Clinical trials: Arterial Occlusive Diseases
Coronary Artery Disease
Influence of Extracorporeal Circulation on the Development of OSA (Obstructive Sleep Apnea)
1. Coronary artery bypass grafting (CABG) could be performed with or without extracorporeal circulation (ECC). 2. OSA (Obstructive Sleep Apnea) could be influenced by in intravenous perfusion. 3.
- Trial name
- NCT03743090
- Testing
- Polysomnography.
- Sponsor
- Astes
Dementia, Dementia, Vascular
Feasibility of the SmartPrompt for Improving Everyday Function in Dementia
Difficulty completing everyday tasks is a primary reason for the high cost of care, loss of caregiver paid hours, and general caregiver burden associated with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia Alzheimers, Dementia, Mixed
- Trial name
- SmartPrompt (NCT04313582)
- Testing
- SmartPrompt smartphone application
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Temple University
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant
The purpose of this study is to determine if bempedoic acid (ETC-1002) is effective and safe versus placebo in patients with elevated LDL cholesterol and who are statin-intolerant.
- Conditions
- Hypercholesterolemia, Atherosclerotic Cardiovascular Disease, Statin Adverse Reaction
- Trial name
- CLEAR Serenity (NCT02988115)
- Testing
- bempedoic acid
- Where
- 67 sites in United States, Canada
- Volunteers
- 345 people
- Sponsor
- Esperion Therapeutics, Inc.
Coronary Artery Disease, End Stage Renal Disease
Prospective Study of End Stage Renal Disease Patients With Coronary Artery Disease Treated by Oral Nicorandil
Nicorandil is potentially effective to prevent cardiovascular events in patients with coronary artery disease (CAD) receiving hemodialysis.
- Trial name
- NCT01475123
- Testing
- Nicorandil
- Where
- Japan
- Volunteers
- 268 people
- Sponsor
- Kumamoto University
Coronary Artery Disease
NAVIGATE GRX Study
The objective of the present study is to detail the results of robotic-assisted PCI using technIQ automated movements in real-world clinical practice.
- Trial name
- NCT04883008
- Testing
- CorPath GRX with technIQ automated movements enabled (technIQ ON), CorPath GRX with technIQ automated movements disabled (technIQ OFF).
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
Coronary Artery Disease, Coronary Stenosis
TARGET-PREMIER Trail in Evaluating the Safety and Efficacy of the Rapamycin Target Eluting Stent in CAS Treatment
The aim of the TARGET PREMIER trail in to demonstrate the safety and efficacy of the rapamycin target eluting stent in the treatment of subjects with ischemic heart disease (asymptomatic myocardial ischemia , table or unstable…
- Trial name
- T-P (NCT04951050)
- Testing
- Rapamycin target eluting stent
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Coronary Artery Disease, Atrial Fibrillation New Onset
Predictors of Postoperative Atrial Fibrillation After CABG
This observational study aims to identify the determinants or predictors of postoperative atrial fibrillation (POAF) in patients who have undergone coronary artery bypass grafting (CABG).
- Trial name
- CODA-AF (NCT05888168)
- Testing
- CABG
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Kun Hua
Peripheral Artery Disease
Effects of Prolonged DAPT After Lower Extremity Percutaneous Transluminal Angioplasty (PTA) in Patients With LE-PAD
The objective of the present study was to evaluate the prognostic impact of prolonged dual antiplatelet therapy (DAPT) with acetylsalicylic acid plus clopidogrel on the incidence of major adverse cardiovascular events and major…
- Trial name
- LONGDAPTPAD (NCT02798913)
- Testing
- Short DAPT, Long DAPT
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Medium Vessel Occlusion, Ischemic Stroke, Acute
Intra-arterial Thrombolysis For Acute Ischemic Stroke With Medium Vessel Occlusion
A multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) phase III trial is planned to evaluate the efficacy and safety of intra-arterial thrombolysis (IAT) in patients with acute ischemic stroke caused by…
- Trial name
- IAT-MEVO (NCT07668323)
- Testing
- Recombinant Tissue Plasminogen Activator (rt-PA), Intra-arterial Thrombolysis, Best Medical Management
- Where
- China
- Volunteers
- 372 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Coronary Artery Disease
Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients
Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54).
- Trial name
- ONEEF (NCT01030367)
- Testing
- PETN, ISDN
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Julius-Maximilians University
Myocardial Infarction, Diabetes Mellitus
Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor, more frequently clopidogrel, represents the standard of care for the long-term secondary prevention of atherothrombotic events in patients with…
- Conditions
- Myocardial Infarction, Diabetes Mellitus, Peripheral Arterial Disease
- Trial name
- OPTIMUS-5 (NCT02548650)
- Testing
- Vorapaxar, Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Florida
Atherosclerosis
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study
It has been argued that social relationships are important to health and well-being. This study will investigate links between social networks and cardiovascular disease risk factors in South Asians, the second fastest growing…
- Trial name
- NCT02268513
- Where
- 2 sites in United States
- Volunteers
- 775 people
- Sponsor
- Northwestern University
Cancers, Atheroscleroses, Coronary
The Sakakibara Health Integrative Profile of Atherosclerotic-Carcinogenesis Hypothesis (SHIP-AC)
As previously reported (IJC Heart \& Vasculature 2017; 17: 11.), our epidemiological analysis showing high incidence of cancers in patients with atherosclerotic cardiovascular diseases as compared with those with…
- Conditions
- Cancers, Atheroscleroses, Coronary, Atherosclerosis of Artery
- Trial name
- SHIP-AC (NCT04198896)
- Testing
- incidece of cancers
- Volunteers
- 8,856 people
- Sponsor
- Sakakibara Heart Institute
Peripheral Artery Disease
Exercise Testing in Peripheral Artery Disease Patients
The aim of this study was to evaluate exercise testing in case of patients suspected of Peripheral Artery Disease (PAD).
- Trial name
- ExercisePAD (NCT03186391)
- Testing
- Data collected
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Rennes University Hospital
Ischaemic Heart Disease, Contrast-induced Nephropathy
Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients
A large number of patients with symptomatic ischaemic heart disease undergo coronary artery bypass grafting (CABG) to alleviate their symptoms and improve prognosis.
- Trial name
- BYPASS-CTCA (NCT03736018)
- Testing
- CTCA
- Where
- United Kingdom
- Volunteers
- 688 people
- Sponsor
- Queen Mary University of London
Coronary Artery Disease
One-Dimensional Mathematical Model-Based Automated Assessment of Fractional Flow Reserve
This study evaluates the diagnostic efficiency of an automated method of noninvasive assessment of the fractional reserve of coronary blood flow.
- Trial name
- NCT03797118
- Testing
- FFR
- Where
- Russia
- Volunteers
- 31 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Anticoagulant Drugs, Antiplatelet Drug
Effect of Anticoagulant Drug Intervention on Postoperative MALE and MACE in Patients With PAD
Patients with PAD were grouped according to the combination of different anticoagulant and antiplate drugs. The type, dosage and duration of anticoagulant and antiplatelet drugs were recorded after operation.
- Conditions
- Anticoagulant Drugs, Antiplatelet Drug, Peripheral Arterial Disease
- Trial name
- NCT05852197
- Testing
- anticoagulant or antiplatelet drugs
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Coronary Artery Disease, Acute Coronary Syndromes
Discovery of New Circulating Biomarkers of Coronary Atherosclerosis
The study hypothesis is that differential proteomic techniques can be used to discover new circulating biomarkers of coronary atherosclerosis in the blood of patients suffering from coronary artery disease (either stable or…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Myocardial Infarction, Atherosclerosis
- Trial name
- NCT00430820
- Testing
- per intervention
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke From Large Vessel Occlusion
The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Albumin-assisted therapy has demonstrated good safety and potential neuroprotective effects following mechanical thrombectomy. To further systematically evaluate its efficacy and safety, we are conducting a Phase IIa clinical…
- Trial name
- NCT07294391
- Testing
- Human serum albumin infusion 20%
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Atherosclerosis, Coronary
Fluid-dynamics in Bifurcation PCI
Investigator-initiated, international, multicentre, observational study with two cohorts. The two study cohorts will be: Cohort A: to understand if the local blood flow patterns (associated with low WSS), as evaluated by…
- Trial name
- FORECAST (NCT03174418)
- Testing
- Coronary angiography and optical coherence tomography
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Catholic University of the Sacred Heart
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