Clinical trials: Arteriosclerosis
Coronary Artery Disease, Coronary Artery Stenosis Stent
Deep Learning CAD Screening on Chest CT
Coronary artery disease (CAD) is one of the leading causes of death worldwide. Many people have early atherosclerosis without symptoms, and some may develop significant coronary stenosis before any warning signs appear.
- Trial name
- CAD-AI (NCT07181512)
- Testing
- Deep Learning Analysis of Non-contrast Chest CT
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yifan Guo
Coronary Artery Disease, Calcification
Rotablation vs Intravascular Lithotripsy in Calcified Coronary Lesions
Prospective, 1:1 randomized, controlled, multicenter trial to assess effectiveness and safety of Intravascular Lithotripsy (IVL) compared to Rotational Atherectomy (RA) treatment in calcified coronary lesions
- Trial name
- DECALCIFY (NCT04960319)
- Testing
- Intravascular Lithotripsy
- Volunteers
- 100 people
- Sponsor
- Medical Care Center Prof. Mathey, Prof. Schofer, Ltd.
Peripheral Arterial Disease, Atherosclerosis
Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease
The nitinol stent has proven superior primary patency than balloon angioplasty in superficial femoral artery lesions. Recent stent design improvements focus on decreasing stent fracture rates which can negatively impact patency…
- Trial name
- SENS-FP-2 (NCT01653600)
- Testing
- S.M.A.R.T CONTROL Stent, LifeStent
- Where
- South Korea
- Volunteers
- 346 people
- Sponsor
- Korea University Guro Hospital
CAD - Coronary Artery Disease, Inflamation
Effect of Empagliflozin on Inflammation
Empagliflozin is a drug given to lower glucose. It is used in the treatment of diabetes. However, it was shown to improve symptoms and survival of patients who are suffering from heart failure.
- Conditions
- CAD - Coronary Artery Disease, Inflamation, PCI, SGLT 2 Inhibitors
- Trial name
- EMPANTINFLAM (NCT07292909)
- Testing
- Empagliflozin (SGLT2i)
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Hotel Dieu de France Hospital
Coronary Artery Disease
Cardiovascular Effects of a Soccer Match in Viewers With With Coronary Artery Disease
Watching football matches could cause increased blood pressure and heart rate induced by catecholamines and thus increase the incidence of cardiovascular events.
- Trial name
- NCT01754675
- Testing
- Soccer, Movie
- Where
- Brazil
- Volunteers
- 17 people
- Sponsor
- Instituto de Cardiologia de Santa Catarina
Atherosclerosis, Cardiovascular Diseases
Atherosclerosis in Rheumatoid Arthritis
To test the theory that accelerated inflammation-promoted atherosclerosis occurs in patients with rheumatoid arthritis (RA).
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Inflammation
- Trial name
- NCT00037336
- Sponsor
- Vanderbilt University
Postmenopausal Women, Stable Angina Pectoris
Coronary Artery Disease (CAD) in Postmenopausal Women
Aim of this study is the determination of a valid procedure for ischemia diagnositc in postmenopausal women.
- Trial name
- FEMCAD (NCT00763464)
- Testing
- stress-echocardiography, stress-MRI
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Diabetes, Endothelial Dysfunction
Magnetic Resonance Imaging of Vascular Function
A major function of blood vessels is to control blood flow by dilating or constricting depending on the demand. Vascular dysfunction is a state in which blood vessels fail to carry out its normal roles such as regulating blood…
- Trial name
- NCT02206919
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Coronary Artery Disease, Erectile Dysfunction
Pudendal Atherosclerosis by IVUS-NIRS in Men With Coronary Artery Disease
This prospective, single-center, exploratory study will evaluate the association between atherosclerotic and lipid plaque burden in the internal pudendal arteries, assessed by intravascular ultrasound and near-infrared…
- Conditions
- Coronary Artery Disease, Erectile Dysfunction, Atherosclerosis
- Trial name
- PUDENDAL-NIRS (NCT07856199)
- Testing
- Selective Pudendal Angiography, Pudendal IVUS-NIRS Imaging
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Central Militar
Cardiovascular Diseases, Coronary Artery Disease
Optimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation
The primary aim of this research is to explore the adherence and drop-out from early cardiac rehabilitation (CR), to inform interventions to support patient's adherence to CR and facilitate maintenance.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- OSPREY-CR (NCT04781699)
- Where
- 6 sites in United Kingdom
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Peripheral Artery Disease, Atherosclerosis
Efficacy of Balloon-Expandable Stent Versus Self-Expandable Stent for the Atherosclerotic ILIAC Arterial Disease
The purpose of the investigators study is to examine and compare primary patency between balloon expandable cobalt chromium stent and self expandable nitinol stents (SCUBA versus COMPLETE-SE) in atherosclerotic iliac artery…
- Trial name
- NCT01834495
- Testing
- Balloon expandable stent, Self expandable stent
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Korea University Guro Hospital
Intracranial Arteriosclerosis, Cognitive Impairment
Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial
This study aims to evaluate whether digital cognitive training and/or PCSK9 inhibitor-enhanced lipid-lowering therapy on top of moderate-intensity statin can improve cognitive function in patients with intracranial…
- Trial name
- NCT07605130
- Testing
- Rosuvastatin, Ezetimibe, Recaticimab
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Atherosclerosis
AFRICA: Atorvastatin Plus Fenofibric Acid (TriLipix) in the Reduction of Intermediate Coronary Atherosclerosis
This study will examine how an approved drug (TriLipix), when used in combination with a statin (a drug that lowers blood cholesterol levels), affects the makeup of plaque.
- Trial name
- AFRICA (NCT01030328)
- Testing
- TriLipix
- Where
- United States
- Sponsor
- Piedmont Healthcare
Cardiovascular Diseases, Heart Diseases
Genetics of CVD Risk Factors in Samoans
To evaluate the role of known genes involved in lipid metabolism on serum lipid and apolipoprotein levels in Samoans residing in American and Western Samoa, who were exposed to the biobehavioral changes of modernization.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Atherosclerosis
- Trial name
- NCT00005528
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Latin America Real World Study With Inspiron Drug Eluting Stent - INSPIRON LATITUDE
Prospective, multicenter, single arm registry to monitor post-market clinical outcomes of patients treated with Inspiron Sirolimus-Eluting Stent with Biodegradable Polymer.
- Trial name
- LATITUDE (NCT03471234)
- Testing
- Angioplasty
- Where
- 2 sites in Brazil
- Volunteers
- 299 people
- Sponsor
- Scitech Produtos Medicos SA
Myocardial Ischemia
A Study on Improved Dynamic Myocardial Perfusion With Less Effective Radiation Dose in CT (SIMPLE CT)
Among the current myocardial CT perfusion techniques, dynamic CT perfusion technique is most advantageous in obtaining information on myocardial blood flow and volume.
- Trial name
- NCT02161081
- Testing
- Myocardial CT perfusion
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Myocardial and Arterial Phenotype of Coronary Artery Disease
The CAD-MAP (Myocardial and Arterial Phenotype of Coronary Artery Disease) registry is initiated with the goal to describe the cardiac imaging map including epicardial coronary artery, coronary microcirculation and myocardium…
- Trial name
- CAD-MAP (NCT06202300)
- Testing
- Inflammation burden
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Anzhen Hospital
Peripheral Artery Disease
Ankle-foot Orthoses for Peripheral Artery Disease
The primary aim of this study is to investigate the effect of an ankle foot orthoses (AFO) on the primary outcome of peak walking time (PWT) in patients with peripheral artery disease (PAD).
- Trial name
- NCT02280200
- Testing
- AFO to improve outcomes
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Minnesota
Peripheral Artery Disease
NAD Supplementation and Vascular Health in PAD
This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation, cerebrovascular hemodynamics, cognitive function in older…
- Trial name
- NCT06534944
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Peripheral Arterial Disease
A Trial to Evaluate the Safety and Efficacy of the Passeo-18 Lux Drug-coated Balloon of Biotronik in the Treatment of the Femoropopliteal Artery Compared to the Medtronic IN.PACT Admiral Drug-coated Balloon.
The BIOPACT RCT tiral investigates the efficacy and safety of stenosis, restenosis or occlusions in the femoropopliteal artery of patients presenting a rutherford classification 2,3 or 4 with a Passeo-18 Lux drug-coated balloon…
- Trial name
- BIOPACT-RCT (NCT03884257)
- Testing
- Passeo-18 Lux treatment group, IN.PACT Admiral treatment group
- Where
- 14 sites in Austria, Belgium and 2 more
- Volunteers
- 302 people
- Sponsor
- KANDO Research