Clinical trials: Arterial Occlusive Diseases
Peripheral Arterial Disease
Chocolate Balloon Angioplasty Registry
To collect data from real-world use with the Chocolate PTA Balloon Catheter to support the effectiveness of the device for use during percutaneous transluminal angioplasty (PTA) procedures.
- Trial name
- Chocolate BAR (NCT01589042)
- Where
- 13 sites in United States
- Volunteers
- 490 people
- Sponsor
- TriReme Medical, LLC
Coronary Artery Disease
Study of the Paclitaxel-Coated Balloon Catheter in Bifurcated Coronary Lesions
This study in bifurcated coronary lesions compares the new technology of the paclitaxel-eluting balloon with the usual technique until now of "provisional stenting" with the paclitaxel-eluting stent in the main branch.
- Trial name
- BABILON (NCT01278186)
- Testing
- Balloon angioplasty, Stent implantation
- Where
- 9 sites in Spain
- Volunteers
- 190 people
- Sponsor
- B.Braun Surgical SA
Coronary Artery Disease and Cardiac Anatomy, Patients Undergoing Coronary CT Angiogram
Relaxation Music to Lower Heart Rate Prior to Cardiac CT
To acquire low radiation dose and good quality cardiac CT images requires scanning at low heart rates which is usually done with beta-blockers. However, in some patients beta-blockers have little effect.
- Conditions
- Coronary Artery Disease and Cardiac Anatomy, Patients Undergoing Coronary CT Angiogram, Patients Undergoing CT Pulmonary Vein Angiogram, Patients Undergoing CT Calcium Score
- Trial name
- NCT02069405
- Testing
- Relaxation Music
- Where
- Canada
- Volunteers
- 197 people
- Sponsor
- University Health Network, Toronto
Peripheral Arterial Disease
Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System® in Below the Knee Arteries
This is a prospective, multi-center, single-arm, non-blinded study designed to investigate the safety and efficacy of the Tack Endovascular System in the Mid/Distal Popliteal, Tibial, and Peroneal Arteries ranging in diameter…
- Trial name
- TOBA II BTK (NCT02942966)
- Testing
- Tack Endovascular System
- Where
- 49 sites in United States, Austria and 4 more
- Volunteers
- 233 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Coronary Artery Disease, Endothelial Function
Effect of Ticagrelor on Endothelial Function
This study is to assess the function of blood vessels while being treated with different types of blood thinners to determine the effect of these medications on blood vessels.
- Trial name
- NCT01805596
- Testing
- clopidogrel, Ticagrelor
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Stable Angina, Vascular Dementia
The Effect of Danzhu Fuyuan Granule as Adjunctive Therapy for Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy: A Bayesian Basket Trial
This study is designed as a bayesian basket trial , which aims to evaluate the efficacy of Danzhu Fuyuan Granule in patients with Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy
- Conditions
- Chronic Stable Angina, Vascular Dementia, Idiopathic Membranous Nephropathy
- Trial name
- NCT04498962
- Testing
- Danzhu Fuyuan Granule
- Where
- 7 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Jingqing Hu
Mild Cognitive Impairment, Alzheimer Disease
Predicting the Conversion From Mild Cognitive Impairment to Dementia
Mild cognitive impairment (MCI) is believed to be the early stage of dementia. The investigators assume that some psychological and imaging risks may predict the conversion.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia, Vascular
- Trial name
- PCMCItoD (NCT01823666)
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Dongzhimen Hospital, Beijing
Atherosclerosis, Aortic Coarctation
Carotid Atherosclerosis in Patients With Aortic Coarctation
Despite aortic coarctation (CoA) repair these patients have cardiovascular complications and coronary artery disease is the most common cause of death.
- Trial name
- CoA (NCT03999073)
- Testing
- Ultrasound measurement
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Atherosclerotic Heart Disease
Endovascular Treatment of Atherosclerotic Lesions in the SFA Using the Sinus-superflex-635 Stent
In this prospective study, a newly developed self-expanding nitinol stent is evaluated for the treatment of atherosclerotic lesions in the superficial femoral artery and proximal popliteal artery.
- Trial name
- NCT01816854
- Testing
- Stenting
- Where
- Belgium
- Volunteers
- 117 people
- Sponsor
- be Medical
NAFLD, Cardiac Disease
Cardiac Dysfunction in Patients with Fatty Liver Disease
Cirrhotic cardiomyopathy is seen as a blunted contractile responsiveness to stress, and/or altered diastolic relaxation with electrophysiological abnormalities, in absence of known cardiac disease.
- Conditions
- NAFLD, Cardiac Disease, Fatty Liver, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
- Trial name
- NCT06386094
- Testing
- Echocardiographic assessment
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Peripheral Arterial Disease
Post-Market Clinical Follow Up of Rotarex®S Catheter
Post-Market Clinical Follow Up of the Rotarex®S Catheter
- Trial name
- NCT04010123
- Testing
- Atherectomy/Thrombectomy
- Where
- 13 sites in Czechia, Estonia and 3 more
- Volunteers
- 220 people
- Sponsor
- Straub Medical AG
Critical Limb Ischemia, Peripheral Arterial Disease
Chelation Therapy in Diabetic Patients With Critical Limb Ischemia
This is a Pilot Trial Using Chelation Therapy for Limb Preservation in Diabetic Patients with Critical Limb Ischemia.
- Trial name
- TACT-PAD (NCT03424746)
- Testing
- disodium EDTA
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Cardiovascular Diseases, Coronary Artery Disease
Research of Resistance to Antiplatelet Agents and Development of Tailored Treatment Model for Patients With Coronary Artery Disease
The purpose of this study is to evaluate the prognosis of patients with resistance to antiplatelet agent and develop tailored treatment model for patients with coronary artery disease.
- Trial name
- NCT02121054
- Where
- South Korea
- Volunteers
- 1,527 people
- Sponsor
- Young-Hak Kim, MD, PhD
Critical Limb Ischemia
A Long Term Follow-up Study of AMG0001 in Subjects With Critical Limb Ischemia
Subjects from the AG-CLI-0206 phase 3 study that received AMG0001 will be eligible for the AG-CLI-0206-LTFU study
- Trial name
- NCT02974179
- Testing
- Subjects from Study AG-CLI-0206 who received AMG0001
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- AnGes USA, Inc.
Coronary Artery Disease, Type 2 Diabetes Mellitus
Arginase Inhibition in Ischemia-reperfusion Injury
The present project is designed to test the hypothesis that arginase contributes to endothelial dysfunction induced by ischemia-reperfusion in patients with coronary artery disease.
- Trial name
- NCT02009527
- Testing
- N-hydroxy-nor-arginine, NaCl
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Chronic Total Occlusion (CTO)
TRIO CTO (Taiwan Research Initiative on Coronary Total Occlusion)
Coronary chronic total occlusions (CTO) present a significant challenge in the field of interventional cardiology. These complex lesions, characterized by complete blockage of a coronary artery for a prolonged duration, often…
- Trial name
- NCT06917378
- Testing
- Percutaneous coronary intervention of coronary chronic total occlusion
- Where
- 3 sites in Taiwan
- Volunteers
- 5,000 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Training at Different Intensities in Coronary Artery Disease -Effects on Myocardial Function
The study investigated if aerobic endurance exercise of different intensity has different impact on the physical capacity and myocardial function in patients with coronary artery disease.
- Trial name
- NCT00201591
- Testing
- Exercise training for 10 weeks
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease, Valve Disease, Heart
Assessment of Strength Outcomes After Use of the PrimusRS for Specificity of Training in a Cardiac Rehabilitation Setting
The purpose of this study is to determine if performed force measurements yield a different recommended weight lifted during the sternotomy healing process than the traditional gold standard of 5 pounds.
- Trial name
- NCT05924568
- Testing
- Educational session with Keep Your Move in the Tube and PrimusRS
- Sponsor
- Brandon Hathorn
Coronary Artery Disease
Two-stent vs Provisional Stenting Techniques for Patients With Complex Coronary Bifurcation Lesions
The purpose of this study is to establish the optimal strategy for stenting in coronary bifurcation lesion.
- Trial name
- DEFINITION-II (NCT02284750)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease, Microcirculation
Aged Garlic Extract Study
The primary intention of the study is to examine the effect of aged garlic extract (AGE) on the absolute change in coronary artery calcium (CAC).
- Conditions
- Coronary Artery Disease, Microcirculation, Biomarkers
- Trial name
- AGE (NCT03860350)
- Testing
- Aged Garlic Extract
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
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