Clinical trials: Arterial Line
Hypotension
Evaluation of Novel Optical Smartphone Application for Blood Pressure Measurements in Critically Ill Patients
Evaluation of a novel mobile application designed to estimate blood pressure (systolic-diastolic and mean arterial pressure) based on collected optical signals on patient's finger treated in intensive care unit patients
- Trial name
- NCT04728477
- Testing
- OPti BP measurements
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Intrahepatic Cholangiocarcinoma
HAIC Combined With Cadonilimab and Regorafenib as 2nd-line Treatment for ICC
This study is a single-arm Phase II clinical trial aiming to evaluate the safety and efficacy of HAIC combined with Cadonilimab and Regorafenib as second-line treatment for unresectable intrahepatic cholangiocarcinoma.
- Trial name
- NCT06335927
- Testing
- HAIC-GEMOX+Cadonilimab+Regorafenib
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Fudan University
Colorectal Cancer, Liver Metastases
Serplulimab+Regorafenib +Hepatic Artery Bicarbonate Infusion in Patients With Colorectal Cancer and Liver Metastases
A single-center, single-arm, phase 2 trial of Serplulimab in combination with Regorafenib and hepatic artery bicarbonate infusion for third-line treatment in patients with colorectal cancer and liver metastases.
- Trial name
- NCT05894837
- Testing
- Serplulimab+Regorafenib, Hepatic Artery Bicarbonate Infusion
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Arterial Line
Smart-glasses During the US-guided Radial Arterial Catheterization in Pediatric Patients: a RCT
The primary objective of the study is to evaluate the effect of smart glasses (Head-mounted display Moverio BT-300 (Epson Inc., USA)) on the first-attempt success rate of radial artery cannulation in pediatric patients.
- Trial name
- NCT04329026
- Testing
- Smart glasses, Control
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Seoul National University Hospital
Arterial Line
Guidewire-assisted Radial A-line in Neonate and Infant
In neonate and infant, radial artery cannulation may be challenging and multiple attempts are required because of the small diameter.
- Trial name
- NCT03217019
- Testing
- Guidewire-assist, Direct
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Unrescetable Hepatocellular Carcinoma
HAIC Combined With Cadonilimab and Bevacizumab as First-line Therapy in Unresectable Hepatocellular Carcinoma
To evaluate the efficacy and safety of HAIC combined with Cadonilimab and bevacizumab as first-line therapy in Unresectable hepatocellular carcinoma
- Trial name
- NCT05821361
- Testing
- HAIC+Cadonilimab+Bevacizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Coronary Artery Disease, Bifurcation Lesion
Using 3D Imaging to Optimize Bifurcation Stenting
The primary purpose of this study is to determine whether bifurcation stenting guided by on-line three-dimensional optical frequency domain imaging (3D-OFDI) is superior to that with angiographic guidance by measuring incomplete…
- Trial name
- NCT02972489
- Testing
- 3D OFDI guidance arm, Angio guidance arm
- Where
- 2 sites in Japan, Netherlands
- Volunteers
- 106 people
- Sponsor
- Increase Co., Ltd.
Renal Failure, Hemodynamics
Hemodynamic Assessment APCO Monitor vs Crit Line for Renal Replacement Rx
Fluid and volume management are a challenging part of critical care and the difficulties increase in the face of renal failure. Utilizing the Crit-Line to monitor blood volume changes in conjunction with arterial pressure cardiac…
- Trial name
- APCOvC-Line (NCT00666003)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Adebrelimab (SHR-1316), Bevacizumab
Efficacy and Safety of Low-dose Bevacizumab Plus Adebrelimab Combined With Transarterial Chemoembolization Followed by Hepatic Arterial Infusion Chemotherapy (TACE-HAIC) as First-line Treatment for Unresectable Hepatocellular Carcinoma: A Single-arm Phase 2 Trial
his is a single-arm, phase II clinical study evaluating the efficacy and safety of low-dose bevacizumab (7.5 mg/kg, Q3W) plus adebrelimab (1200 mg, Q3W) combined with transarterial chemoembolization (TACE) followed by hepatic…
- Conditions
- Adebrelimab (SHR-1316), Bevacizumab, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07543783
- Testing
- Transarterial Chemoembolization (TACE), Hepatic Arterial Infusion Chemotherapy (HAIC, FOLFOX), Adebrelimab
- Volunteers
- 38 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Aortic Aneurysm, Aortic Aneurysm Abdominal
Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery
This clinical study aims to evaluate the effectiveness and safety of using NE'X Glue R-eco to seal suture lines. The adhesive will be applied to reduce the risk of suture line bleeding in cardiac or vascular repair surgeries, a…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm Abdominal, Valve Stenoses, Aortic, Valve Regurgitation, Mitral
- Trial name
- CLOSURE (NCT06918496)
- Testing
- Surgical placement of a prosthetic or biologic graft (patch), or an allograft for cardiac and (cardio)vascular repair.
- Where
- 2 sites in Belgium, Poland
- Volunteers
- 60 people
- Sponsor
- Grena Biomed Limited
Hepatocellular Carcinoma, Atezolizumab Plus Bevacizumab
Low-Dose Bevacizumab and Atezolizumab Combined With TACE-HAIC in Unresectable Hepatocellular Carcinoma
This is a prospective, single-arm, phase II clinical study designed to evaluate the efficacy and safety of low-dose bevacizumab plus atezolizumab combined with transarterial chemoembolization followed by hepatic arterial infusion…
- Conditions
- Hepatocellular Carcinoma, Atezolizumab Plus Bevacizumab, Transarterial Chemoembolization
- Trial name
- NCT07543510
- Testing
- TACE-HAIC + Atezolizumab + Low-dose Bevacizumab
- Volunteers
- 38 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Colon Cancer Liver Metastasis
Observational Study on Second Line Treatment of Liver Metastases With DEBIRI and Cetuximab
The recently introduced chemoembolization has been considered to be a very attractive new method in terms of response in the treatment of liver metastases from colon cancer carcinoma (LM-CRC).
- Trial name
- TACETUX (NCT01891552)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- International Group of Endovascular Oncology
Arterial Catheters, Catheter Related Complication
Skin Glue Versus Suture for Securing Radial Arterial Lines
Prior investigators have evaluated the use of 2-octyl cyanoacrylate (glue) as a method to secure a variety of venous catheters including central/peripheral lines.
- Trial name
- NCT06589284
- Testing
- Silk 0-0 suture covered by chlorhexidine gluconate dressing, 2-octyl cyanoacrylate covered by chlorhexidine gluconate dressing
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
SARS-CoV-2 ICU Bound
Arterial Line Patency in ICU Bound COVID-19 Patients
The health care system was completely overwhelmed by the SARS-Cov-2 virus, and ICU admissions soared as a result of the ICU doctors' increased workload.
- Trial name
- NCT04992221
- Testing
- arterial line
- Where
- Qatar
- Volunteers
- 245 people
- Sponsor
- Hamad Medical Corporation
Non-Small Cell Lung Cancer
The Efficacy and Safety of Drug Loaded Microsphere Bronchial Artery Chemoembolization (DEB-BACE) Combined With Anlotinib and Adebelimumab in the Third Line Treatment of Advanced NSCLC: a Prospective, Single Arm, Single Center, Exploratory Clinical Study
The goal of this clinical trial is to learn about Drug loaded microspheres for bronchial artery chemoembolization (DEB-BACE) combined with anlotinib and adebelimumab in patients with advanced NSCLC after second-line treatment.
- Trial name
- NCT06188650
- Testing
- Anlotinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Coronary Artery Disease
The Wire-free Invasive Functional Imaging (WIFI) Study
Quantitative Flow Ratio (QFR) is a new method for evaluating the functional significance of coronary stenosis by calculation of the pressure in the vessel based on two angiographic projections.
- Trial name
- WIFI (NCT02795585)
- Testing
- QFR (observational)
- Where
- Denmark
- Volunteers
- 99 people
- Sponsor
- Niels Ramsing Holm
Advanced Hepatocellular Carcinoma (HCC)
Safety and Efficacy of Paclitaxel Liposome Arterial Infusion Combined With Systemic Therapy for Second-Line Treatment of Advanced Liver Cancer
This trial is an open-label, dose-escalation, and randomized controlled Phase Ib/II clinical study for second-line treatment in participants with advanced hepatocellular carcinoma (HCC).
- Trial name
- NCT07282509
- Testing
- HA131, Enlonstobart Injection, Pembrolizumab Injection
- Volunteers
- 116 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Hepatocellular Carcinoma
Phase Ⅱ Study of HAIC of FOLFOX vs. Sorafenib in HCC Refractory to TACE
To evaluate safety and efficacy of combined hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, 5-fluorouracil and leucovorin and sorafenib in hepatocellular carcinoma (HCC) refractory to transarterial…
- Trial name
- NCT03722498
- Testing
- HAIC of FOLFOX, Sorafenib
- Where
- 3 sites in China
- Sponsor
- Sun Yat-sen University
Learning Development
Computer-Assisted Instruction: Arterial Blood Gases
This research work develops a diagnostic and feedback-providing system for self-learning by volunteers who are asked to log in to a website to study the required subjects in three weeks.
- Trial name
- CAI (NCT01627730)
- Testing
- pretest and posttest scores
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Unstable Blood Pressure, Hypotension
Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS
The goal of this study is to evaluate if a novel near-infrared spectroscopy (NIRS) device can accurately estimate blood pressure in newborns at risk for unstable blood pressure.
- Trial name
- NCT06994494
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital