Clinical trials: Arteriosclerosis
Coronary Artery Disease
SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries
The SYNTAX trial is designed to determine the best treatment for patients with complex coronary disease (blocked or narrowed arteries in both the right and left sides of the heart) by randomizing patients to receive either…
- Trial name
- SYNTAX (NCT00114972)
- Testing
- Polymer-based Paclitaxel-Eluting TAXUS Express2-SR Stent, Coronary Artery Bypass Surgery
- Where
- 106 sites in United States, Austria and 16 more
- Volunteers
- 1,800 people
- Sponsor
- Boston Scientific Corporation
Cardiovascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery and Cardiovascular Events
Pathological and clinical studies have consistently demonstrated that abnormalities in thrombosis and hemostasis play a major role in the pathogenesis of atherosclerosis and atherothrombosis.
- Conditions
- Cardiovascular Disease, Peripheral Artery Disease, Critical Limb Ischemia
- Trial name
- PACE (NCT02106429)
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- NYU Langone Health
Amputation, Diabetes Mellitus, Type 2
Physical Activity Behavior Change for Older Adults After Dysvascular Amputation
This pilot study will use mobile-health technology to deliver an intervention designed for lasting physical activity behavior change.
- Conditions
- Amputation, Diabetes Mellitus, Type 2, Peripheral Artery Disease
- Trial name
- PABC (NCT02738086)
- Testing
- Physical Activity Behavior Change (PABC)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Peripheral Arterial Disease
Lutonix or Inpact for tHE tReatment Of fEmeropopliteal Stenosis - Drug Coated Balloon
Investigators hypothesize in patients presenting with significant peripheral arterial disease with clinical indications for treatment with angioplasty, there will be a difference in 12 month patency between the subjects with…
- Trial name
- HEROES-DCB (NCT02812966)
- Testing
- Lutonix, IN.PACT
- Where
- 6 sites in United States
- Volunteers
- 35 people
- Sponsor
- Wake Forest University Health Sciences
Vascular System Injuries, Lipid Metabolism Disorders
Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years
Women have a natural protection that gives them greater longevity. One hypothesis most commonly used is the estrogen protection in the premenopausal period.
- Conditions
- Vascular System Injuries, Lipid Metabolism Disorders, Endothelial Disfunction
- Trial name
- NCT01668836
- Testing
- Resveratrol, Caloric restriction
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Coronary Arteriosclerosis
Radial Artery Versus Saphenous Vein Patency (RSVP) Study
The purpose of this study is to determine whether the radial artery (artery in the arm) or saphenous vein (vein in the leg), when used as bypass grafts for coronary artery bypass surgery, have a greater patency rate (degree of…
- Trial name
- RSVP (NCT00139399)
- Testing
- Coronary artery bypass graft (CABG) surgery
- Where
- United Kingdom
- Volunteers
- 142 people
- Sponsor
- Imperial College London
Ischemic Heart Disease, Angina Pectoris
XIENCE PRIME SV Everolimus Eluting Coronary Stent Japan Post Marketing Surveillance (XIENCE PRIME SV Japan PMS)
The objective of the study is to evaluate the safety and efficacy of XIENCE PRIME SV in real world practice in Japanese hospitals.
- Conditions
- Ischemic Heart Disease, Angina Pectoris, Coronary Artery Disease, Coronary Artery Occlusion
- Trial name
- NCT02513719
- Testing
- XIENCE PRIME SV Everolimus Eluting Coronary Stent
- Where
- 33 sites in Japan
- Volunteers
- 312 people
- Sponsor
- Abbott Medical Devices
Peripheral Artery Disease
Improving Walking in Peripheral Artery Disease
Peripheral artery disease (PAD) is a cardiovascular disease manifesting from systemic atherosclerosis that blocks the leg arteries and results in insufficient blood flow to the lower extremities.
- Trial name
- PAD (NCT05103280)
- Testing
- Assistive tennis shoes
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease
Trial to Assess Chelation Therapy (TACT)
The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease.
- Trial name
- NCT00044213
- Testing
- EDTA, High Dose Vitamin
- Where
- 86 sites in United States, Canada
- Volunteers
- 1,708 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Acute Coronary Syndrome
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death…
- Trial name
- AEGIS-II (NCT03473223)
- Testing
- Apolipoprotein A-I [human] (apoA-I)
- Where
- 903 sites in United States, Argentina and 47 more
- Volunteers
- 18,226 people
- Sponsor
- CSL Behring
Coronary Artery Disease, Atherosclerosis
SPIRIT Small Vessel Registry
To evaluate the safety and effectiveness of the 2.25 mm XIENCE V® Everolimus Eluting Coronary Stent System (XIENCE V® EECSS) in improving coronary luminal diameter in subjects with ischemic heart disease due to a maximum of two…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Myocardial Ischemia
- Trial name
- SPIRIT SV (NCT00783796)
- Testing
- 2.25 mm XIENCE V® Everolimus Eluting Coronary Stent System
- Where
- 34 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
Remote Ischemic Preconditioning in ad Hoc Percutaneous Coronary Interventions
Elective percutaneous coronary intervention (PCI) is associated with troponin release in approximately one third of cases. Myocardial necrosis may result from downstream embolization of atheromatous material, coronary side-branch…
- Trial name
- NCT01158716
- Testing
- Remote Ischemic Preconditioning
- Where
- Greece
- Volunteers
- 94 people
- Sponsor
- Cardiovascular Research Society, Greece
Coronary Artery Disease, Coronary Atherosclerosis
Study Comparing the CYPHER® ELITE™ to the CYPHER® Bx VELOCITY® Sirolimus-Eluting Stent Systems
The objective of this study is to show similar (non-inferior) safety and effectiveness between CYPHER® ELITE™ and CYPHER® Bx VELOCITY® Sirolimus-Eluting Stent Systems in a prospective, multi-center, randomized clinical study for…
- Trial name
- ELITE (NCT00715884)
- Testing
- CYPHER® ELITE™ Sirolimus-Eluting Stent System, CYPHER® Bx VELOCITY® Sirolimus-eluting Stent System
- Where
- United States
- Volunteers
- 678 people
- Sponsor
- Cordis US Corp.
Depression, Depressive Symptoms
Beating the Blues for Your Heart
The objective of this clinical trial is to evaluate whether a computerized depression treatment, delivered before the onset of heart disease, reduces the risk of heart disease in the future.
- Conditions
- Depression, Depressive Symptoms, Cardiovascular Disease (CVD), Coronary Artery Disease (CAD)
- Trial name
- BtB-Heart (NCT01605552)
- Testing
- Beating the Blues (BtB), Usual Care
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Coronary Artery Disease
Perfusion Imaging and CT -Understanding Relative Efficacy
To determine the relative efficacy of Cardiac Computed Tomography Angiography (CCTA) and Single Positron Emission Computed Tomography (SPECT) in patients with an intermediate risk of CAD.
- Trial name
- PICTURE (NCT00486447)
- Testing
- 64 Channel VCT
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- GE Healthcare
Peripheral Artery Disease
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Pentoxifylline Versus Cilostazol
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- NCT05635370
- Testing
- Pentoxifylline, Cilostazol
- Where
- United States
- Volunteers
- 10,398 people
- Sponsor
- Brigham and Women's Hospital
Peripheral Arterial Disease
Momentum-enabled Treadling Methodology to Improve Gait and Enhance Mobility
This is a pilot study of a new exercise device (TREDLR) designed to facilitate repetitive ankle flexion/extension movements (i.e., "treadling") through a momentum-driven internal flywheel while seated.
- Trial name
- NCT03891641
- Testing
- Treadwell Tredlr
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Critical Limb Ischemia
Use of Clearway™ Balloon vs. Mechanical Thrombectomy as Initial Treatment for Acute Limb Ischemia
The purpose of this study is to compare the effects (positive and negative) of two different devices available to treat people with critical limb ischemia, which involves a sudden decrease in blood flow to the leg that causes a…
- Trial name
- NCT00869375
- Testing
- Endovascular peripheral intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Oklahoma
Coronary Artery Disease
Assessment of Coronary Artery Disease by Hybrid PET/CT
There have been many advances in the test used to look for heart disease. An example of this newer technology is the Multislice CT scan (MSCT) and Positron Emission Tomography (PET) scans.
- Trial name
- NCT00320931
- Testing
- Hybrid PET/CT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Atherosclerosis, Cardiovascular Diseases
Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions
This study will compare medical therapy plus stenting of hemodynamically significant renal artery stenoses versus medical therapy alone in patients with systolic hypertension and renal artery stenosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Hypertension, Renovascular, Renal Artery Obstruction
- Trial name
- CORAL (NCT00081731)
- Testing
- Atacand/HCT, Caduet, GENESISTM Embolic Protection Stent and Angioguard Device (Angioplasty plus stenting)
- Where
- United States
- Volunteers
- 947 people
- Sponsor
- Baim Institute for Clinical Research