Clinical trials: Arterial Occlusive Diseases
Diabetes Mellitus, Critical Limb Ischemia
N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
In this pilot clinical study the investigators propose to conduct a prospective, randomized, double-blinded, placebo-controlled clinical trial for 30 days for participants with critical limb ischemia (CLI) who undergo a major…
- Conditions
- Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
- Trial name
- NCT03253328
- Testing
- Active Arm N-acetyl cysteine (NAC)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease
Single-cell Multi-omics Analyses of OCT-diagnosed Plaque Subtypes in Coronary Artery Disease (MOOP-CAD)
The MOOP-CAD study program characterizes, for the first time, the pathophysiological processes and molecular mechanisms of coronary atherosclerotic plaque progression by combining in vivo intravascular imaging techniques with…
- Trial name
- MOOP-CAD (NCT06489119)
- Where
- 2 sites in China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Harbin Medical University
Stroke, Cerebral Infarction
Aspirin Or Warfarin To Prevent Stroke
The purpose of this study is to determine whether aspirin or warfarin is more effective in preventing stroke in patients with intracranial stenosis.
- Conditions
- Stroke, Cerebral Infarction, Atherosclerosis, Constriction, Pathologic
- Trial name
- NCT00004728
- Testing
- Warfarin, Aspirin
- Where
- United States
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Atherosclerosis, Type 2 Diabetes Mellitus
Omacor for the Treatment of Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus
The purpose of the study is to determine whether a 6-week treatment with 4 g Omacor/day improves the baseline and postprandial endothelial function (after a high-fat meal) in patients with type 2 diabetes mellitus.
- Trial name
- NCT00328536
- Testing
- Omacor
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Ruhr University of Bochum
Acute Coronary Syndrome
Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Acute Coronary Syndrome
The purpose of this study is to study the effectiveness of implementation of a systematic LDL-C management pathway including treatment with inclisiran in participants who have experienced a recent acute coronary syndrome (ACS)…
- Trial name
- V-INCEPTION (NCT04873934)
- Testing
- Inclisiran
- Where
- 88 sites in United States
- Volunteers
- 400 people
- Sponsor
- Novartis Pharmaceuticals
Myocardium; Injury, Coronary Artery Disease
Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery.
- Trial name
- AMI-NCS (NCT01960309)
- Testing
- Minimal invasive cardiac imaging
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- UMC Utrecht
Atherosclerosis, Coronary Artery Disease
Early Identification of Subclinical Atherosclerosis Using Non-Invasive Imaging Research (EISNER)
Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research (EISNER) is a multi-study research program being conducted at Cedars-Sinai Medical Center.
- Trial name
- EISNER (NCT00927693)
- Testing
- Coronary Artery Calcium (CAC) Scan
- Where
- United States
- Volunteers
- 2,137 people
- Sponsor
- Cedars-Sinai Medical Center
Coronary Artery Disease
Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease.
- Trial name
- NCT01719016
- Testing
- Cardiac PET, Coronary catheterization
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Cincinnati
Coronary Artery Disease, Ischaemic Heart Desease
Virtual Reality for Patient Preparation Before Cardiac Catheterization in Oman
Background: Cardiovascular disease is considered one of the most prevalent diseases in recent times, and cardiac catheterization is widely used to diagnose and treat cardiovascular disease.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Desease, Cardiac Catheterization
- Trial name
- NCT07320248
- Testing
- Virtual Reality Education
- Volunteers
- 120 people
- Sponsor
- Sultan Qaboos University
Coronary Artery Disease, Cardiac Rehabilitation
Comparison of Conventional and Tele-cardiac Rehabilitation
This study aimed to compare the effects of tele-cardiac rehabilitation (TCR) and hospital-based cardiac rehabilitation (HBCR) on functional capacity (maximum oxygen consumption), fear of activity and quality of life in patients…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Telecardiac Rehabilitation, Aerobic Exercise
- Trial name
- NCT06614634
- Testing
- Remotely supervised exercise at home or outdoors, Hospital-based exercise program, Cardiovascular risk modification
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Coronary Artery Disease
Duration of Platelet Inhibition by Aspirin
The well established importance of regular aspirin administration stands on firm grounds, as large meta-analyses have shown this therapy to significantly reduce the risk of death.
- Trial name
- NCT00671021
- Testing
- Platelet aggregation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Cardiovascular Disease, Coronary Artery Calcification
7 Year Follow-up Study of the DanRisk Population
OBJECTIVES: To investigate the incidence of cardiovascular events as well as progression of coronary artery calcium (CAC) in healthy middle-aged subjects over a period of 7 years, and the relation to traditional as well as new…
- Conditions
- Cardiovascular Disease, Coronary Artery Calcification, Atherosclerosis
- Trial name
- NCT02913144
- Volunteers
- 1,257 people
- Sponsor
- Odense University Hospital
Diastolic Heart Failure
Ranolazine in Diastolic Heart Failure
Patients with CAD and clinical symptoms of heart failure or patients with suspected heart failure with preserved ejection fraction (HFpEF) will be enrolled.
- Trial name
- RALI-DHF (NCT01163734)
- Testing
- Ranolazine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Gilead Sciences
Coronary Artery Disease
Long-Term Follow-up Study of Patients Who Received PB127 Ultrasound Imaging Agent
The purpose of this study is to collect longer term follow-up information concerning health and survival on selected patients who received PB127 for injectable suspension in the pivotal trial (127-014).
- Trial name
- NCT00584714
- Where
- 39 sites in United States
- Volunteers
- 300 people
- Sponsor
- Point Biomedical
Cardiovascular Diseases, Heart Diseases
Reducing Total Cardiovascular Risk in an Urban Community
PLEASE NOTE: THIS STUDY IS ONLY ENROLLING PATIENTS CURRENTLY BEING TREATED AT BELAIR-EDISON FAMILY HEALTH CENTER. The purpose of this study is to compare the clinical effectiveness and cost effectiveness of two cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Diabetes Mellitus
- Trial name
- COACH (NCT00241904)
- Testing
- Lifestyle Changes, Antiplatelet Agents, Beta Blocker
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease, Coronary Disease
Evaluation of Effectiveness and Safety of XIENCE Sierra in Routine Clinical Practice
The objective of this study is to evaluate effectiveness and safety of Xience Sierra stent in the "real world" daily practice as compared with other drug-eluting stents.
- Trial name
- IRIS Sierra (NCT03967158)
- Testing
- Xience Sierra stent
- Where
- 10 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seung-Jung Park
Coronary Artery Diseases
NOYA CoCr Biodegradable Coating Sirolimus-Eluting Coronary Stent System
A single blind, multi-center, randomized study is preformed to compare NOYA CoCr biodegradable coating sirolimus-eluting stents with Firebird2 drug-eluting stents from MicroPort Medical (Shanghai) Co., Ltd.
- Trial name
- NCT01226355
- Testing
- stent
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Medfavour (Beijing) Medical Co., Ltd
Peripheral Artery Disease, Vascular Disease
Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)
Patients scheduled for major extremity lower amputation to receive bone marrow cells (cBMA) injected IM in the leg proximal to the amputation in the index limb to prevent ischemic wound complications after surgery.
- Conditions
- Peripheral Artery Disease, Vascular Disease, Critical Limb Ischemia
- Trial name
- MarrowCHAMP (NCT02863926)
- Testing
- Injection of cBMA aspirate into the index leg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Michael Murphy
Heart Failure Due to Coronary Artery Disease
Optimizing Strategy of Coronary Revascularization in Patients With Multivessel Lesions Combined Heart Failure
As the end stage of almost all cardiovascular diseases, heart failure has become an increasingly common cause of cardiovascular morbidity and mortality worldwide.
- Trial name
- OSCRM-HF (NCT02775578)
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Hybrid Coronary Revascularization
- Where
- China
- Volunteers
- 525 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Ischemic Attack, Transient, Transient Ischemic Attack
Pocket-size Cardiovascular Ultrasound in Stroke
Among patients admitted with cerebral ischemia (stroke and transitory ischemic attack (TIA)) it is important to reveal the underlying cause of the disease.
- Conditions
- Ischemic Attack, Transient, Transient Ischemic Attack, Stroke, Cerebrovascular Accident
- Trial name
- NCT02141932
- Testing
- Bed-side pocket size ultrasound imaging, GE Ultrasound Vscan
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Helse Nord-Trøndelag HF
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