Clinical trials: Arterial Hypotension
Hypotension on Induction
Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
The primary endpoint is the effect of the addition of oral Diltiazem and Tranexamic Acid to general anesthesia aided reduction in blood loss during functional endoscopic sinus surgery (FESS).
- Trial name
- NCT03580590
- Testing
- oral Diltiazem, IV Tranexamic Acid
- Volunteers
- 40 people
- Sponsor
- Assiut University
Symptomatic Neurogenic Orthostatic Hypotension
Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
A Phase 3, multi-center, open-label study to evaluate the safety and tolerability of ampreloxetine in subjects with primary autonomic failures (MSA, PD, and PAF) and symptomatic nOH over 182 weeks.
- Trial name
- OAK (NCT04095793)
- Testing
- ampreloxetine
- Where
- 55 sites in United States, Australia and 16 more
- Volunteers
- 110 people
- Sponsor
- Theravance Biopharma
Spinal Induced Hypotension
Ephedrine Versus Ondansetron During Cesarean Delivery
More than 30% of the patients receiving spinal anesthesia develop hypotension. Hypotension developed during cesarean section (C/S) under spinal anesthesia may jeopardize uteroplacental circulation leading to fetal compromise and…
- Trial name
- NCT05127876
- Testing
- Ondansetron 4 MG, Ondansetron 8mg, EPHEDrine 10 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ain Shams University
Intraoperative Arterial Hypotension, Infant, Newborn
Determination of the Optimal Dose of Ephedrine in Intraoperative Arterial Hypotension of Newborns and Infants up to 6 Months of Age.
The incidence of arterial hypotension under general anesthesia using sevoflurane is particularly high in newborns and infants up to 6 months of age.
- Trial name
- EPHEDRINE (NCT02384876)
- Testing
- Ephedrine 30mg/10mL injectable solution, single administration, dose : 0.6, 0.8, 1.0, 1.2 and 1.4 mg/kG, Ephedrine 30mg/10mL injectable solution, single administration, dose : 0.1 mg/kG.
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer
Pneumatic Compression and Post-induction Hypotension
The purpose of this study is to evaluate the effect of pneumatic compression on post-induction hypotension in elderly patients undergoing robot assisted laparoscopic prostatectomy.
- Trial name
- NCT05343689
- Testing
- Pneumatic compression
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Ultrasound Guidance
Clinical Study of Combined Carotid Artery With Inferior Vena Cava Ultrasonography to Predict Hypotension After Induction of General Anesthesia
Studies have shown that the clinical application of ultrasound to measure large blood vessels related parameters has been widely used to assess the blood volume status of patients, with the advantages of simple, non-invasive and…
- Trial name
- NCT05472025
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Tongji Hospital
Post-induction Hypotension (PIH), Gynecologic Oncology Patient
Carotid Doppler Parameters and Post-Induction Hypotension
Post-induction hypotension is a common complication following the induction of general anesthesia and is associated with adverse postoperative outcomes.
- Conditions
- Post-induction Hypotension (PIH), Gynecologic Oncology Patient, Ultrasonography, Doppler
- Trial name
- CDUS-PIH (NCT07385274)
- Testing
- pre- induction carotid doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Ankara City Hospital Bilkent
Ephedrine, Norepinephrine
Intermittent Bolus Doses of Phenylephrine, Norepinephrine and Ephedrine for the Management of Spinal Induced Hypotension in Preeclamptic Patients
intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients
- Trial name
- NCT07795710
- Testing
- Group 1 (P), Group 2( N), Group 3( E)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Spinal Cord Injuries, Autonomic Imbalance
Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes
This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation.
- Conditions
- Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic; Hypotension, Neurogenic
- Trial name
- NCT04858178
- Testing
- Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis
Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders
The goal of this study is to use ultra-high-resolution (UHR) PET imaging to better understand how the brain and spinal cord change in healthy aging and in neurological and psychiatric disorders such as Alzheimer's disease (AD)…
- Conditions
- Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT07509125
- Testing
- UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease, Neurogenic Orthostatic Hypotension
Brain Perfusion & Oxygenation in Parkinson's Disease With NOH
This is a double blind placebo controlled trial in Parkinson's disease (PD) patients with neurogenic orthostatic hypotension (NOH).
- Trial name
- NCT03229174
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- William Ondo, MD
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Hypertension, Hypoxia
The VISION-Acute Study
AIM: We propose an innovative approach using Lifelight® smart technology that will enable the continued provision of high level patient care at the same time as reducing pressure on nursing and equipment resources.
- Conditions
- Hypertension, Hypoxia, Hypotension
- Trial name
- NCT04589923
- Testing
- Lifelight® Data Collect Blood Pressure Group, Lifelight® Data Collect Oxygen Saturation Group
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Xim Limited
Hypotension, Critical Illness
Midodrine for the Treatment of Refractory Hypotension
We hypothesize that midodrine treatment of refractory hypotension in patients otherwise ready for discharge from the ICU shortens duration of receiving IV vasopressors and SICU length of stay without increasing MGH length of stay…
- Trial name
- NCT01531959
- Testing
- Midodrine
- Where
- 3 sites in United States, Australia
- Volunteers
- 139 people
- Sponsor
- Massachusetts General Hospital
Orthopedic Surgery of Lower Limb
Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia
Lower limb orthopedic surgery is commonly realized under spinal anesthesia. This loco-regional anesthesia induces a peripheral vascular resistance decrease by vasodilatation resulting in hypotension.
- Trial name
- PPSA (NCT01533662)
- Testing
- phenylephrine infusion, patients receiving saline infusion
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Toulouse
Spinal Cord Injuries, Autonomic Dysreflexia
Spinal Cord Stimulation and Autonomic Response in People With SCI.
Despite being studied less than half as frequently, autonomic dysfunction is a greater priority than walking again in spinal cord injury.
- Conditions
- Spinal Cord Injuries, Autonomic Dysreflexia, Orthostatic Hypotension, Dysautonomic
- Trial name
- NCT03924388
- Testing
- Epidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation.
- Where
- 2 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Hypotension on Induction, Old Age
Effect of Trendelenburg Positioning on Anesthesia-Induced Hypotension in Elderly Patients
This study investigated the effect of Trendelenburg position on preventing post-induction hypotension in elderly patients undergoing abdominal surgery with general anesthesia.
- Trial name
- NCT06968091
- Testing
- Trendelenburg position, Supine Horizontal Position
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Zhejiang Cancer Hospital
Hypotension of Hemodialysis, Hypotension
Measuring Cardiovascular Stress in Patients on Hemodialysis Study II
The overall goal is to evaluate the predictive accuracy of a measure of autoregulatory adequacy derived from CVInsight and compare it with other measures in recognizing hypotensive events during hemodialysis..
- Conditions
- Hypotension of Hemodialysis, Hypotension, Estimated Dry Weight, Myocardial Injury
- Trial name
- NCT02182089
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Intelomed, Inc.
Hypotension, Kidney Injury
Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
The purpose of this study is to conduct a prospective, randomized, controlled trial comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients.
- Trial name
- NCT02135146
- Testing
- Plasmalyte 3ml/kg/hr group, Plasmalyte 6ml/kg/hr group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Anesthesia
Effect of Acupoint Electrical Stimulation on Incidence of Hypotension After Spinal Anesthesia
This study is intended to include elderly patients who are selected to undergo lower limb and pelvic orthopedic surgery under spinal anesthesia.
- Trial name
- NCT05716399
- Testing
- Transcutaneous electric stimulation pretreatment, Transcutaneous acupoint electrical stimulation treatment, Transcutaneous acupoint pseudo electric stimulation
- Volunteers
- 111 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
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