis
Non-invasive Assessment to Predict Tolerance to Fluid Removal on Intermittent Kidney Replacement Therapy
This prospective cohort study aim to investigate the ability of multiple types of assessments including 1) the modified Venous Excess Ultrasound (VExUS) assessment, 2) non-invasive estimation of absolute blood volume (ABV), and…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease Stage 5 on Dialysis, Chronic Kidney Failure, Intradialytic Hypotension
- Trial name
- TECHNO-HDF (NCT05270759)
- Testing
- Estimated absolute blood volume, Modified VExUS evaluation
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Spinal Cord Injuries
Diet and Exercise Solutions to Postprandial Hypotension
The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.
- Trial name
- NCT06882460
- Testing
- Low glycemic load, Electrical stimulation exercise, High glycemic load diet
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ohio State University
Postspinal Hypotension, Cesarean Birth
The Role of Preoperative Internal Jugular Vein Collapsibility and Perfusion Index in Predicting Hypotension After Spinal Anesthesia in Elective Cesarean Sections: A Prospective Observational Study
Spinal anesthesia is widely preferred for elective cesarean delivery due to its favorable safety profile and superior postoperative analgesia.
- Trial name
- NCT07539896
- Testing
- Baseline PI will be recorded,IJV diameters will be measured via ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Spinal Anesthesia Induced Hypotension
The Ability of Perfusion Index and Positional Perfusion Index Variation to Predict Spinal Anesthesia-induced Hypotension in Elderly Patients
In this study, we will test the ability of positional perfusion index variation to predict post-spinal anesthesia hypotension in elderly patients.
- Trial name
- NCT05259124
- Testing
- positional perfusion index variation
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Pruritis, Hypotension Drug-Induced
Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.
The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women.
- Conditions
- Pruritis, Hypotension Drug-Induced, Urinary Retention, Fetal Bradycardia During Labor
- Trial name
- NCT07187427
- Testing
- Spinal analgesia, Epidural Analgesia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Justine's Hospital
Anesthesia
Study of Use of Dexmedetomidine for Regional Anesthesia
The purpose of this study is to find out the proper amount of a drug called dexmedetomidine added to the local anesthetic drug called lidocaine to prolong the time and effect of pain relief provided for surgery.
- Trial name
- NCT01969903
- Testing
- Precedex injection
- Sponsor
- NYU Langone Health
Sepsis
Study of Treatment's Echocardiographic Mechanisms
This ancillary study determines whether the Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) [ClinicalTrials.gov Identifier: NCT03434028] treatment arms (restrictive fluids strategy vs.
- Trial name
- NCT03913403
- Testing
- ECHO, Blood Draw
- Where
- 7 sites in United States
- Volunteers
- 210 people
- Sponsor
- Intermountain Health Care, Inc.
Orthostatic Hypotension
Evaluation of the Contribution of Lower Limb and/or Abdominal Compression on Orthostatic Hypotension
Orthostatic hypotension (OH) is associated with an increased risk of myocardial infarction, stroke, heart failure and neurocognitive disorders. In the elderly, OH is an independent predictor of falls and mortality.
- Trial name
- HYPOFLEX (NCT06694688)
- Testing
- the supine/standing postural change test
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Gérond'if
Spinal Cord Injuries, Autonomic Dysreflexia
Spinal Cord Stimulation and Autonomic Response in People With SCI.
Despite being studied less than half as frequently, autonomic dysfunction is a greater priority than walking again in spinal cord injury.
- Conditions
- Spinal Cord Injuries, Autonomic Dysreflexia, Orthostatic Hypotension, Dysautonomic
- Trial name
- NCT03924388
- Testing
- Epidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation.
- Where
- 2 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Hypotension, Pregnancy Related
Non-invasive Haemodynamic Monitoring to Predict Spinal Hypotension During Caesarian Section
Spinal anaesthesia for elective caesarean section is associated with maternal hypotension, secondary to alteration of sympathetic tone and hypovolemia, in up to 70% of cases.
- Conditions
- Hypotension, Pregnancy Related, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
- Trial name
- NCT04608227
- Testing
- Clearsight monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospital Nord
Cardiovascular Disease, Surgery
Redesigning Cardiac Surgery to Reduce Neurologic Injury
Neurologic injuries are frequent and devastating complications following cardiac surgery. Previous work conducted by our research group and others has identified the principal mechanisms creating both overt and subtle neurologic…
- Trial name
- NCT00432536
- Testing
- Quality improvement intervention
- Where
- 3 sites in United States
- Volunteers
- 469 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hypotension
Predicting Hypotension Related to Spinal Anesthesia
This study aims to identify women at risk of low blood pressure (hypotension) after the usual cesarean anesthetic - a spinal anesthetic. Hypotension may be caused by dehydration.
- Trial name
- NCT01279889
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
the Severity and Duration of Intraoperative Hypotension
HPI in Older Patients Undergoing Major Gastrointestinal Surgery
The incidence of intraoperative hypotension was 91%. The increasing incidence of intraoperative hypotension would increase the risk of postoperative complications, such as postoperative arrythmia, stroke or acute kidney injury.
- Trial name
- NCT05297318
- Testing
- hypotension prediction index guided, without hypotesion prediction index guided
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Intraoperative Hypotension, Acute Kidney Injury
Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension
In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS.
- Conditions
- Intraoperative Hypotension, Acute Kidney Injury, Myocardial Injury After Non-cardiac Surgery
- Trial name
- Clearsight (NCT06291714)
- Testing
- GDT-based hemodynamic management based on Clearsight device
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Giessen
Post-spinal Hypotension
Variability of Perfusion Index to Predict Hypotension
About one-third of deliveries are performed by cesarean section, and this rate is increasing. The standard anesthetic technique for this procedure is spinal anesthesia (SA), which is associated with hypotension in nearly 70% of…
- Trial name
- IP-HYPO (NCT06769750)
- Testing
- leg-lift maneuver
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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