Clinical trials: Arterial Ulcers
Peripheral Vascular Disease, Diabetic Foot
Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia
Critical limb ischemia is a condition where the blood circulation in the limbs, in most cases the legs, is decreased so that pain and non healing wounds ensue. Mostly, this is a sequel of arteriosclerosis and/or diabetes.
- Conditions
- Peripheral Vascular Disease, Diabetic Foot, Peripheral Arterial Occlusive Disease, Leg Ulcer
- Trial name
- BONMOT (NCT00434616)
- Testing
- Autologous bone marrow cell concentrate transplantation, saline injection
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Franziskus-Krankenhaus
Peptic Ulcer Hemorrhage
Supplementary Angiographic Embolization for Peptic Ulcer Bleeding
Peptic ulcer bleeding is a common disorder. Despite optimal endoscopic and medical treatment, there is a high risk of rebleeding and high mortality.
- Trial name
- NCT01125852
- Testing
- Angiographic embolization, Therapeutic endoscopy
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- Odense University Hospital
Diabetic Ulcers, Arterial Ulcers
Multicenter, Randomized, Non-inferiority Study to Compare the Performance and Safety of Debrisoft® Duo With Debrisoft® Pad in the Debridement of Wounds
The aim of this post market clinical follow up (PMCF) study is to confirm the performance of Debrisoft® Duo, to collect safety data regarding expected adverse events and to detect potential unexpected adverse events associated…
- Conditions
- Diabetic Ulcers, Arterial Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- NCT07312513
- Testing
- two sided debridement pad, one sided debridment pad
- Where
- 5 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Lohmann & Rauscher
Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM)
The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM
This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 5.
- Conditions
- Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM), Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT03174522
- Testing
- REX-001
- Where
- 15 sites in Czechia, Hungary and 4 more
- Volunteers
- 49 people
- Sponsor
- Ixaka Ltd
Thoracic Aortic Aneurysm, Penetrating Aortic Ulcer
Zenith Thoracic Alpha (ZTA) Post-Market Data Collection
This study aims to gather real-world clinical data demonstrating the continued safety and performance of the a marketed stent graft (Zenith® Alpha Thoracic Endovascular Graft [ZTA]) and collect longer term follow-up to better…
- Trial name
- NCT06094127
- Testing
- Endovascular aortic treatment
- Where
- 10 sites in France, Germany and 2 more
- Volunteers
- 300 people
- Sponsor
- Cook Research Incorporated
Diabetic Foot, Ischemic Diabetic Foot Ulcer
Appropriate Strategy of Surgical Treatment in Ischemic Diabetic Foot
This cohort study aims to evaluate the outcomes of appropriate surgical treatment strategies in diabetic foot ulcers with different rate of popliteal artery stenosis(<50% or ≥50%).
- Conditions
- Diabetic Foot, Ischemic Diabetic Foot Ulcer, Popliteal Artery Stenosis
- Trial name
- NCT04709887
- Testing
- Wound treatment, Vascular intervention surgery, Tibial transverse transport surgery
- Where
- China
- Volunteers
- 332 people
- Sponsor
- Peking University People's Hospital
Leg Ulcer
Speckle Study: In Arterial, Mixed and Diabetic Foot Ulcers
This is a single centre open label study measuring microcirculatory flux using Speckle imaging Device. Microcirculation will be measured using laser speckle contrast imaging, at baseline and with the device active for 30 minutes…
- Trial name
- NCT03186560
- Testing
- gekoTM
- Where
- 3 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- Firstkind Ltd
Critical Limb Ischemia, Atherosclerosis
Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells
The purpose of this study is to determine the safety and efficacy of G-CSF-mobilized autologous peripheral blood mononuclear cell injection to ischemic limbs of patients with critical limb ischemia.
- Conditions
- Critical Limb Ischemia, Atherosclerosis, Ischemic Ulcer, Gangrene
- Trial name
- NCT01833585
- Testing
- Peripheral blood mononuclear cell
- Where
- Thailand
- Volunteers
- 8 people
- Sponsor
- Mahidol University
Foot Ulcers, Arteriosclerosis Obliterans
HELP-Apheresis in Diabetic Ischemic Foot Treatment (H.A.D.I.F)
Diabetic foot (DF) is a common, severe and costly complication of diabetes. DF is underlied by neuropathy, atherosclerosis of distal arteries and infection, which result in tissue ulcers and necrosis.
- Conditions
- Foot Ulcers, Arteriosclerosis Obliterans, Diabetes Mellitus
- Trial name
- HADIF (NCT01518205)
- Testing
- LDL-apheresis
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Universita di Verona
Leg Pain, Ulcer
Stem Cell Study for Patients With Leg Ulcer/Gangrene
The purpose of this study is to determine if stem cell therapy with one's own cells (autologous cells) delivered intramuscularly to one's leg with ulcer and/or gangrene due to poor blood flow will be safe and if it will relieve…
- Conditions
- Leg Pain, Ulcer, Gangrene, Ischemia
- Trial name
- NCT00221143
- Testing
- Autologous peripheral blood CD34 positive cell therapy
- Where
- 2 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
PVD, Arterial Ulcers
Effect of HPIPC for the Treatment of Ischemic Ulcers in Subjects With PAD
To evaluate the effects of HPIPC for the treatment of symptoms of PAD
- Trial name
- NCT01420289
- Testing
- High pressure intermittent pneumatic compression (HPIPC), Excercise
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Calvary Hospital, Bronx, NY
Hard-to-heal Wounds, Diabetic Foot Ulcer
Clinical Investigation of Sorbact® Dressings
The main purpose of this exploratory clinical investigation is to study the binding of bacteria and fungi from hard-to-heal wounds to the DACC-coated dressings.
- Conditions
- Hard-to-heal Wounds, Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
- Trial name
- NCT05089890
- Testing
- Sorbact® Compress, Sorbact® Gel Dressing, Sorbact® Ribbon Gauze
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- ABIGO Medical AB
Thoracic Aortic Aneurysm
The CardiOvascular Remodeling Following Endovascular Aortic Repair (CORE) Study
The use of TEVAR is increasing rapidly and patients even in younger patients. However, current endografts are several orders of magnitude stiffer than the native aorta.
- Trial name
- CORE (NCT02735720)
- Testing
- TEVAR, Non-TEVAR medical treatment
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Systemic Sclerosis, Pulmonary Arterial Hypertension
Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis
Systemic sclerosis is a multisystem autoimmune disease characterized by vascular dysfunction, immune dysregulation, and progressive tissue fibrosis.
- Conditions
- Systemic Sclerosis, Pulmonary Arterial Hypertension, Digital Ulcers, Vascular Complications
- Trial name
- EVOLVE-SSc (NCT07717060)
- Testing
- Blood sampling, nailfold capillaroscopy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Aortic Aneurysm, Aortic Dissection
A Novel Wire-Reinforced Fenestration of a Hybrid Frozen Elephant Trunk Device for Supra-Aortic Branch Vessel Stenting During Aortic Arch Replacement
The goal of this prospective, non-randomized trial is to determine the safety and technical success of a novel modification to a U.S.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Penetrating Aortic Ulcer (PAU), Aortic Pseudoaneurysm
- Trial name
- SA-FET (NCT07885865)
- Testing
- Modified Supra-Aortic Frozen Elephant Trunk (SA-FET) Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Thoracic Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs)
MBA Early Feasibility Study
The MBA 25-04 study is a prospective, multicenter, non-randomized, single-arm, early feasibility study designed to assess the initial safety of the MBA device through five years following the index endovascular procedure.
- Conditions
- Thoracic Aortic Aneurysm, Penetrating Aortic Ulcers (PAUs), Thoracic Aortic Dissection, Pseudoaneurysm
- Trial name
- NCT07564375
- Testing
- GORE® Multibranch Arch Endoprosthesis, GORE® Ascending Stent Graft
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- W.L.Gore & Associates
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry
Diabetic Foot
Autologous Endothelial Progenitor Cells Treatment of Diabetic Foot
The vascular pathologic basis of diabetic foot include arterial obstruction and micro-circulation defects.The latest technology of arterial reconstruction can only rebuild blood flow of anterior,posterior tibial artery and…
- Trial name
- NCT02474381
- Testing
- EPCs plus PTA, Single PTA
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Juxtarenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm
Modified Preloaded System for Renal Arteries in Fenestrated Endografting (MPSRA)
Advanced Endovascular repair of aneurysms and dissections involving thoraco-abdominal (type I-IV) and complex abdominal (juxta and para-renal) aorta is a ground-gaining procedure allowing favorable results in high surgical risk…
- Conditions
- Juxtarenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Pararenal Aortic Aneurysm, Aortic Aneurysm, Thoracoabdominal
- Trial name
- MPSRA (NCT05224219)
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Bologna
Diabetes, Diabetic Foot Ulcer
Electrical Stimulation to Accelerate Wound Healing
A clinical study at the Baylor College of Medicine, Division of Vascular Surgery and Endovascular Therapy, is being proposed to test the efficacy of a novel electrical stimulation platform named the Tennant Biomodulator designed…
- Conditions
- Diabetes, Diabetic Foot Ulcer, Peripheral Neuropathy, Peripheral Arterial Disease
- Trial name
- NCT03821675
- Testing
- Electrical Stimulation - Active
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Baylor College of Medicine