Clinical trials: Arterial Pressure
Hypogonadism, Male
Ambulatory Blood Pressure Monitoring (ABPM) Extension Study of Oral Testosterone Undecanoate in Hypogonadal Men
The purpose of this six-month treatment study is to assess feasibility of a lower starting dose of SOV2012-F1 (daily dose of 400 mg [200 mg with breakfast meal and 200mg with dinner meal]) to titrate individual doses to further…
- Trial name
- NCT04467697
- Testing
- SOV2012-F1
- Where
- 19 sites in United States
- Volunteers
- 155 people
- Sponsor
- Marius Pharmaceuticals
Hypertension
A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension
The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.
- Trial name
- KARDIA-1 (NCT04936035)
- Testing
- ALN-AGT01
- Where
- 75 sites in United States, Canada and 3 more
- Volunteers
- 394 people
- Sponsor
- Alnylam Pharmaceuticals
High Cholesterol, High Blood Pressure
Online Trial Examining Validity and Reliability of the Shared Decision Making Process Survey
The purpose of this study is to survey a sample of adults who have recently made a decision about treatment of high cholesterol or high blood pressure or a decision about screening for colorectal cancer, breast cancer, or…
- Conditions
- High Cholesterol, High Blood Pressure, Colorectal Cancer, Breast Cancer
- Trial name
- NCT04317690
- Where
- United States
- Volunteers
- 539 people
- Sponsor
- Massachusetts General Hospital
Hypertension
Uncontrolled Hypertension Among the Homeless
This study is designed to assess the effect of implementing a mobile health (mHealth) strategy using text messaging for hypertension (HTN) management among hypertensive homeless persons with uncontrolled blood pressure age 21 or…
- Trial name
- NCT05187013
- Testing
- mHealth for Hypertension in Homeless Persons
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- George Washington University
Blood Pressure
Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) Trial
The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended…
- Trial name
- NOAAH (NCT01030458)
- Testing
- amlodipine 5/10 mg per day plus valsartan 160 mg/day, hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day
- Where
- 7 sites in Cameroon, Côte d’Ivoire and 3 more
- Volunteers
- 183 people
- Sponsor
- KU Leuven
Healthy
A Study of Lasmiditan and Propranolol in Healthy Participants
This study will assess the effects on heart rate and blood pressure when a single dose of lasmiditan is administered with a daily dose of propranolol.
- Trial name
- NCT03270644
- Testing
- Lasmiditan, Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Osteopenia, Arterial Hypertension
Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women
This study evaluates the effect of moxonidine versus bisoprolol on collagen type 1 C-telopeptide in postmenopausal female patients with arterial hypertension and osteopenia.
- Trial name
- COMPASS (NCT02355821)
- Testing
- Moxonidine, Bisoprolol
- Where
- Russia
- Volunteers
- 114 people
- Sponsor
- National Research Center for Preventive Medicine
Hypertension
Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide
Patients who have obstructive sleep apnea (OSA) frequently stop breathing while they sleep. They often develop high blood pressure. We are not sure what drug is best to treat the high blood pressure.
- Trial name
- nebhctz (NCT02710071)
- Testing
- Nebivolol, Hydrochlorothiazide
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Heart Diseases, Cardiovascular Diseases
Trial Evaluating New Strategy in the Functional Assessment of 3-vessel Disease Using SYNTAXII Score in Patients With PCI
Clinical study that aims to evaluate a new strategy using the SYNTAX II Score calculator in the functional assessment of patients with new coronary 3-vessel-disease who undergo percutaneous coronary intervention (PCI)
- Conditions
- Heart Diseases, Cardiovascular Diseases, 3 Vessel Coronary Artery Disease
- Trial name
- NCT02015832
- Testing
- Coronary stent, Multi Slice Computed Tomography, instantaneous wave-free ratio
- Where
- 22 sites in Netherlands, Poland and 2 more
- Volunteers
- 454 people
- Sponsor
- ECRI bv
Essential Hypertension
A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential Hypertension
The purpose of this study is to assess the long-term safety, tolerability and efficacy of LCZ696.
- Trial name
- NCT01256411
- Testing
- LCZ696, Amlodipine, Hydrochlorothiazide (HCTZ)
- Where
- 33 sites in China, Japan and 3 more
- Volunteers
- 341 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, Pregnancy-Induced
Hypertension In Postpartum Preeclampsia Study
This study aims to evaluate whether NSAIDs (Non-steroidal antiinflammatory drugs) administered during the postpartum period influence blood pressure in women with hypertensive disorders of pregnancy.
- Trial name
- HIPPS (NCT03011567)
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- MemorialCare Health System
Hypertension
Extension Study to Assess Long Term Safety, Tolerability, and Efficacy of Valsartan and Enalapril Combined and Alone in Children With Hypertension
The purpose of this extension study is to compare the long-term safety of valsartan versus enalapril, and the effectiveness of the combination of valsartan and enalapril versus enalapril alone in children with hypertension.
- Trial name
- NCT00446511
- Testing
- Valsartan, Enalapril
- Where
- 9 sites in United States, Belgium and 7 more
- Volunteers
- 250 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Effect of High and Low Sodium Diets on Blood Pressure in Hypertensive Patients Treated With Aliskiren
This study will compare the effects of high and low level sodium (salt) diets on blood pressure in patients with hypertension (high blood pressure) who are taking aliskiren 300 mg.
- Trial name
- NCT00441064
- Testing
- Aliskiren
- Where
- 19 sites in United States
- Volunteers
- 132 people
- Sponsor
- Novartis
Cardiovascular Diseases, Hypertension
Clinical Trial of Dietary Protein and Blood Pressure
The purpose of this study is to examine the effect of dietary protein supplements on high blood pressure (BP).
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Diseases
- Trial name
- ProBP (NCT00046566)
- Testing
- Soy protein-milk protein-carbohydrate, Milk protein-carbohydrate-soy protein, Carbohydrate-soy protein-milk protein
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Tulane University
Moderate to High-risk Noncardiac Surgery
Hypotension Prediction Index (HPI) SMART-BP Trial
A multicenter, randomized comparison of intraoperative hemodynamic management with or without a protocolized strategy utilizing Hypotension Prediction Index (HPI) software guidance during moderate-to-high-risk noncardiac surgery.
- Trial name
- NCT05105477
- Testing
- AcumenTM HPI Software Feature, Non-protocolized Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 407 people
- Sponsor
- Edwards Lifesciences
Spinal Cord Injury
Transcutaneous Stimulation in Spinal Cord Injury
Cardiovascular disease has become the leading cause of death in the spinal cord injury population. Increased reliance on the renin-angiotensin-aldosterone system (RAAS) is believed to decrease falls in blood pressure when moving…
- Trial name
- SCI (NCT05180227)
- Testing
- DS8R
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Hypertension
Assessment of Efficacy and Safety of Olmesartan Medoxomil in Children and Adolescent Patients With High Blood Pressure
This study assesses the efficacy and safety of olmesartan medoxomil in children ages 1-16 with high blood pressure. After a 5-week blinded treatment period of up to 5 weeks participants can continue to take olmesartan medoxomil…
- Trial name
- NCT00151775
- Testing
- olmesartan medoxomil
- Where
- 65 sites in United States, Argentina and 9 more
- Volunteers
- 362 people
- Sponsor
- Daiichi Sankyo
Heart Failure, Heart Failure, Systolic
Hemodynamic-GUIDEd Management of Heart Failure
The GUIDE-HF IDE clinical trial is intended to demonstrate the effectiveness of the CardioMEMS™ HF System in an expanded patient population including heart failure (HF) patients outside of the present indication, but at risk for…
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure NYHA Class II
- Trial name
- GUIDE-HF (NCT03387813)
- Testing
- CardioMEMS™ HF System
- Where
- 129 sites in United States, Canada
- Volunteers
- 2,358 people
- Sponsor
- Abbott Medical Devices
Vascular Function
Flow Mediated Dilation in Response to Black Tea
Research indicate that people who regularly drink tea have a reduced risk of stroke or heart disease. In a number of studies in which people that normally do not drink showed that their blood vessels function improved when the…
- Trial name
- T (NCT02273323)
- Testing
- Tea
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Unilever R&D
Hypertension, Cardiovascular Disease
Safety and Efficacy Study of Angiotensin Therapeutic Vaccine in Subjects With Mild to Moderate Hypertension
Angiotensin Therapeutic Vaccine (ATV), which contains the novel adjuvant, CoVaccine HT™ , is being developed for the treatment of high blood pressure (hypertension), a major risk factor for serious diseases such as heart attacks…
- Trial name
- NCT00702221
- Testing
- Angiotensin Therapeutic Vaccine plus CoVaccine HT™ adjuvant, CoVaccine HT™ adjuvant
- Where
- 12 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- BTG International Inc.