Clinical trials: Arterial Occlusive Diseases
Hypertension, Hypercholesterolemia
Effects of Purple Vegetables on Cardiovascular Disease (CVD) Risk Factors
The hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods.
- Conditions
- Hypertension, Hypercholesterolemia, Type II Diabetes, Obesity
- Trial name
- NCT01564498
- Testing
- vegetable
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Guelph
Coronary Artery Disease
Jailed-balloon Technique in Coronary Bifurcation Lesion PCI
This study aims to test the hypothesis that jailed-balloon technique(JBT) is superior to jailed-wire technique(JWT) in non-left main coronary bifurcation percutaneous coronary intervention(PCI) by lowering the risk of side…
- Trial name
- JBTinCBL (NCT02167230)
- Testing
- Jailed-balloon technique, Jailed-wire technique
- Where
- 2 sites in China
- Volunteers
- 410 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Total Occlusion of Coronary Artery
REduction of Contrast Via DyeVert Used in CTO Procedures
The is an observational, prospective study to evaluate the effect of the DyeVert System on contrast volume administration in patients undergoing clinically-indicated chronic total occlusion (CTO) percutaneous coronary…
- Trial name
- REDUCe (NCT03118544)
- Testing
- DyeVert System
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Minneapolis Heart Institute Foundation
Peripheral Artery Disease (PAD)
Safety and Effectiveness of the Peripheral Balloon-Expandable Covered Stent System for Iliac Artery Stenosis/Occlusion. (SELECT)
This is a prospective, multi-center, single-arm clinical trial to evaluate the Peripheral Balloon-Expandable Covered Stent System for treating stenosis and/or occlusion in the common and external iliac arteries.
- Trial name
- SELECT (NCT06605209)
- Testing
- Peripheral Balloon-Expandable Covered Stent System
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Coronary Artery Disease, Radial Artery Occlusion
A Study on the Application of Simple and Improved Radial Artery Compression Method After Transradial Coronary Intervention
The objective of this study was to evaluate the specific effect of a simple modified method of thick gauze (9cm*16cm*8mm) combined with a hemostatic device in the prevention of early radial artery occlusion and other related…
- Trial name
- NCT06787287
- Testing
- Modified compression method
- Where
- China
- Volunteers
- 1,624 people
- Sponsor
- Guozhe Sun
Atherosclerosis, Coronary Heart Disease
Alirocumab and Reverse Cholesterol Transport
Alirocumab is an injectable treatment for elevated blood cholesterol. The hypothesis of this study is that it also increases cholesterol excretion from the body into the stool, a process sometimes called reverse cholesterol…
- Trial name
- NCT03014830
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Peripheral Artery Disease
Effects of Message Content on Intention to Quit Smoking
Message framing involves "the presentation of choice alternatives, either in a positive or negative manner" (Huber, Neale, \& Northcraft, 1987; p.137).
- Trial name
- NCT02138032
- Testing
- Gains Framed Message, Loss Framed Message
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Stirling
Critical Limb Ischemia
Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With No-option Critical Limb Ischemia (N-O CLI)
The main objective of the CIRCULATE project is to compare the clinical outcomes of CardioCell administration in treatment of ischemic damages of cardiovascular system with control group, who will be treated by the administration…
- Trial name
- NCT03423732
- Testing
- CardioCell
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- John Paul II Hospital, Krakow
Critical Limb Ischemia, Malnutrition
Nutrition in Patient With Critical Limb Ischemia
A prospective pilot study examining nutritional supplements among vascular surgery patients with Critical Limb Ischemia (CLI). CLI patients have a high rate of malnutrition and has the potential to benefit greatly from…
- Conditions
- Critical Limb Ischemia, Malnutrition, Nutritional Supplements
- Trial name
- NutriVasc (NCT03529019)
- Testing
- Ensure Surgery Immunonutrition Shake, Ensure Enlive Advanced Nutrition Shake
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Medical Center
Atherosclerosis
Genetic Factors in Atherosclerosis
The purpose of this study is to identify genes associated with certain risk factors for atherosclerosis (hardening of the arteries) and its consequences, such as development of coronary artery disease, heart attack, other blood…
- Trial name
- NCT00359307
- Where
- United States
- Volunteers
- 1,888 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Artery Disease
Virtual Coronary Physiology: an Angiogram is All You Need
Disease in coronary arteries kills more people in the UK than any other cause. The investigators have developed a computer system ('VIRTU') which predicts blood pressure changes inside coronary arteries.
- Trial name
- NCT02437734
- Testing
- Percutaneous Coronary Intervention
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Coronary Artery Disease, Adherence
Using Feedback Reports to Improve Medication Adherence
The purpose of this research study is to improve statin medication adherence among Veterans with coronary artery disease with poor adherence to medications.
- Trial name
- NCT02480530
- Testing
- Individual Feedback, Feedback Friend
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Heart Failure
Coronary Artery Disease in Hearts Donated for Transplantation
In spite of recent initiatives, in particular, the introduction into clinical practice of donation after circulatory death (DCD), there is a persistent mismatch between the demand for donor hearts for transplantation and their…
- Trial name
- NCT06528834
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Diabetic Foot Ulcer
The Effect Of Fragmin In The Treatment Of Neuroischaemic Foot Ulcers In Diabetic Patients (A6301086)
The primary objective of this 6 month open-label extension trial is to evaluate long-term safety and tolerability of dalteparin in treatment of chronic neuroischaemic foot ulcers in diabetic patients with peripheral arterial…
- Trial name
- NCT00765063
- Testing
- Fragmin
- Where
- 27 sites in Austria, Belgium and 12 more
- Volunteers
- 62 people
- Sponsor
- Pfizer
Coronary Artery Disease
OPTImized Coronary Interventions eXplaIn the bEst cliNical outcomEs
Hypothesis: the clinical outcome of patients with indication of PCI and coronary stent implantation that are at high risk of events can be improved with a widespread use of intra-coronary tools that allow a PCI optimization (i.e.
- Trial name
- OPTI-XIENCE (NCT04674475)
- Testing
- Pressure guidewire, optimal coherence tomography
- Volunteers
- 1,000 people
- Sponsor
- Spanish Society of Cardiology
Stable Coronary Artery Disease (CAD), Myocardial Infarction
Aerobic Interval vs Continuous Training on Heart Rate-Power Decoupling in Ischemic Heart Disease
This study is a randomized, parallel-group clinical trial with assessor and statistical analyst blinding, conducted at a single center.
- Trial name
- NCT07485400
- Testing
- Intervention Group, Control Group (A):
- Volunteers
- 48 people
- Sponsor
- Universidad Complutense de Madrid
Smoking Cessation, Coronary Artery Disease
Cytisine Compared to Combination NRT in Relapsed Smokers
Cigarette smoking causes cardiovascular disease (CVD) yet many smokers with CVD are unable to quit despite strong desire to do so.
- Trial name
- CYTvsNRT+ (NCT04286295)
- Testing
- Cytisine, Nicoderm C-Q Transdermal Product, Nicorette Lozenge Product
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease
Effects of Exercise Training on Endothelial Function, Inflammation, Arterial Stiffness and Autonomic Function in CAD
The main purposes of this study is to analyze, in a randomized controlled trial, the effects of an exercise-based cardiac rehabilitation program (i) on biomarkers of endothelial function, (ii) on biomarkers of inflammation, (iii)…
- Trial name
- NCT01432639
- Testing
- Exercise-based cardiac rehabilitation program
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Universidade do Porto
Acute Ischemic Stroke From Large Vessel Occlusion
Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Stroke remains a predominant global public health challenge, ranking as the third leading cause of death and the fourth leading contributor to disability-adjusted life years (DALYs).
- Trial name
- AMASS2 (NCT07365475)
- Testing
- 20% human serum albumin
- Volunteers
- 306 people
- Sponsor
- Tianjin Huanhu Hospital
Peripheral Arterial Disease
BRAVO: Biomarker Risk Assessment in Vulnerable Outpatients
The investigators hypothesize that among people with lower extremity peripheral artery disease (PAD), biomarker levels are higher during time periods immediately preceding an acute coronary event compared to time periods not…
- Trial name
- BRAVO (NCT02276781)
- Where
- 6 sites in United States
- Volunteers
- 595 people
- Sponsor
- Northwestern University
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