Clinical trials: Arterial Occlusive Disease
Healthy Participants
A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With Obesity
The aim of this study is to evaluate the safety and tolerability, and pharmacodynamics (PD) of AZD4144 administered as repeated daily oral dosing.
- Trial name
- NCT06942923
- Testing
- AZD4144
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Age-related Macular Degeneration, Coronary Artery Disease
Ranibizumab and the Risk of Arterial Thromboembolic Events
The investigators assume that ranibizumab might be dangerous in patients with history of coronary artery disease or cerebrovascular events.
- Conditions
- Age-related Macular Degeneration, Coronary Artery Disease, Cerebrovascular Disorders
- Trial name
- RATE (NCT01319188)
- Testing
- 0.5 mg of ranibizumab, 0.5 mg of ranibizumab + photodynamic therapy
- Where
- 2 sites in Netherlands, Russia
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Ural State Medical University
Coronary Artery Disease
Genotype Information and Functional Testing Study
This study is a sub-study of GRAVITAS (clinicaltrials.gov identifier NCT00645918). The purpose of this study is to assess which genes influence residual platelet reactivity on standard dose clopidogrel therapy, and also to…
- Trial name
- GIFT (NCT00992420)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Scripps Health
Coronary Artery Disease, Mitral Valve Insufficiency
Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study
Ambulation following surgery has been found to be beneficial for patients; however, nurses and doctors struggle with getting post-operative, hospitalized patients to walk on their own.
- Conditions
- Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation
- Trial name
- NCT02375282
- Testing
- Ambulation orderly
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Baystate Medical Center
Peripheral Artery Disease
Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease
The investigators are doing this research study to find out if taking Metformin improves walking ability in patients with peripheral arterial disease (PAD).
- Trial name
- NCT01901224
- Testing
- Metformin 1000 mg
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease
Prophylactic Administration of Levosimendan in Patients Undergoing Coronary Surgery
The present pilot study aims to investigate the effectiveness of the preoperative infusion of levosimendan in patients with impaired left ventricular function undergoing coronary artery bypass grafting.
- Trial name
- NCT01318460
- Testing
- Levosimendan infusion
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- AHEPA University Hospital
Atherosclerotic Cardiovascular Disease, STEMI
Real Life Lipid Management in Hospitals Not Participating in PENELOPE Trial - Control Population for PENELOPE
Guideline recommended evidence-based clinical care correlates with improved patient outcomes. In real life care, however, adherence to guideline recommendations remains suboptimal.
- Conditions
- Atherosclerotic Cardiovascular Disease, STEMI, Non STEMI
- Trial name
- PENELOPECTRL (NCT05659888)
- Where
- 13 sites in Netherlands
- Volunteers
- 827 people
- Sponsor
- Clinical Operations WCN B.V.
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Obesity
Optimized Cardioprotection Therapy in Obese Subjects With CAD
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Obesity, Adiposis; Heart
- Trial name
- NCT04570527
- Testing
- PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
COVID-19 Pandemic, Dyspnea; Cardiac
Covid-19 Infection and Long-term Cardiovascular Symptoms
From the registry of professor Kojuri clinic , those with Covid-19 infection were selected and was contacted and asked about the cardiovascular symptoms, 1 year after the covid infection
- Conditions
- COVID-19 Pandemic, Dyspnea; Cardiac, Chest Syndrome, Functional Cardiac Disorder
- Trial name
- NCT05715879
- Testing
- covid infection, admission to hispital
- Where
- Iran
- Volunteers
- 879 people
- Sponsor
- Shiraz University of Medical Sciences
Peripheral Arterial Disease
A Prospective, Multicenter Atherectomy Study Showing Luminal Gain in Subjects With Peripheral Vascular Blockages
To evaluate the safety and effectiveness of the DABRA Laser System in the atherectomy of peripheral vascular stenoses.
- Trial name
- NCT04241224
- Testing
- Atherectomy
- Where
- 10 sites in United States
- Volunteers
- 108 people
- Sponsor
- Ra Medical Systems
Moyamoya Disease
Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia
Moyamoya disease is characterized by progressive stenosis of the genesis of the distal internal carotid arteries bilaterally and progressive generation of compensatory pathological vascular networks at the basis cranii, and these…
- Trial name
- NCT06041659
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Artery Disease, Smoking Cessation
PRISM-GENOMICS-Smoking Cessation for Patients With Coronary Artery Disease Undergoing Cardiac Catheterization or Having a Heart Attack at Barnes Hospital in St. Louis Mo
It has previously been shown that patients with coronary artery disease may have a harder time quitting smoking if they have a specific genetic profile and that these individuals have a better chance at quitting if they receive…
- Trial name
- NCT03383224
- Testing
- genotype-guided therapy, Nicotine patch, Smoking cessation counseling
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Atherosclerosis, Cardiovascular Diseases
Semaglutide and Vascular Regeneration
SEMA-VR is a prospective, randomized, 6-month long, open-label study of semaglutide. Approximately 100 participants with type 2 diabetes and/or obesity will be randomized (1:1) to receive semaglutide at escalating doses (up to…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity
- Trial name
- SEMA-VR (NCT05870462)
- Testing
- Semaglutide Pen Injector
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Ischemic Heart Disease, Atrial Fibrillation
Anticoagulation on Demand After Percutaneous Coronary Intervention in High Bleeding Risk Patients
Preliminary experiences suggest that intermittent anticoagulation guided by continuous electrocardiographic monitoring can reduce the incidence of bleeding in patients with episodes of atrial fibrillation.
- Trial name
- INTERMITTENT (NCT04151680)
- Testing
- Intermittent administration of dabigatran, rivaroxaban, apixaban, or edoxaban, Chronic administration of dabigatran, rivaroxaban, apixaban, or edoxaban
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Coronary Artery Disease
A Study of the Presillion Stent in de Novo Coronary Lesions
The PRESILLION Study is a non-randomized, multi-center, single-arm study evaluating the safety of an approved Cobalt Chromium bare metal stent system for the treatment of ischemic heart disease attributable to a stenotic de novo…
- Trial name
- PRESILLION (NCT00722579)
- Testing
- PRESILLION cobalt chromium stent
- Where
- Belgium
- Volunteers
- 101 people
- Sponsor
- Cordis US Corp.
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Atherosclerosis, Cardiovascular Diseases
Progression of Sub-Clinical Atherosclerosis
To determine the rate of progression of sub-clinical cardiovascular disease as measured in carotid intimal medial thickness over a period of 8 to 10 years.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00241787
- Volunteers
- 2,900 people
- Sponsor
- Tufts Medical Center
Coronary Artery Disease
The Oxford Optimisation of PCI Study (OXOPT-PCI Study)
The OxOPT-PCI study addresses patients with coronary artery disease who are referred to the John Radcliffe Hospital because of the need for treatment with an intra-coronary stent (metal scaffold) for clinical reasons.
- Trial name
- OXOPT-PCI (NCT03111940)
- Testing
- Optimisation of the result of intracoronary stenting according to specific algorithm
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Oxford University Hospitals NHS Trust
Arterial Disease, Surgery
Measuring the ACT During Non-cardiac Arterial Procedures.
Aim of the MANCO study is to establish for once and for all that monitoring the effect of heparin during NCVI (Non-Cardiac Vascular Interventions) is essential to ensure the individual patient of safe and tailor-made…
- Conditions
- Arterial Disease, Surgery, PTA, Peripheral Arterial Disease
- Trial name
- MANCO (NCT03426293)
- Testing
- Measuring the ACT to determine effect of heparin
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Dijklander Ziekenhuis
Peripheral Artery Disease
Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2
The purpose of this study is to monitor changes in local tissue oxygen levels in participants with Peripheral Artery Disease (PAD) using the Wireless Lumee Oxygen Platform.
- Trial name
- NCT04514861
- Testing
- Wireless Lumee Oxygen Platform
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Profusa, Inc.
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.