Clinical trials: Arterial Hypotension
Spinal Induced Hypotension in Cesarean Delivery
Up-Down Determination of the ED90 of Phenylephrine for Hypotension Prophylaxis in Cesarean Delivery
This study is designed to determine the ED90 for an infusion of phenylephrine to prevent spinal induced low blood pressure in parturients presenting for an elective cesarean delivery.
- Trial name
- NCT00796328
- Testing
- Phenylephrine infusion
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Shock
Extension of the RUSH Protocol for Volume Responsiveness
The current study plants to create a patient registry of patients who present to the emergency department with signs and symptoms of shock and evaluate the ability of a multi-step cardiopulmonary ultrasound protocol to determine…
- Trial name
- NCT03285269
- Testing
- Ultrasound Protocol, Bioreactance, Passive Leg Raise
- Sponsor
- Kaiser Permanente
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Autonomic Failure, Pure Autonomic Failure
CPAP for the Treatment of Supine Hypertension
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT05489575
- Testing
- Active CPAP, Sleeping in a head-up tilt (HUT) position
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Intraoperative Hypotension, General Anesthesia
Deep Learning Models for Prediction of Intraoperative Hypotension Using Non-invasive Parameters
The investigators aimed to investigate the deep learning model to predict intraoperative hypotension using non-invasive monitoring parameters.
- Trial name
- NCT05762237
- Where
- South Korea
- Volunteers
- 5,175 people
- Sponsor
- Samsung Medical Center
Phenylephrine, Cesarean Birth
Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect
Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to…
- Trial name
- NCT07420127
- Testing
- Phenylephrine bolus 75 micrograms, Phenylephrine bolus 50 micrograms
- Where
- Pakistan
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Type 2 Diabetes, Postprandial Hypotension
Acarbose, Postprandial Hypotension and Type 2 Diabetes
Postprandial hypotension carries a risk of significant morbidity and morbidity including syncope, falls, dizziness, fatigue, stroke and myocardial infarction.
- Trial name
- NCT02043886
- Testing
- Acarbose
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Post-spinal Anesthesia Hypotension
Ultrasonographic Evaluation of Internal Jugular Vein Cross Sectional Area for Prediction of Post Spinal Hypotension
The aim of this study is to evaluate the efficacy of internal jugular cross sectional area for predicting the occurrence of PSAH.
- Trial name
- NCT04780139
- Testing
- Ultrasonographic Evaluation of Internal Jugular Vein Cross Sectional Area
- Where
- Egypt
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia; Adverse Effect, Spinal and Epidural, Hypotension
Ephedrine vs. Nor Epinephrine Infusion in Preventing Hypotension After Spinal Anesthesia for Cesarean Section
The purpose of the study is to determine if norepinephrine is more effective as a continuous intravenous (IV) infusion compared to continuous IV ephedrine associated with crystalloid loading for maintaining blood pressure during…
- Conditions
- Anesthesia; Adverse Effect, Spinal and Epidural, Hypotension, Complications; Cesarean Section
- Trial name
- NCT02477501
- Testing
- Norepinephrine, Ephedrine
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Anesthesia
Prediction of Hypotension During Induction of General Anesthesia
Post induction hypotension is closely related to postoperative complications. Patients are at high risk of hypotension due to preexisting hypovolemia and the vasodilatory effects of induction agents.
- Trial name
- NCT06078228
- Testing
- Propofol - Fentanyl- Atracurium
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypotension, Orthostatic, Hypertension
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
Neurogenic Orthostatic Hypotension (NOH) is clinically defined as a consistent drop in systolic blood pressure (SBP) ≥30mmHg upon standing from a seated or lying position.
- Conditions
- Hypotension, Orthostatic, Hypertension, Autonomic Nervous System Diseases
- Trial name
- NCT02963181
- Testing
- Yohimbine, Melatonin
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
ESRD, Hemodialysis Complication
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis
For patients with kidney failure requiring hemodialysis treatment, sometimes the blood pressure will drop too low during dialysis.
- Conditions
- ESRD, Hemodialysis Complication, Blood Pressure
- Trial name
- TAKE-HOLD (NCT03327909)
- Testing
- TAKE vs. HOLD
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Stanford University
Adverse Effect
90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment
The objective of this study is to investigate the 90% effective dose of norepinephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment during cesarean section
- Trial name
- NCT06151509
- Testing
- Alpha-Agonist, α-adrenergic receptor agonist
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Pregnancy, Cesarean Section
Different Approaches to Maternal Hypotension During Cesarean Section
The aim of this study is to compare two different therapeutic approaches to blood pressure reduction: pharmacological vs. non-pharmacological.
- Conditions
- Pregnancy, Cesarean Section, Anesthesia,Spinal, Hypotension
- Trial name
- NCT00991627
- Testing
- Bupivacaine, Morphine, Lactated Ringer's solution
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Parma
Hypotension, Pregnancy Related
Non-invasive Haemodynamic Monitoring to Predict Spinal Hypotension During Caesarian Section
Spinal anaesthesia for elective caesarean section is associated with maternal hypotension, secondary to alteration of sympathetic tone and hypovolemia, in up to 70% of cases.
- Conditions
- Hypotension, Pregnancy Related, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
- Trial name
- NCT04608227
- Testing
- Clearsight monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospital Nord
Caesarean Section
The Pleth Variability Index and Hypotension at Caesarean Under Spinal.
During a caesarean section the blood pressure is usually measured every few minutes and it may fall too quickly to be detected in a timely fashion by this intermittent means.
- Trial name
- NCT02285569
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Intradialytic Hypotension, Immersion
Head Out Water Immersion for Hemodynamic Stability During Dialysis
Immersion to the neck before and during hemodialysis session may increase intravascular volume, potentiate the ability to ultrafiltrate excess water, with less symptoms of shock, muscle crumps etc.
- Trial name
- NCT03057392
- Testing
- immersion
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Assaf-Harofeh Medical Center
Hypotension
Dynamic Arterial Elastance to Predict Postural Change Induced Hypotension
During general anesthesia, hypotension might occur during positional change. It is reported that hypotension after positional change from supine to prone is mainly caused by the decrease in preload.
- Trial name
- NCT04850092
- Testing
- Positional change from supine to prone
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Kangbuk Samsung Hospital
Orthostatic Hypotension, Reflex Syncope
Data Collection - Of Syncope Tilt Table Testing Study
To characterize the impact of orthostatic hypotension (OH) and reflex syncope on signals measured using a wearable cardiac monitor prototype device.
- Trial name
- COST3 (NCT03721393)
- Testing
- Wearable heart monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Fluid Hypovolemia, Cerebrospinal
Assessment of Ultrasonographic Measurement of Inferior Vena Cava Collapsibility Index in Prediction of Hypotension Associated With Tourniquet Release in Total Knee Replacement Surgeries Under Spinal Anesthesia
Administration of intravascular fluids is one of the methods to prevent SA-induced hypotension, but empirical intraoperative volume repletion carries the risk of fluid overload during elective surgery.
- Trial name
- NCT05076929
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
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