Clinical trials: Arterial Occlusive Diseases
Atherosclerosis, Coronary Artery Disease
The Effect of Atorvastatin and Pioglitazone on Carotid Atherosclerosis With the Use of Positron Emission Tomography-computed Tomography (PET-CT)
This study is a prospective randomized clinical trial and to compare the antiinflammatory effect of atorvastatin single therapy and atorvastatin and pioglitazone combination therapy in carotid arteries of stable and unstable…
- Trial name
- PIONEER (NCT01341730)
- Testing
- Atorvastatin 20mg, Atorvastatin 20 mg + Pioglitazone 30 mg
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- The Catholic University of Korea
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Stroke, Ischemic, Infarction, Middle Cerebral Artery
Testing of Identification Markers for Stroke
Stroke is the third leading cause of death and the first cause of physical disability and dementia worldwide. Ischemic stroke caused by large vessel occlusion (LVO) is responsible for the vast majority of deaths and disabilities.
- Conditions
- Stroke, Ischemic, Infarction, Middle Cerebral Artery, Infarction, Anterior Circulation, Brain
- Trial name
- TIME (NCT04292600)
- Testing
- POCKiT diagnostics' algorithm for LVO detection
- Where
- 3 sites in United States
- Volunteers
- 383 people
- Sponsor
- POCKiT diagnostics Ltd
Diabetes Mellitus, Hypertension
Rajavithi Health Promotion Project (Population Base Cohort)
Metabolic Syndrome (hypertension, diabetes mellitus, obesity, cerebrovascular-cardiovascular disease) In Community Survey was performed in central Bangkok.
- Conditions
- Diabetes Mellitus, Hypertension, Dyslipidemia, Obesity
- Trial name
- NCT00368095
- Testing
- Intensive Education for Metabolic Syndrome Patients
- Where
- Thailand
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Aortoiliac Atherosclerosis, Aortoiliac Occlusive Disease
IUA Committee Research Project on the Management of TASC C and D Aortoiliac Lesions
This study aims to evaluate the clinical, imaging results of endovascular revascularization of the aorto-iliac sector in comparison with aortobifemoral bypass and the hybrid approach, in patients with atherosclerotic disease of…
- Conditions
- Aortoiliac Atherosclerosis, Aortoiliac Occlusive Disease, Aortoiliac Atherosclerosis With Gangrene, Aortoiliac Atherosclerosis Without Gangrene
- Trial name
- NCT06260475
- Testing
- Aortobifemoral bypass, aortoiliac stenting
- Where
- 2 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Universidade do Porto
Coronary Artery Disease
Monitoring and Characterization of Coronary Flow By Transthoracic Parametric Doppler (TPD) During Exercise Stress Test
The study is an open prospective study of coronary flow preferably of the left anterior descending artery (LAD), by a Transthoracic Parametric Doppler (TPD) system during conventional exercise stress test.
- Trial name
- NCT01089777
- Testing
- ultrasound Doppler monitoring
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Echosense Ltd.
Cardiovascular Diseases, Coronary Disease
Genetics of Atherosclerosis in Mexican Americans
To identify individual genes that contribute to variation in susceptibility to coronary heart disease (CHD) in Mexican Americans.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Obesity, Atherosclerosis
- Trial name
- NCT00005462
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, HMG-CoA Reductase Inhibitor Toxicity
Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients
The present study constitutes a study examining the effect of atorvastatin on vascular function in high cardiovascular risk patients.
- Conditions
- Coronary Artery Disease, HMG-CoA Reductase Inhibitor Toxicity, Atherosclerosis, Oxidative Stress
- Trial name
- NCT01013103
- Testing
- Atorvastatin, high vs low dose
- Where
- Greece
- Volunteers
- 72 people
- Sponsor
- Hippocration General Hospital
Coronary Arteriosclerosis, Heart Failure, Congestive
Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study)
Viability assessment remains a clinical challenge in patient with coronary artery disease and left ventricular dysfunction. Several imaging modalities are available for evaluating myocardial viability, based either on perfusion…
- Conditions
- Coronary Arteriosclerosis, Heart Failure, Congestive, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT00213746
- Where
- 8 sites in Belgium, France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Rouen
Atherosclerosis
68Ga-FAPI PET/MR for Atherosclerosis
A thin-cap fibroatheroma with a large necrotic core and macrophage infiltration marks the vulnerable plaque. Fibroblast activating protein (FAP) is an active serine protease, which can degrade type I collagen, potentially…
- Trial name
- NCT05036759
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Myocardial Ischemia, Coronary Artery Disease
A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients
This is a multi-centre, open-label, single-dose safety, tolerability and PK-pharmacodynamics (PD) study of the vasodilator regadenoson in 3 paediatric age groups for whom a pharmacologic stress perfusion CMR test is clinically…
- Trial name
- Rapiscan PIP (NCT04604782)
- Testing
- Regadenoson
- Where
- 5 sites in France, Greece and 2 more
- Volunteers
- 54 people
- Sponsor
- GE Healthcare
Cardiovascular Diseases, Heart Diseases
Inflammation: Correlates and Prognosis in Framingham
To determine the relation between cardiovascular disease risk factors and systemic markers of vascular inflammation in the Framingham Study cohort.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- NCT00006403
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Stenosis, Cerebral Hyperperfusion Syndrome
Accuracy of TCD Monitoring in Predicting Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy
Background: Cerebral hyperperfusion syndrome (CHS) is a life threatening complication of carotid endarterectomy (CEA) and the changes of middle cerebral artery velocity are used to predict the occurrence of CHS but the accuracy…
- Conditions
- Carotid Stenosis, Cerebral Hyperperfusion Syndrome, Blood Pressure
- Trial name
- NCT01799070
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease
Prasugrel With Lower Dose - Loading Dose
Although prasugrel, recently available thienopyridine derivative, exhibits rapid and potent platelet inhibition, concerns of low on-treatment platelet reactivity have been suggested especially in East Asian ethnicities.
- Trial name
- PRELOAD-LD (NCT02070159)
- Testing
- Clopidogrel 600 mg, Prasugrel 30 mg, Prasugrel 60 mg
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Dong-A University
Alzheimer Disease, Vascular Dementia
Working Memory Functioning in Alzheimer's Disease and Vascular Dementia
The aim of the present study is to investigate potential cognitive mechanisms contributing to working memory impairment in Alzheimer's disease and vascular dementia.
- Conditions
- Alzheimer Disease, Vascular Dementia, Mixed Dementias
- Trial name
- MEMTRAV-COG (NCT06321380)
- Testing
- Complex span task, Clinical neuropsychological assessment, Clinical neurospychological assessement
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Coronary Artery Disease
9 Months Extension Study of SOMVC001 Study (GALA) Vascular Conduit Preservation Solution
This is a 9-months extension to the following study, protocol number: 003-03: "A study to evaluate the use of SOMVC001 (GALA) vascular conduit preservation solution in patients undergoing coronary artery bypass grafting (GABG)".
- Trial name
- NCT02774824
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Perrault Louis P.
Atherosclerosis, Endothelial Dysfunction
Predictive Medicine Research
To establish normal values by age, race, and gender of novel markers of risk in healthy subjects necessary to predict precise risk of cardiovascular disease in an individual
- Trial name
- NCT00384761
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Emory University
Coronary Artery Disease, Cardiomyopathy
Efficacy of Dotarem® (Gd-DOTA) Versus Gadovist® (Gd-DO3A-butrol) for Late Gadolinium Enhancement Cardiac Magnetic Resonance
This project is designed to demonstrate equivalence of Dotarem enhanced LGE-CMR (late gadolinium enhancement cardiac MRI) with Gadoviost enhanced LGE-CMR from the standpoint of visual image quality, quantitative image quality…
- Trial name
- NCT03057561
- Testing
- Cardiac MRI taken using contrast agent, Dotarem® (Gd-DOTA), Cardiac MRI with contrast agent, Gadovist
- Volunteers
- 120 people
- Sponsor
- The Methodist Hospital Research Institute
Coronary Artery Disease, Coronary Artery Disease Progression
Clinical Features, Current Treatment and Clinical Outcomes in Patients With INR-CAD: a Cohort Study
This is a cohort study to investigate the clinical features, current treatment and clinical outcomes in patients with inflammation-associated non-rapidly-progressive coronary artery disease (INR-CAD).
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Artery Stenosis, Coronary Artery Restenosis
- Trial name
- NCT06845410
- Testing
- Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease
Development and Translation of Generator-Produced PET Tracer for Myocardial Perfusion Imaging-Dosimetry Group
This study is a single center, early phase 1 clinical imaging study designed to assess the dosimetry of 68Ga-Galmydar for PET/CT imaging.
- Trial name
- GALMYDAR (NCT05280782)
- Testing
- Ga-68 Galmydar
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
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